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Article: Interleukin 13 and interleukin 13 receptor are frequently expressed by Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma

TitleInterleukin 13 and interleukin 13 receptor are frequently expressed by Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma
Authors
Issue Date2001
Citation
Blood, 2001, v. 97, n. 1, p. 250-255 How to Cite?
AbstractHodgkin lymphoma (HL) is characterized by the abnormal expression of multiple cytokines, accounting for its unique clinicopathologic features. We have previously shown that interleukin-13 (IL-13) is secreted by HL cell lines and may serve as an autocrine growth factor. To determine the frequency of IL-13 expression in lymphoma patients, tissue sections from 36 patients with classical HL, 5 patients with nodular lymphocyte predominance HL (NLPHL), and 23 patients with non-Hodgkin lymphoma (NHL) were subjected to in situ hybridization. In 31 of 36 cases (86%) of classical HL patients of all histologic subtypes, between 25% to almost 100% of Hodgkin and Reed Sternberg (HRS) cells were positive for IL-13 expression. In contrast, in no case of NLPHL and in only 4 of 23 NHL cases (1 of 5 T-cell-rich B-cell lymphomas, 2 of 5 anaplastic large cell lymphomas, and 1 of 5 peripheral T-cell lymphomas) did the neoplastic cells express IL-13. The expression of the IL-13 receptor chain α1 (IL-13Rα1) was also analyzed by in situ hybridization. In 24 of 27 (89%) cases of classical HL, between 25% to 75% of HRS cells, as well as a high frequency of lymphocytes and histiocytes, were positive for IL-13Rα1 expression. These results were confirmed by the construction of complementary DNA libraries from single HRS cells, followed by polymerase chain reaction analysis, in which IL-13Rα1 transcripts were found to be present in all 6 cases of HL. These data indicate that expression of IL-13 and IL-13Rα1 is a common feature of HRS cells in HL, consistent with the hypothesis that IL-13 may play a role in autocrine growth in classical HL. © 2001 by The American Society of Hematology.
Persistent Identifierhttp://hdl.handle.net/10722/291564
ISSN
2023 Impact Factor: 21.0
2023 SCImago Journal Rankings: 5.272
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSkinnider, Brian F.-
dc.contributor.authorElia, Andrew J.-
dc.contributor.authorGascoyne, Randy D.-
dc.contributor.authorTrümper, Lorenz H.-
dc.contributor.authorVon Bonin, Frederike-
dc.contributor.authorKapp, Ursula-
dc.contributor.authorPatterson, Bruce-
dc.contributor.authorSnow, Bryan E.-
dc.contributor.authorMak, Tak W.-
dc.date.accessioned2020-11-17T14:54:38Z-
dc.date.available2020-11-17T14:54:38Z-
dc.date.issued2001-
dc.identifier.citationBlood, 2001, v. 97, n. 1, p. 250-255-
dc.identifier.issn0006-4971-
dc.identifier.urihttp://hdl.handle.net/10722/291564-
dc.description.abstractHodgkin lymphoma (HL) is characterized by the abnormal expression of multiple cytokines, accounting for its unique clinicopathologic features. We have previously shown that interleukin-13 (IL-13) is secreted by HL cell lines and may serve as an autocrine growth factor. To determine the frequency of IL-13 expression in lymphoma patients, tissue sections from 36 patients with classical HL, 5 patients with nodular lymphocyte predominance HL (NLPHL), and 23 patients with non-Hodgkin lymphoma (NHL) were subjected to in situ hybridization. In 31 of 36 cases (86%) of classical HL patients of all histologic subtypes, between 25% to almost 100% of Hodgkin and Reed Sternberg (HRS) cells were positive for IL-13 expression. In contrast, in no case of NLPHL and in only 4 of 23 NHL cases (1 of 5 T-cell-rich B-cell lymphomas, 2 of 5 anaplastic large cell lymphomas, and 1 of 5 peripheral T-cell lymphomas) did the neoplastic cells express IL-13. The expression of the IL-13 receptor chain α1 (IL-13Rα1) was also analyzed by in situ hybridization. In 24 of 27 (89%) cases of classical HL, between 25% to 75% of HRS cells, as well as a high frequency of lymphocytes and histiocytes, were positive for IL-13Rα1 expression. These results were confirmed by the construction of complementary DNA libraries from single HRS cells, followed by polymerase chain reaction analysis, in which IL-13Rα1 transcripts were found to be present in all 6 cases of HL. These data indicate that expression of IL-13 and IL-13Rα1 is a common feature of HRS cells in HL, consistent with the hypothesis that IL-13 may play a role in autocrine growth in classical HL. © 2001 by The American Society of Hematology.-
dc.languageeng-
dc.relation.ispartofBlood-
dc.titleInterleukin 13 and interleukin 13 receptor are frequently expressed by Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1182/blood.V97.1.250-
dc.identifier.pmid11133768-
dc.identifier.scopuseid_2-s2.0-0035170688-
dc.identifier.volume97-
dc.identifier.issue1-
dc.identifier.spage250-
dc.identifier.epage255-
dc.identifier.isiWOS:000166177300032-
dc.identifier.issnl0006-4971-

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