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Article: Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4

TitleDysregulated T helper cell differentiation in the absence of interferon regulatory factor 4
Authors
Issue Date2002
Citation
Proceedings of the National Academy of Sciences of the United States of America, 2002, v. 99, n. 18, p. 11808-11812 How to Cite?
AbstractCertain IFN regulatory factor (IRF) transcription factors indirectly influence T helper (Th) cell differentiation by regulating the production of IL-12. Here, we show that IRF4 directly regulates Th cell differentiation in vitro and in vivo during murine leishmaniasis. In the absence of IRF4, IL-12-induced Th1 cell differentiation was compromised, while IL-4 failed to induce Th2 cell differentiation. Instead, IL-4 tended to induce Th1 cells, defined by production of IFN-γ and TNF. Although early IL-4 signaling was normal in IRF4-/- Th cells, the protein GATA-3, a transcription factor critical for Th2 development, was not up-regulated following IL-4 treatment. Retroviral overexpression of GATA-3 rescued Th2 differentiation. Therefore, IRF4 deficiency manifests itself as severely dysregulated Th cell differentiation.
Persistent Identifierhttp://hdl.handle.net/10722/291610
ISSN
2023 Impact Factor: 9.4
2023 SCImago Journal Rankings: 3.737
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLohoff, Michael-
dc.contributor.authorMittrücker, Hans Willi-
dc.contributor.authorPrechtl, Stefan-
dc.contributor.authorBischof, Susi-
dc.contributor.authorSommer, Frank-
dc.contributor.authorKock, Sonja-
dc.contributor.authorFerrick, David A.-
dc.contributor.authorDuncan, Gordon S.-
dc.contributor.authorGessner, Andre-
dc.contributor.authorMak, Tak W.-
dc.date.accessioned2020-11-17T14:54:44Z-
dc.date.available2020-11-17T14:54:44Z-
dc.date.issued2002-
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America, 2002, v. 99, n. 18, p. 11808-11812-
dc.identifier.issn0027-8424-
dc.identifier.urihttp://hdl.handle.net/10722/291610-
dc.description.abstractCertain IFN regulatory factor (IRF) transcription factors indirectly influence T helper (Th) cell differentiation by regulating the production of IL-12. Here, we show that IRF4 directly regulates Th cell differentiation in vitro and in vivo during murine leishmaniasis. In the absence of IRF4, IL-12-induced Th1 cell differentiation was compromised, while IL-4 failed to induce Th2 cell differentiation. Instead, IL-4 tended to induce Th1 cells, defined by production of IFN-γ and TNF. Although early IL-4 signaling was normal in IRF4-/- Th cells, the protein GATA-3, a transcription factor critical for Th2 development, was not up-regulated following IL-4 treatment. Retroviral overexpression of GATA-3 rescued Th2 differentiation. Therefore, IRF4 deficiency manifests itself as severely dysregulated Th cell differentiation.-
dc.languageeng-
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of America-
dc.titleDysregulated T helper cell differentiation in the absence of interferon regulatory factor 4-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1073/pnas.182425099-
dc.identifier.pmid12189207-
dc.identifier.pmcidPMC129350-
dc.identifier.scopuseid_2-s2.0-0037015052-
dc.identifier.volume99-
dc.identifier.issue18-
dc.identifier.spage11808-
dc.identifier.epage11812-
dc.identifier.isiWOS:000177843100050-
dc.identifier.issnl0027-8424-

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