File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Developmental Studies of Brca1 and Brca2 Knock-Out Mice

TitleDevelopmental Studies of Brca1 and Brca2 Knock-Out Mice
Authors
KeywordsTrophoblast
Brca1
Cancer
Gastrulation
Brca2
Proliferation
Issue Date1998
Citation
Journal of Mammary Gland Biology and Neoplasia, 1998, v. 3, n. 4, p. 431-445 How to Cite?
AbstractIn humans, the inheritance of mutations in the breast cancer susceptibility genes BRCA1 and BRCA2 increases the risk of developing breast and ovarian cancer. To study their biological function and to create animal models for these cancer susceptibility genes, several strains of mice mutated in the homologous genes Brca1 and Brca2 have been generated by gene targeting. Analyses of these "knock-out" mouse mutants have provided invaluable knowledge about the function of these genes. Brca1 and Brca2 null mutants are similar in phenotype: mutations in both genes result in embryonic lethality and the developing embryos show signs of a cellular proliferation defect associated with activation of the p53 pathway. The significance of this activation, as well as the role of these cancer susceptibility genes in DNA damage repair, is discussed.
Persistent Identifierhttp://hdl.handle.net/10722/291452
ISSN
2023 Impact Factor: 3.0
2023 SCImago Journal Rankings: 0.964
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHakem, Razqallah-
dc.contributor.authorDe La Pompa, José Luis-
dc.contributor.authorMak, Tak W.-
dc.date.accessioned2020-11-17T14:54:24Z-
dc.date.available2020-11-17T14:54:24Z-
dc.date.issued1998-
dc.identifier.citationJournal of Mammary Gland Biology and Neoplasia, 1998, v. 3, n. 4, p. 431-445-
dc.identifier.issn1083-3021-
dc.identifier.urihttp://hdl.handle.net/10722/291452-
dc.description.abstractIn humans, the inheritance of mutations in the breast cancer susceptibility genes BRCA1 and BRCA2 increases the risk of developing breast and ovarian cancer. To study their biological function and to create animal models for these cancer susceptibility genes, several strains of mice mutated in the homologous genes Brca1 and Brca2 have been generated by gene targeting. Analyses of these "knock-out" mouse mutants have provided invaluable knowledge about the function of these genes. Brca1 and Brca2 null mutants are similar in phenotype: mutations in both genes result in embryonic lethality and the developing embryos show signs of a cellular proliferation defect associated with activation of the p53 pathway. The significance of this activation, as well as the role of these cancer susceptibility genes in DNA damage repair, is discussed.-
dc.languageeng-
dc.relation.ispartofJournal of Mammary Gland Biology and Neoplasia-
dc.subjectTrophoblast-
dc.subjectBrca1-
dc.subjectCancer-
dc.subjectGastrulation-
dc.subjectBrca2-
dc.subjectProliferation-
dc.titleDevelopmental Studies of Brca1 and Brca2 Knock-Out Mice-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1023/A:1018792200700-
dc.identifier.pmid10819537-
dc.identifier.scopuseid_2-s2.0-0032173693-
dc.identifier.volume3-
dc.identifier.issue4-
dc.identifier.spage431-
dc.identifier.epage445-
dc.identifier.isiWOS:000077148600008-
dc.identifier.issnl1083-3021-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats