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- Publisher Website: 10.1038/nri1552
- Scopus: eid_2-s2.0-13444283466
- PMID: 15688040
- WOS: WOS:000226720800013
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Article: Roles of interferon-regulatory factors in T-helper-cell differentiation
Title | Roles of interferon-regulatory factors in T-helper-cell differentiation |
---|---|
Authors | |
Issue Date | 2005 |
Citation | Nature Reviews Immunology, 2005, v. 5, n. 2, p. 125-135 How to Cite? |
Abstract | Members of the interferon-regulatory factor family of transcription factors have long been known to be intracellular mediators of the effects of interferons. In recent years, interferon-regulatory factors have also been shown to have an essential role in the differentiation of T helper cells, both by modulating the functions of antigen-presenting cells and by having direct effects on the T helper cells themselves. Depending on the interferon-regulatory factor involved, the differentiation of T helper cells to either T helper 1 cells or T helper 2 cells can be influenced. In this article, we provide an overview of this relatively new and still underappreciated role of interferon-regulatory factors. |
Persistent Identifier | http://hdl.handle.net/10722/291686 |
ISSN | 2023 Impact Factor: 67.7 2023 SCImago Journal Rankings: 16.009 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lohoff, Michael | - |
dc.contributor.author | Mak, Tak W. | - |
dc.date.accessioned | 2020-11-17T14:54:54Z | - |
dc.date.available | 2020-11-17T14:54:54Z | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | Nature Reviews Immunology, 2005, v. 5, n. 2, p. 125-135 | - |
dc.identifier.issn | 1474-1733 | - |
dc.identifier.uri | http://hdl.handle.net/10722/291686 | - |
dc.description.abstract | Members of the interferon-regulatory factor family of transcription factors have long been known to be intracellular mediators of the effects of interferons. In recent years, interferon-regulatory factors have also been shown to have an essential role in the differentiation of T helper cells, both by modulating the functions of antigen-presenting cells and by having direct effects on the T helper cells themselves. Depending on the interferon-regulatory factor involved, the differentiation of T helper cells to either T helper 1 cells or T helper 2 cells can be influenced. In this article, we provide an overview of this relatively new and still underappreciated role of interferon-regulatory factors. | - |
dc.language | eng | - |
dc.relation.ispartof | Nature Reviews Immunology | - |
dc.title | Roles of interferon-regulatory factors in T-helper-cell differentiation | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1038/nri1552 | - |
dc.identifier.pmid | 15688040 | - |
dc.identifier.scopus | eid_2-s2.0-13444283466 | - |
dc.identifier.volume | 5 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 125 | - |
dc.identifier.epage | 135 | - |
dc.identifier.isi | WOS:000226720800013 | - |
dc.identifier.issnl | 1474-1733 | - |