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Article: PTEN function in mammalian cell size regulation

TitlePTEN function in mammalian cell size regulation
Authors
Backman, Stéphanie A.Stambolic, VukMak, Tak W.
Issue Date2002
Citation
Current Opinion in Neurobiology, 2002, v. 12, n. 5, p. 516-522 How to Cite?
DOI: http://dx.doi.org/10.1016/S0959-4388(02)00354-9
AbstractThe PTEN tumor suppressor gene is a lipid phosphatase that negatively regulates cell survival mediated by the phosphatidyl inositol 3′ kinase-protein kinase B/Akt signaling pathway. Recent in vivo studies have revealed a novel role for PTEN in the size control of neurons. Dysregulation of cell growth control by PTEN is associated with the neurological disorder Lhermitte-Duclos disease. PTEN may regulate cell size through effects on protein translation.
Persistent Identifierhttp://hdl.handle.net/10722/291601
ISSN
0959-4388
2023 Impact Factor: 4.8
2023 SCImago Journal Rankings: 2.982
ISI Accession Number ID
WOS:000178693000007

 

DC FieldValueLanguage
dc.contributor.authorBackman, Stéphanie A.-
dc.contributor.authorStambolic, Vuk-
dc.contributor.authorMak, Tak W.-
dc.date.accessioned2020-11-17T14:54:43Z-
dc.date.available2020-11-17T14:54:43Z-
dc.date.issued2002-
dc.identifier.citationCurrent Opinion in Neurobiology, 2002, v. 12, n. 5, p. 516-522-
dc.identifier.issn0959-4388-
dc.identifier.urihttp://hdl.handle.net/10722/291601-
dc.description.abstractThe PTEN tumor suppressor gene is a lipid phosphatase that negatively regulates cell survival mediated by the phosphatidyl inositol 3′ kinase-protein kinase B/Akt signaling pathway. Recent in vivo studies have revealed a novel role for PTEN in the size control of neurons. Dysregulation of cell growth control by PTEN is associated with the neurological disorder Lhermitte-Duclos disease. PTEN may regulate cell size through effects on protein translation.-
dc.languageeng-
dc.relation.ispartofCurrent Opinion in Neurobiology-
dc.titlePTEN function in mammalian cell size regulation-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0959-4388(02)00354-9-
dc.identifier.pmid12367630-
dc.identifier.scopuseid_2-s2.0-0036801311-
dc.identifier.volume12-
dc.identifier.issue5-
dc.identifier.spage516-
dc.identifier.epage522-
dc.identifier.isiWOS:000178693000007-
dc.identifier.issnl0959-4388-

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