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- Publisher Website: 10.1002/eji.1830270811
- Scopus: eid_2-s2.0-0030740572
- PMID: 9295023
- WOS: WOS:A1997XQ08000010
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Article: Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice
Title | Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice |
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Authors | |
Keywords | T cell receptor transgenic Negative selection CTLA-4 |
Issue Date | 1997 |
Citation | European Journal of Immunology, 1997, v. 27, n. 8, p. 1887-1892 How to Cite? |
Abstract | CTLA-4 is a T cell surface receptor essential for the negative regulation of T cell activation. In the CTLA-4-deficient mouse, a dramatic accumulation of activated peripheral T cells effects extensive damage to host tissues, resulting in mortality within 5 weeks of age. To determine whether the accumulation of activated T cells in CTLA-4(-/-) mice is due to a defect in thymic selection, we examined negative selection in CTLA-4(-/-) mice using two transgenic T cell receptor (TCR) models of thymic selection. Neither the H-Y-specific TCR nor the lymphocytic choriomeningitis virus (LCMV)-specific TCR transgenic models revealed a defect in positive or negative selection in CTLA-(4-/-) mice in vivo or in vitro. In fact, the negatively selecting phenotype of male H-YTCR-transgenic mice greatly mitigated the accumulation of activated peripheral T cells. Further, peripheral CTLA-4(-/-) T cells expressing a single LMCV-specific transgenic TCR did not have an activated phenotype, indicating that CTLA-4(-/-) T cells require specific antigen for proliferation. These results demonstrate that specific antigen is required for the lymphoproliferation observed in CTLA-4(-/-) mice, and that CTLA-4 deficiency does not lead to a gross defect in negative selection. |
Persistent Identifier | http://hdl.handle.net/10722/291395 |
ISSN | 2023 Impact Factor: 4.5 2023 SCImago Journal Rankings: 1.627 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Waterhouse, Paul | - |
dc.contributor.author | Bachmann, Martin F. | - |
dc.contributor.author | Penninger, Josef M. | - |
dc.contributor.author | Ohashi, Pamela S. | - |
dc.contributor.author | Mak, Tak W. | - |
dc.date.accessioned | 2020-11-17T14:54:16Z | - |
dc.date.available | 2020-11-17T14:54:16Z | - |
dc.date.issued | 1997 | - |
dc.identifier.citation | European Journal of Immunology, 1997, v. 27, n. 8, p. 1887-1892 | - |
dc.identifier.issn | 0014-2980 | - |
dc.identifier.uri | http://hdl.handle.net/10722/291395 | - |
dc.description.abstract | CTLA-4 is a T cell surface receptor essential for the negative regulation of T cell activation. In the CTLA-4-deficient mouse, a dramatic accumulation of activated peripheral T cells effects extensive damage to host tissues, resulting in mortality within 5 weeks of age. To determine whether the accumulation of activated T cells in CTLA-4(-/-) mice is due to a defect in thymic selection, we examined negative selection in CTLA-4(-/-) mice using two transgenic T cell receptor (TCR) models of thymic selection. Neither the H-Y-specific TCR nor the lymphocytic choriomeningitis virus (LCMV)-specific TCR transgenic models revealed a defect in positive or negative selection in CTLA-(4-/-) mice in vivo or in vitro. In fact, the negatively selecting phenotype of male H-YTCR-transgenic mice greatly mitigated the accumulation of activated peripheral T cells. Further, peripheral CTLA-4(-/-) T cells expressing a single LMCV-specific transgenic TCR did not have an activated phenotype, indicating that CTLA-4(-/-) T cells require specific antigen for proliferation. These results demonstrate that specific antigen is required for the lymphoproliferation observed in CTLA-4(-/-) mice, and that CTLA-4 deficiency does not lead to a gross defect in negative selection. | - |
dc.language | eng | - |
dc.relation.ispartof | European Journal of Immunology | - |
dc.subject | T cell receptor transgenic | - |
dc.subject | Negative selection | - |
dc.subject | CTLA-4 | - |
dc.title | Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1002/eji.1830270811 | - |
dc.identifier.pmid | 9295023 | - |
dc.identifier.scopus | eid_2-s2.0-0030740572 | - |
dc.identifier.volume | 27 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 1887 | - |
dc.identifier.epage | 1892 | - |
dc.identifier.isi | WOS:A1997XQ08000010 | - |
dc.identifier.issnl | 0014-2980 | - |