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Article: T cell-specific loss of Pten leads to defects in central and peripheral tolerance

TitleT cell-specific loss of Pten leads to defects in central and peripheral tolerance
Authors
Issue Date2001
Citation
Immunity, 2001, v. 14, n. 5, p. 523-534 How to Cite?
AbstractPTEN, a tumor suppressor gene, is essential for embryogenesis. We used the Cre-loxP system to generate a T cell-specific deletion of the Pten gene (Ptenflox/- mice). All Ptenflox/- mice develop CD4+ T cell lymphomas by 17 weeks. Ptenflox/- mice show increased thymic cellularity due in part to a defect in thymic negative selection. Ptenflox/- mice exhibit elevated levels of B cells and CD4+ T cells in the periphery, spontaneous activation of CD4+ T cells, autoantibody production, and hypergammaglobulinemia. Ptenflox/- T cells hyperproliferate, are autoreactive, secrete increased levels of Th1/Th2 cytokines, resist apoptosis, and show increased phosphorylation of PKB/Akt and ERK. Peripheral tolerance to SEB is also impaired in Ptenflox/- mice. PTEN is thus an important regulator of T cell homeostasis and self-tolerance.
Persistent Identifierhttp://hdl.handle.net/10722/291561
ISSN
2023 Impact Factor: 25.5
2023 SCImago Journal Rankings: 13.578
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSuzuki, Akira-
dc.contributor.authorYamaguchi, Manae Tsukio-
dc.contributor.authorOhteki, Toshiaki-
dc.contributor.authorSasaki, Takehiko-
dc.contributor.authorKaisho, Tsuneyasu-
dc.contributor.authorKimura, Yuki-
dc.contributor.authorHiguchi, Tetsuya-
dc.contributor.authorFukumoto, Manabu-
dc.contributor.authorOhashi, Pamela S.-
dc.contributor.authorTsubata, Takeshi-
dc.contributor.authorKoyasu, Shigeo-
dc.contributor.authorNakano, Toru-
dc.contributor.authorMak, Tak W.-
dc.date.accessioned2020-11-17T14:54:38Z-
dc.date.available2020-11-17T14:54:38Z-
dc.date.issued2001-
dc.identifier.citationImmunity, 2001, v. 14, n. 5, p. 523-534-
dc.identifier.issn1074-7613-
dc.identifier.urihttp://hdl.handle.net/10722/291561-
dc.description.abstractPTEN, a tumor suppressor gene, is essential for embryogenesis. We used the Cre-loxP system to generate a T cell-specific deletion of the Pten gene (Ptenflox/- mice). All Ptenflox/- mice develop CD4+ T cell lymphomas by 17 weeks. Ptenflox/- mice show increased thymic cellularity due in part to a defect in thymic negative selection. Ptenflox/- mice exhibit elevated levels of B cells and CD4+ T cells in the periphery, spontaneous activation of CD4+ T cells, autoantibody production, and hypergammaglobulinemia. Ptenflox/- T cells hyperproliferate, are autoreactive, secrete increased levels of Th1/Th2 cytokines, resist apoptosis, and show increased phosphorylation of PKB/Akt and ERK. Peripheral tolerance to SEB is also impaired in Ptenflox/- mice. PTEN is thus an important regulator of T cell homeostasis and self-tolerance.-
dc.languageeng-
dc.relation.ispartofImmunity-
dc.titleT cell-specific loss of Pten leads to defects in central and peripheral tolerance-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/S1074-7613(01)00134-0-
dc.identifier.pmid11371355-
dc.identifier.scopuseid_2-s2.0-0034995242-
dc.identifier.volume14-
dc.identifier.issue5-
dc.identifier.spage523-
dc.identifier.epage534-
dc.identifier.isiWOS:000168880900005-
dc.identifier.issnl1074-7613-

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