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- Publisher Website: 10.1006/cimm.1996.1041
- Scopus: eid_2-s2.0-0031561772
- PMID: 9015183
- WOS: WOS:A1997WC93800002
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Article: T-cell-independent antiviral B cell responses in CD45-deficient mice
Title | T-cell-independent antiviral B cell responses in CD45-deficient mice |
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Authors | |
Issue Date | 1997 |
Citation | Cellular Immunology, 1997, v. 175, n. 1, p. 12-15 How to Cite? |
Abstract | CD45 is expressed on all B cells and has been reported to be essential for their B cell receptor mediated stimulation. The present study addressed T-cell-independent B cell responses in CD45-deficient mice using the glycoprotein (G) of vesicular stomatitis virus (VSV) as a model antigen. VSV-G exists in two forms exhibiting different degrees of repetitiveness. In mice, the two forms of VSV-G induce either a type 1 or a type 2 T-cell-independent B cell response. We found that CD45-deficient mice mounted T-cell-independent B cell responses to both forms of VSV-G. This demonstrates that the B cell receptor complex is able to generate a functional signal in the absence of CD45, provided the cross-linking stimulus is sufficiently strong. |
Persistent Identifier | http://hdl.handle.net/10722/291431 |
ISSN | 2023 Impact Factor: 3.7 2023 SCImago Journal Rankings: 1.011 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Bachmann, Martin F. | - |
dc.contributor.author | Kündig, Thomas M. | - |
dc.contributor.author | Speiser, Daniel E. | - |
dc.contributor.author | McKall-Faienza, Kim | - |
dc.contributor.author | Kishara, Kenji | - |
dc.contributor.author | Mak, Tak W. | - |
dc.contributor.author | Ohashi, Pamela S. | - |
dc.date.accessioned | 2020-11-17T14:54:21Z | - |
dc.date.available | 2020-11-17T14:54:21Z | - |
dc.date.issued | 1997 | - |
dc.identifier.citation | Cellular Immunology, 1997, v. 175, n. 1, p. 12-15 | - |
dc.identifier.issn | 0008-8749 | - |
dc.identifier.uri | http://hdl.handle.net/10722/291431 | - |
dc.description.abstract | CD45 is expressed on all B cells and has been reported to be essential for their B cell receptor mediated stimulation. The present study addressed T-cell-independent B cell responses in CD45-deficient mice using the glycoprotein (G) of vesicular stomatitis virus (VSV) as a model antigen. VSV-G exists in two forms exhibiting different degrees of repetitiveness. In mice, the two forms of VSV-G induce either a type 1 or a type 2 T-cell-independent B cell response. We found that CD45-deficient mice mounted T-cell-independent B cell responses to both forms of VSV-G. This demonstrates that the B cell receptor complex is able to generate a functional signal in the absence of CD45, provided the cross-linking stimulus is sufficiently strong. | - |
dc.language | eng | - |
dc.relation.ispartof | Cellular Immunology | - |
dc.title | T-cell-independent antiviral B cell responses in CD45-deficient mice | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1006/cimm.1996.1041 | - |
dc.identifier.pmid | 9015183 | - |
dc.identifier.scopus | eid_2-s2.0-0031561772 | - |
dc.identifier.volume | 175 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 12 | - |
dc.identifier.epage | 15 | - |
dc.identifier.isi | WOS:A1997WC93800002 | - |
dc.identifier.issnl | 0008-8749 | - |