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- Publisher Website: 10.1128/jvi.71.4.3013-3022.1997
- Scopus: eid_2-s2.0-0030933216
- PMID: 9060661
- WOS: WOS:A1997WM91100053
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Article: Studies of the susceptibility of nude, CD4 knockout, and SCID mutant mice to the disease induced by the murine AIDS defective virus
Title | Studies of the susceptibility of nude, CD4 knockout, and SCID mutant mice to the disease induced by the murine AIDS defective virus |
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Authors | |
Issue Date | 1997 |
Citation | Journal of Virology, 1997, v. 71, n. 4, p. 3013-3022 How to Cite? |
Abstract | Murine AIDS (MAIDS) is induced by a defective retrovirus that infects lymphocyte cells of the B lineage. To determine whether functional T cells are required for the infection of B cells, T-cell-deficient mice (nude, CD4 knockout, and SCID) were infected with helper-free stocks of the MAIDS defective virus. Infection of B cells was monitored by Northern blot analysis and in situ hybridization. The C57BL/6 nude mice contained clusters of infected B cells, but less so than did the euthymic mice. In contrast, the (C57BL/6 x BALB/c)F1 nude mice harbored more infected B cells than did their euthymic littermates when maintained in a pathogen-free environment. Clusters of infected B cells were also detected in the MAIDS virus-infected CD4(-/-) knockout mice despite the total absence of CD4+ T cells in these mice. However, infected cells were not detected in SCID mice (deficient in mature T and B cells) inoculated with the same virus, indicating that precursor B cells are not a target of the virus in the absence of mature CD4+ T cells. These data confirm that the primary event in the development of MAIDS is the infection of relatively mature peripheral B cells and that CD4+ T cells are required to promote the expansion of these infected B cells. |
Persistent Identifier | http://hdl.handle.net/10722/291414 |
ISSN | 2023 Impact Factor: 4.0 2023 SCImago Journal Rankings: 1.378 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Simard, Carole | - |
dc.contributor.author | Klein, Steven J. | - |
dc.contributor.author | Mak, Tak | - |
dc.contributor.author | Jolicoeur, Paul | - |
dc.date.accessioned | 2020-11-17T14:54:19Z | - |
dc.date.available | 2020-11-17T14:54:19Z | - |
dc.date.issued | 1997 | - |
dc.identifier.citation | Journal of Virology, 1997, v. 71, n. 4, p. 3013-3022 | - |
dc.identifier.issn | 0022-538X | - |
dc.identifier.uri | http://hdl.handle.net/10722/291414 | - |
dc.description.abstract | Murine AIDS (MAIDS) is induced by a defective retrovirus that infects lymphocyte cells of the B lineage. To determine whether functional T cells are required for the infection of B cells, T-cell-deficient mice (nude, CD4 knockout, and SCID) were infected with helper-free stocks of the MAIDS defective virus. Infection of B cells was monitored by Northern blot analysis and in situ hybridization. The C57BL/6 nude mice contained clusters of infected B cells, but less so than did the euthymic mice. In contrast, the (C57BL/6 x BALB/c)F1 nude mice harbored more infected B cells than did their euthymic littermates when maintained in a pathogen-free environment. Clusters of infected B cells were also detected in the MAIDS virus-infected CD4(-/-) knockout mice despite the total absence of CD4+ T cells in these mice. However, infected cells were not detected in SCID mice (deficient in mature T and B cells) inoculated with the same virus, indicating that precursor B cells are not a target of the virus in the absence of mature CD4+ T cells. These data confirm that the primary event in the development of MAIDS is the infection of relatively mature peripheral B cells and that CD4+ T cells are required to promote the expansion of these infected B cells. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Virology | - |
dc.title | Studies of the susceptibility of nude, CD4 knockout, and SCID mutant mice to the disease induced by the murine AIDS defective virus | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1128/jvi.71.4.3013-3022.1997 | - |
dc.identifier.pmid | 9060661 | - |
dc.identifier.pmcid | PMC191430 | - |
dc.identifier.scopus | eid_2-s2.0-0030933216 | - |
dc.identifier.volume | 71 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 3013 | - |
dc.identifier.epage | 3022 | - |
dc.identifier.isi | WOS:A1997WM91100053 | - |
dc.identifier.issnl | 0022-538X | - |