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- Publisher Website: 10.1016/S1074-7613(01)00134-0
- Scopus: eid_2-s2.0-0034995242
- PMID: 11371355
- WOS: WOS:000168880900005
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Article: T cell-specific loss of Pten leads to defects in central and peripheral tolerance
Title | T cell-specific loss of Pten leads to defects in central and peripheral tolerance |
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Authors | |
Issue Date | 2001 |
Citation | Immunity, 2001, v. 14, n. 5, p. 523-534 How to Cite? |
Abstract | PTEN, a tumor suppressor gene, is essential for embryogenesis. We used the Cre-loxP system to generate a T cell-specific deletion of the Pten gene (Ptenflox/- mice). All Ptenflox/- mice develop CD4+ T cell lymphomas by 17 weeks. Ptenflox/- mice show increased thymic cellularity due in part to a defect in thymic negative selection. Ptenflox/- mice exhibit elevated levels of B cells and CD4+ T cells in the periphery, spontaneous activation of CD4+ T cells, autoantibody production, and hypergammaglobulinemia. Ptenflox/- T cells hyperproliferate, are autoreactive, secrete increased levels of Th1/Th2 cytokines, resist apoptosis, and show increased phosphorylation of PKB/Akt and ERK. Peripheral tolerance to SEB is also impaired in Ptenflox/- mice. PTEN is thus an important regulator of T cell homeostasis and self-tolerance. |
Persistent Identifier | http://hdl.handle.net/10722/291561 |
ISSN | 2023 Impact Factor: 25.5 2023 SCImago Journal Rankings: 13.578 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Suzuki, Akira | - |
dc.contributor.author | Yamaguchi, Manae Tsukio | - |
dc.contributor.author | Ohteki, Toshiaki | - |
dc.contributor.author | Sasaki, Takehiko | - |
dc.contributor.author | Kaisho, Tsuneyasu | - |
dc.contributor.author | Kimura, Yuki | - |
dc.contributor.author | Higuchi, Tetsuya | - |
dc.contributor.author | Fukumoto, Manabu | - |
dc.contributor.author | Ohashi, Pamela S. | - |
dc.contributor.author | Tsubata, Takeshi | - |
dc.contributor.author | Koyasu, Shigeo | - |
dc.contributor.author | Nakano, Toru | - |
dc.contributor.author | Mak, Tak W. | - |
dc.date.accessioned | 2020-11-17T14:54:38Z | - |
dc.date.available | 2020-11-17T14:54:38Z | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | Immunity, 2001, v. 14, n. 5, p. 523-534 | - |
dc.identifier.issn | 1074-7613 | - |
dc.identifier.uri | http://hdl.handle.net/10722/291561 | - |
dc.description.abstract | PTEN, a tumor suppressor gene, is essential for embryogenesis. We used the Cre-loxP system to generate a T cell-specific deletion of the Pten gene (Ptenflox/- mice). All Ptenflox/- mice develop CD4+ T cell lymphomas by 17 weeks. Ptenflox/- mice show increased thymic cellularity due in part to a defect in thymic negative selection. Ptenflox/- mice exhibit elevated levels of B cells and CD4+ T cells in the periphery, spontaneous activation of CD4+ T cells, autoantibody production, and hypergammaglobulinemia. Ptenflox/- T cells hyperproliferate, are autoreactive, secrete increased levels of Th1/Th2 cytokines, resist apoptosis, and show increased phosphorylation of PKB/Akt and ERK. Peripheral tolerance to SEB is also impaired in Ptenflox/- mice. PTEN is thus an important regulator of T cell homeostasis and self-tolerance. | - |
dc.language | eng | - |
dc.relation.ispartof | Immunity | - |
dc.title | T cell-specific loss of Pten leads to defects in central and peripheral tolerance | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1016/S1074-7613(01)00134-0 | - |
dc.identifier.pmid | 11371355 | - |
dc.identifier.scopus | eid_2-s2.0-0034995242 | - |
dc.identifier.volume | 14 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 523 | - |
dc.identifier.epage | 534 | - |
dc.identifier.isi | WOS:000168880900005 | - |
dc.identifier.issnl | 1074-7613 | - |