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Article: Impaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30-Deficient Mice

TitleImpaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30-Deficient Mice
Authors
Issue Date1996
Citation
Cell, 1996, v. 84, n. 4, p. 551-562 How to Cite?
AbstractCD30 is found on Reed-Stern berg cells of Hodgkin's disease and on a variety of non-Hodgkin's lymphoma cells and is up-regulated on cells after Epstein-Barr virus, human T cell leukemia virus, and HIV infections. We report here that the thymus in CD30-deficient mice contains elevated numbers of thymocytes. Activation-induced death of thymocytes after CD3 cross-linking is impaired both in vitro and in vivo. Breeding the CD30 mutation separately into αβTCR- or γδTCR-transgenic mice revealed a gross defect in negative but not positive selection. Thus, like TNF-receptors and Fas/Apo-1, the CD30 receptor is involved in cell death signaling. It is also an important coreceptor that participates in thymic deletion.
Persistent Identifierhttp://hdl.handle.net/10722/291685
ISSN
2023 Impact Factor: 45.5
2023 SCImago Journal Rankings: 24.342
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorAmakawa, Ryuichi-
dc.contributor.authorHakem, Anne-
dc.contributor.authorKundig, Thomas M.-
dc.contributor.authorMatsuyama, Toshifumi-
dc.contributor.authorSimard, John J.L.-
dc.contributor.authorTimms, Emma-
dc.contributor.authorWakeham, Andrew-
dc.contributor.authorMittruecker, Hans Willi-
dc.contributor.authorGriesser, Henrik-
dc.contributor.authorTakimoto, Hiroaki-
dc.contributor.authorSchmits, Rudolf-
dc.contributor.authorShahinian, Arda-
dc.contributor.authorOhashi, Pamela S.-
dc.contributor.authorPenninger, Josef M.-
dc.contributor.authorMak, Tak W.-
dc.date.accessioned2020-11-17T14:54:54Z-
dc.date.available2020-11-17T14:54:54Z-
dc.date.issued1996-
dc.identifier.citationCell, 1996, v. 84, n. 4, p. 551-562-
dc.identifier.issn0092-8674-
dc.identifier.urihttp://hdl.handle.net/10722/291685-
dc.description.abstractCD30 is found on Reed-Stern berg cells of Hodgkin's disease and on a variety of non-Hodgkin's lymphoma cells and is up-regulated on cells after Epstein-Barr virus, human T cell leukemia virus, and HIV infections. We report here that the thymus in CD30-deficient mice contains elevated numbers of thymocytes. Activation-induced death of thymocytes after CD3 cross-linking is impaired both in vitro and in vivo. Breeding the CD30 mutation separately into αβTCR- or γδTCR-transgenic mice revealed a gross defect in negative but not positive selection. Thus, like TNF-receptors and Fas/Apo-1, the CD30 receptor is involved in cell death signaling. It is also an important coreceptor that participates in thymic deletion.-
dc.languageeng-
dc.relation.ispartofCell-
dc.titleImpaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30-Deficient Mice-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/S0092-8674(00)81031-4-
dc.identifier.pmid8598042-
dc.identifier.scopuseid_2-s2.0-13244300652-
dc.identifier.volume84-
dc.identifier.issue4-
dc.identifier.spage551-
dc.identifier.epage562-
dc.identifier.isiWOS:A1996TX17600008-
dc.identifier.issnl0092-8674-

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