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- Publisher Website: 10.1093/emboj/20.20.5678
- Scopus: eid_2-s2.0-0035887040
- PMID: 11598011
- WOS: WOS:000171766300014
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Article: TRAF6 is a critical mediator of signal transduction by the viral oncogene latent membrane protein 1
Title | TRAF6 is a critical mediator of signal transduction by the viral oncogene latent membrane protein 1 |
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Authors | |
Keywords | LMP1 p38 MAPK TRADD Signal transduction TRAF6 |
Issue Date | 2001 |
Citation | EMBO Journal, 2001, v. 20, n. 20, p. 5678-5691 How to Cite? |
Abstract | The oncogenic latent membrane protein 1 (LMP1) of the Epstein-Barr virus recruits tumor necrosis factor-receptor (TNFR)-associated factors (TRAFs), the TNFR-associated death domain protein (TRADD) and JAK3 to induce intracellular signaling pathways. LMP1 serves as the prototype of a TRADD-binding receptor that transforms cells but does not induce apoptosis. Here we show that TRAF6 critically mediates LMP1 signaling to p38 mitogen-activated protein kinase (MAPK) via a MAPK kinase 6-dependent pathway. In addition, NF-κB but not c-Jun N-terminal kinase 1 (JNK1) induction by LMP1 involves TRAF6. The PxQxT motif of the LMP1 C-terminal activator region 1 (CTAR1) and tyrosine 384 of CTAR2 together are essential for full p38 MAPK activation and for TRAF6 recruitment to the LMP1 signaling complex. Dominant-negative TRADD blocks p38 MAPK activation by LMP1. The data suggest that entry of TRAF6 into the LMP1 complex is mediated by TRADD and TRAF2. In TRAF6-knockout fibroblasts, significant induction of p38 MAPK by LMP1 is dependent on the ectopic expression of TRAF6. We describe a novel role of TRAF6 as an essential signaling mediator of a transforming oncogene, downstream of TRADD and TRAF2. |
Persistent Identifier | http://hdl.handle.net/10722/291587 |
ISSN | 2023 Impact Factor: 9.4 2023 SCImago Journal Rankings: 5.489 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Schultheiss, Ute | - |
dc.contributor.author | Püschner, Stephanie | - |
dc.contributor.author | Kremmer, Elisabeth | - |
dc.contributor.author | Mak, Tak W. | - |
dc.contributor.author | Engelmann, Hartmut | - |
dc.contributor.author | Hammerschmidt, Wolfgang | - |
dc.contributor.author | Kieser, Arnd | - |
dc.date.accessioned | 2020-11-17T14:54:41Z | - |
dc.date.available | 2020-11-17T14:54:41Z | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | EMBO Journal, 2001, v. 20, n. 20, p. 5678-5691 | - |
dc.identifier.issn | 0261-4189 | - |
dc.identifier.uri | http://hdl.handle.net/10722/291587 | - |
dc.description.abstract | The oncogenic latent membrane protein 1 (LMP1) of the Epstein-Barr virus recruits tumor necrosis factor-receptor (TNFR)-associated factors (TRAFs), the TNFR-associated death domain protein (TRADD) and JAK3 to induce intracellular signaling pathways. LMP1 serves as the prototype of a TRADD-binding receptor that transforms cells but does not induce apoptosis. Here we show that TRAF6 critically mediates LMP1 signaling to p38 mitogen-activated protein kinase (MAPK) via a MAPK kinase 6-dependent pathway. In addition, NF-κB but not c-Jun N-terminal kinase 1 (JNK1) induction by LMP1 involves TRAF6. The PxQxT motif of the LMP1 C-terminal activator region 1 (CTAR1) and tyrosine 384 of CTAR2 together are essential for full p38 MAPK activation and for TRAF6 recruitment to the LMP1 signaling complex. Dominant-negative TRADD blocks p38 MAPK activation by LMP1. The data suggest that entry of TRAF6 into the LMP1 complex is mediated by TRADD and TRAF2. In TRAF6-knockout fibroblasts, significant induction of p38 MAPK by LMP1 is dependent on the ectopic expression of TRAF6. We describe a novel role of TRAF6 as an essential signaling mediator of a transforming oncogene, downstream of TRADD and TRAF2. | - |
dc.language | eng | - |
dc.relation.ispartof | EMBO Journal | - |
dc.subject | LMP1 | - |
dc.subject | p38 MAPK | - |
dc.subject | TRADD | - |
dc.subject | Signal transduction | - |
dc.subject | TRAF6 | - |
dc.title | TRAF6 is a critical mediator of signal transduction by the viral oncogene latent membrane protein 1 | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1093/emboj/20.20.5678 | - |
dc.identifier.pmid | 11598011 | - |
dc.identifier.pmcid | PMC125680 | - |
dc.identifier.scopus | eid_2-s2.0-0035887040 | - |
dc.identifier.volume | 20 | - |
dc.identifier.issue | 20 | - |
dc.identifier.spage | 5678 | - |
dc.identifier.epage | 5691 | - |
dc.identifier.isi | WOS:000171766300014 | - |
dc.identifier.issnl | 0261-4189 | - |