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Article: T-cell co-stimulation through B7RP-1 and ICOS

TitleT-cell co-stimulation through B7RP-1 and ICOS
Authors
Issue Date1999
Citation
Nature, 1999, v. 402, n. 6763, p. 827-830 How to Cite?
AbstractT-cell activation requires co-stimulation through receptors such as CD28 (refs 1-3) and antigen-specific signalling through the T-cell antigen receptor. Here we describe a new murine co-stimulatory receptor-ligand pair. The receptor, which is related to CD28 and is the homologue of the human protein ICOS, is expressed on activated T cells and resting memory T cells. The ligand, which has homology to B7 molecules and is called B7-related protein-1 (B7RP-1), is expressed on B cells and macrophages. ICOS and B7RP-1 do not interact with proteins in the CD28-B7 pathway, and B7RP-1 co- stimulates T cells in vitro independently of CD28. Transgenic mice expressing a B7RP-1Fc fusion protein show lymphoid hyperplasia in the spleen, lymph nodes and Peyer's patches. Presensitized mice treated with B7RP1-Fc during antigen challenge show enhanced hypersensitivity. Therefore, B7RP-1 exhibits co-stimulatory activities in vitro and in vivo. ICOS and B7RP-1 define a new and distinct receptor-ligand pair that is structurally related to CD28-B7 and is involved in the adaptive immune response.
Persistent Identifierhttp://hdl.handle.net/10722/291504
ISSN
2023 Impact Factor: 50.5
2023 SCImago Journal Rankings: 18.509
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYoshinaga, Steven K.-
dc.contributor.authorWhorlskey, John S.-
dc.contributor.authorKhare, Sanjay D.-
dc.contributor.authorSarmiento, Ulla-
dc.contributor.authorGuo, Jane-
dc.contributor.authorHoran, Tom-
dc.contributor.authorShih, Grace-
dc.contributor.authorZhang, Ming-
dc.contributor.authorCoccia, Marco A.-
dc.contributor.authorKohno, Tadahiko-
dc.contributor.authorTafuri-Bladt, Anna-
dc.contributor.authorBrankow, David-
dc.contributor.authorCampbell, Pauline-
dc.contributor.authorChang, David-
dc.contributor.authorChiu, Laura-
dc.contributor.authorDal, Tianang-
dc.contributor.authorDuncan, Gordon-
dc.contributor.authorElliott, Gary S.-
dc.contributor.authorHul, Ariela-
dc.contributor.authorMcCabe, Susan M.-
dc.contributor.authorScully, Sheila-
dc.contributor.authorShahinlan, Arda-
dc.contributor.authorShaklee, Christine L.-
dc.contributor.authorVan, Gwyneth-
dc.contributor.authorMak, Tak W.-
dc.contributor.authorSenaidi, Giorgio-
dc.date.accessioned2020-11-17T14:54:31Z-
dc.date.available2020-11-17T14:54:31Z-
dc.date.issued1999-
dc.identifier.citationNature, 1999, v. 402, n. 6763, p. 827-830-
dc.identifier.issn0028-0836-
dc.identifier.urihttp://hdl.handle.net/10722/291504-
dc.description.abstractT-cell activation requires co-stimulation through receptors such as CD28 (refs 1-3) and antigen-specific signalling through the T-cell antigen receptor. Here we describe a new murine co-stimulatory receptor-ligand pair. The receptor, which is related to CD28 and is the homologue of the human protein ICOS, is expressed on activated T cells and resting memory T cells. The ligand, which has homology to B7 molecules and is called B7-related protein-1 (B7RP-1), is expressed on B cells and macrophages. ICOS and B7RP-1 do not interact with proteins in the CD28-B7 pathway, and B7RP-1 co- stimulates T cells in vitro independently of CD28. Transgenic mice expressing a B7RP-1Fc fusion protein show lymphoid hyperplasia in the spleen, lymph nodes and Peyer's patches. Presensitized mice treated with B7RP1-Fc during antigen challenge show enhanced hypersensitivity. Therefore, B7RP-1 exhibits co-stimulatory activities in vitro and in vivo. ICOS and B7RP-1 define a new and distinct receptor-ligand pair that is structurally related to CD28-B7 and is involved in the adaptive immune response.-
dc.languageeng-
dc.relation.ispartofNature-
dc.titleT-cell co-stimulation through B7RP-1 and ICOS-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/45582-
dc.identifier.pmid10617205-
dc.identifier.scopuseid_2-s2.0-0033576707-
dc.identifier.volume402-
dc.identifier.issue6763-
dc.identifier.spage827-
dc.identifier.epage830-
dc.identifier.isiWOS:000084330500069-
dc.identifier.issnl0028-0836-

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