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Article: Differential requirement for p56(lck) in fetal and adult thymopoiesis

TitleDifferential requirement for p56(lck) in fetal and adult thymopoiesis
Authors
Issue Date1998
Citation
Journal of Immunology, 1998, v. 160, n. 8, p. 3828-3834 How to Cite?
AbstractThe protein tyrosine kinase p56(lck) is critical for the generation of mature thymocytes in adult mice. However its requirement during the maturation of thymocytes from the fetal to the adult stage has not been clearly defined. We analyzed prenatal and postnatal thymocyte maturation in mice deficient for p56(lck) (lck(-/-)). Before birth, lck appears to play a crucial role in the expansion and proliferation of CD4+CD8+ double positive thymocytes, whereas proliferation and absolute numbers of CD4-CD8- double negative thymocyte precursors remained within the normal range until the end of the second week postnatal. Three weeks after birth, the total numbers of double negative and immature single positive thymocytes underwent a dramatic reduction that correlated with a decrease in the double positive population. This ontogenic defect was associated with a significant decrease in the proliferation rates of thymocyte precursors. Our data suggest that signaling via p56(lck) kinase is differentially required within a given phenotypically defined thymocyte subpopulation, depending on its stage of thymocyte maturation.
Persistent Identifierhttp://hdl.handle.net/10722/291462
ISSN
2023 Impact Factor: 3.6
2023 SCImago Journal Rankings: 1.558
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMolina, Thierry J.-
dc.contributor.authorPerrot, Jean Yves-
dc.contributor.authorPenninger, Josef-
dc.contributor.authorRamos, Amélia-
dc.contributor.authorAudouin, Josée-
dc.contributor.authorBriand, Pascale-
dc.contributor.authorMak, Tak W.-
dc.contributor.authorDiebold, Jacques-
dc.date.accessioned2020-11-17T14:54:25Z-
dc.date.available2020-11-17T14:54:25Z-
dc.date.issued1998-
dc.identifier.citationJournal of Immunology, 1998, v. 160, n. 8, p. 3828-3834-
dc.identifier.issn0022-1767-
dc.identifier.urihttp://hdl.handle.net/10722/291462-
dc.description.abstractThe protein tyrosine kinase p56(lck) is critical for the generation of mature thymocytes in adult mice. However its requirement during the maturation of thymocytes from the fetal to the adult stage has not been clearly defined. We analyzed prenatal and postnatal thymocyte maturation in mice deficient for p56(lck) (lck(-/-)). Before birth, lck appears to play a crucial role in the expansion and proliferation of CD4+CD8+ double positive thymocytes, whereas proliferation and absolute numbers of CD4-CD8- double negative thymocyte precursors remained within the normal range until the end of the second week postnatal. Three weeks after birth, the total numbers of double negative and immature single positive thymocytes underwent a dramatic reduction that correlated with a decrease in the double positive population. This ontogenic defect was associated with a significant decrease in the proliferation rates of thymocyte precursors. Our data suggest that signaling via p56(lck) kinase is differentially required within a given phenotypically defined thymocyte subpopulation, depending on its stage of thymocyte maturation.-
dc.languageeng-
dc.relation.ispartofJournal of Immunology-
dc.titleDifferential requirement for p56(lck) in fetal and adult thymopoiesis-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid9558087-
dc.identifier.scopuseid_2-s2.0-0032521678-
dc.identifier.volume160-
dc.identifier.issue8-
dc.identifier.spage3828-
dc.identifier.epage3834-
dc.identifier.isiWOS:000072970400028-
dc.identifier.issnl0022-1767-

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