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- Publisher Website: 10.1038/35095551
- Scopus: eid_2-s2.0-0035495829
- PMID: 11905810
- WOS: WOS:000180397900019
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Article: Knockout mice: A paradigm shift in modern immunology
Title | Knockout mice: A paradigm shift in modern immunology |
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Authors | |
Issue Date | 2001 |
Citation | Nature Reviews Immunology, 2001, v. 1, n. 1, p. 11-19 How to Cite? |
Abstract | In the past decade, advances in genetic engineering and mouse knockout technology have transformed our understanding of the immune system. In particular, new perspectives on T-cell development, co-stimulation and activation have emerged from the study of single and multiple gene-knockout animals, as well as from conditional knockout and 'knock-in' mutants. Analysis of these animals has clarified important intracellular signalling pathways and has shed light on the regulatory mechanisms that govern normal immune responses and autoimmunity. |
Persistent Identifier | http://hdl.handle.net/10722/291570 |
ISSN | 2023 Impact Factor: 67.7 2023 SCImago Journal Rankings: 16.009 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Mak, Tak W. | - |
dc.contributor.author | Penninger, Josef M. | - |
dc.contributor.author | Ohashi, Pamela S. | - |
dc.date.accessioned | 2020-11-17T14:54:39Z | - |
dc.date.available | 2020-11-17T14:54:39Z | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | Nature Reviews Immunology, 2001, v. 1, n. 1, p. 11-19 | - |
dc.identifier.issn | 1474-1733 | - |
dc.identifier.uri | http://hdl.handle.net/10722/291570 | - |
dc.description.abstract | In the past decade, advances in genetic engineering and mouse knockout technology have transformed our understanding of the immune system. In particular, new perspectives on T-cell development, co-stimulation and activation have emerged from the study of single and multiple gene-knockout animals, as well as from conditional knockout and 'knock-in' mutants. Analysis of these animals has clarified important intracellular signalling pathways and has shed light on the regulatory mechanisms that govern normal immune responses and autoimmunity. | - |
dc.language | eng | - |
dc.relation.ispartof | Nature Reviews Immunology | - |
dc.title | Knockout mice: A paradigm shift in modern immunology | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1038/35095551 | - |
dc.identifier.pmid | 11905810 | - |
dc.identifier.scopus | eid_2-s2.0-0035495829 | - |
dc.identifier.volume | 1 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 11 | - |
dc.identifier.epage | 19 | - |
dc.identifier.isi | WOS:000180397900019 | - |
dc.identifier.issnl | 1474-1733 | - |