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Article: Absence of the CD44 gene prevents sarcoma metastasis

TitleAbsence of the CD44 gene prevents sarcoma metastasis
Authors
Issue Date2002
Citation
Cancer Research, 2002, v. 62, n. 8, p. 2281-2286 How to Cite?
AbstractTo test the role of the CD44 gene in tumorigenesis, mice with the min mutation of the APC gene or with the tm1 mutation of the p53 gene were crossed with CD44 knockout mice. The absence of CD44 gene products did not affect tumor incidence or survival; however, mice with disruption of the CD44 gene showed virtually aborted metastasis formation of osteosarcomas. This is in agreement with the role attributed to CD44 variants in the spread of cancer. Therefore, CD44 gene products are not essential for tumor incidence and growth but are important in regulating metastasis formation.
Persistent Identifierhttp://hdl.handle.net/10722/291614
ISSN
2023 Impact Factor: 12.5
2023 SCImago Journal Rankings: 3.468
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWeber, Georg F.-
dc.contributor.authorBronson, Roderick T.-
dc.contributor.authorIlagan, John-
dc.contributor.authorCantor, Harvey-
dc.contributor.authorSchmits, Rudolf-
dc.contributor.authorMak, Tak W.-
dc.date.accessioned2020-11-17T14:54:45Z-
dc.date.available2020-11-17T14:54:45Z-
dc.date.issued2002-
dc.identifier.citationCancer Research, 2002, v. 62, n. 8, p. 2281-2286-
dc.identifier.issn0008-5472-
dc.identifier.urihttp://hdl.handle.net/10722/291614-
dc.description.abstractTo test the role of the CD44 gene in tumorigenesis, mice with the min mutation of the APC gene or with the tm1 mutation of the p53 gene were crossed with CD44 knockout mice. The absence of CD44 gene products did not affect tumor incidence or survival; however, mice with disruption of the CD44 gene showed virtually aborted metastasis formation of osteosarcomas. This is in agreement with the role attributed to CD44 variants in the spread of cancer. Therefore, CD44 gene products are not essential for tumor incidence and growth but are important in regulating metastasis formation.-
dc.languageeng-
dc.relation.ispartofCancer Research-
dc.titleAbsence of the CD44 gene prevents sarcoma metastasis-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid11956084-
dc.identifier.scopuseid_2-s2.0-0037089521-
dc.identifier.volume62-
dc.identifier.issue8-
dc.identifier.spage2281-
dc.identifier.epage2286-
dc.identifier.isiWOS:000175105700016-
dc.identifier.issnl0008-5472-

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