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- Publisher Website: 10.1016/S1044-5323(03)00034-4
- Scopus: eid_2-s2.0-0742287249
- PMID: 14563116
- WOS: WOS:000184400600007
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Article: From antigen to activation: Specific signal transduction pathways linking antigen receptors to NF-κB
Title | From antigen to activation: Specific signal transduction pathways linking antigen receptors to NF-κB |
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Authors | |
Keywords | Lymphocyte Antigen receptor NF-κB Signal transduction BCL10 |
Issue Date | 2003 |
Citation | Seminars in Immunology, 2003, v. 15, n. 3, p. 177-183 How to Cite? |
Abstract | A precise balance between cellular apoptosis and cellular survival is essential for the proper functioning of the immune system. Whereas apoptosis eliminates self-reactive or supernumerary lymphocytes, survival signaling that counteracts apoptotic programs is needed to allow B and T lymphocytes that recognize pathogens to become activated and expand in response to infection. A major regulator of lymphocyte survival and activation is the transcription factor NF-κB. Controlled activation of NF-κB is essential for normal innate and adaptive immune responses, and dysregulated NF-κB signaling in lymphocytes contributes to diseases ranging from chronic inflammation and autoimmunity to lymphoma. The core NF-κB activating machinery composed of the NF-κB, IκB and IKK proteins is relatively well-characterized, but it is less clear how distinct upstream stimuli activate NF-κB in a tissue-, time- and signal-specific manner. In this review, we discuss recent insights into the specific signal transduction pathways leading to NF-κB activation that are triggered by engagement of the antigen receptors of T and B cells. We focus mainly on T cell receptor (TCR)-mediated NF-κB activation and draw parallels to B cell receptor (BCR)-mediated NF-κB activation where appropriate. © 2003 Published by Elsevier Science Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/291674 |
ISSN | 2021 Impact Factor: 10.671 2020 SCImago Journal Rankings: 3.765 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ruland, Jürgen | - |
dc.contributor.author | Mak, Tak W. | - |
dc.date.accessioned | 2020-11-17T14:54:52Z | - |
dc.date.available | 2020-11-17T14:54:52Z | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | Seminars in Immunology, 2003, v. 15, n. 3, p. 177-183 | - |
dc.identifier.issn | 1044-5323 | - |
dc.identifier.uri | http://hdl.handle.net/10722/291674 | - |
dc.description.abstract | A precise balance between cellular apoptosis and cellular survival is essential for the proper functioning of the immune system. Whereas apoptosis eliminates self-reactive or supernumerary lymphocytes, survival signaling that counteracts apoptotic programs is needed to allow B and T lymphocytes that recognize pathogens to become activated and expand in response to infection. A major regulator of lymphocyte survival and activation is the transcription factor NF-κB. Controlled activation of NF-κB is essential for normal innate and adaptive immune responses, and dysregulated NF-κB signaling in lymphocytes contributes to diseases ranging from chronic inflammation and autoimmunity to lymphoma. The core NF-κB activating machinery composed of the NF-κB, IκB and IKK proteins is relatively well-characterized, but it is less clear how distinct upstream stimuli activate NF-κB in a tissue-, time- and signal-specific manner. In this review, we discuss recent insights into the specific signal transduction pathways leading to NF-κB activation that are triggered by engagement of the antigen receptors of T and B cells. We focus mainly on T cell receptor (TCR)-mediated NF-κB activation and draw parallels to B cell receptor (BCR)-mediated NF-κB activation where appropriate. © 2003 Published by Elsevier Science Ltd. | - |
dc.language | eng | - |
dc.relation.ispartof | Seminars in Immunology | - |
dc.subject | Lymphocyte | - |
dc.subject | Antigen receptor | - |
dc.subject | NF-κB | - |
dc.subject | Signal transduction | - |
dc.subject | BCL10 | - |
dc.title | From antigen to activation: Specific signal transduction pathways linking antigen receptors to NF-κB | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/S1044-5323(03)00034-4 | - |
dc.identifier.pmid | 14563116 | - |
dc.identifier.scopus | eid_2-s2.0-0742287249 | - |
dc.identifier.volume | 15 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 177 | - |
dc.identifier.epage | 183 | - |
dc.identifier.isi | WOS:000184400600007 | - |
dc.identifier.issnl | 1044-5323 | - |