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Article: Regulation of PTEN transcription by p53

TitleRegulation of PTEN transcription by p53
Authors
Stambolic, V.MacPherson, D.Sas, D.Lin, Y.Snow, B.Jang, Y.Benchimol, S.Mak, T. W.
Issue Date2001
Citation
Molecular Cell, 2001, v. 8, n. 2, p. 317-325 How to Cite?
DOI: http://dx.doi.org/10.1016/S1097-2765(01)00323-9
AbstractPTEN tumor suppressor is frequently mutated in human cancers and is a negative regulator of PI3′K/PKB/Akt-dependent cellular survival. Investigation of the human genomic PTEN locus revealed a p53 binding element directly upstream of the PTEN gene. Deletion and mutation analyses showed that this element is necessary for inducible transactivation of PTEN by p53. A p53-independent element controlling constitutive expression of PTEN was also identified. In contrast to p53 mutant cell lines, induction of p53 in primary and tumor cell lines with wild-type p53 increased PTEN mRNA levels. PTEN was required for p53-mediated apoptosis in immortalized mouse embryonic fibroblasts. Our results reveal a unique role for p53 in regulation of cellular survival and an interesting connection in tumor suppressor signaling.
Persistent Identifierhttp://hdl.handle.net/10722/291556
ISSN
1097-2765
2021 Impact Factor: 19.328
2020 SCImago Journal Rankings: 12.615
ISI Accession Number ID
WOS:000170827000009

 

DC FieldValueLanguage
dc.contributor.authorStambolic, V.-
dc.contributor.authorMacPherson, D.-
dc.contributor.authorSas, D.-
dc.contributor.authorLin, Y.-
dc.contributor.authorSnow, B.-
dc.contributor.authorJang, Y.-
dc.contributor.authorBenchimol, S.-
dc.contributor.authorMak, T. W.-
dc.date.accessioned2020-11-17T14:54:37Z-
dc.date.available2020-11-17T14:54:37Z-
dc.date.issued2001-
dc.identifier.citationMolecular Cell, 2001, v. 8, n. 2, p. 317-325-
dc.identifier.issn1097-2765-
dc.identifier.urihttp://hdl.handle.net/10722/291556-
dc.description.abstractPTEN tumor suppressor is frequently mutated in human cancers and is a negative regulator of PI3′K/PKB/Akt-dependent cellular survival. Investigation of the human genomic PTEN locus revealed a p53 binding element directly upstream of the PTEN gene. Deletion and mutation analyses showed that this element is necessary for inducible transactivation of PTEN by p53. A p53-independent element controlling constitutive expression of PTEN was also identified. In contrast to p53 mutant cell lines, induction of p53 in primary and tumor cell lines with wild-type p53 increased PTEN mRNA levels. PTEN was required for p53-mediated apoptosis in immortalized mouse embryonic fibroblasts. Our results reveal a unique role for p53 in regulation of cellular survival and an interesting connection in tumor suppressor signaling.-
dc.languageeng-
dc.relation.ispartofMolecular Cell-
dc.titleRegulation of PTEN transcription by p53-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/S1097-2765(01)00323-9-
dc.identifier.pmid11545734-
dc.identifier.scopuseid_2-s2.0-0034854091-
dc.identifier.volume8-
dc.identifier.issue2-
dc.identifier.spage317-
dc.identifier.epage325-
dc.identifier.isiWOS:000170827000009-
dc.identifier.issnl1097-2765-

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