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- Publisher Website: 10.1159/000149048
- Scopus: eid_2-s2.0-0018375048
- PMID: 88425
- WOS: WOS:A1979GS48700006
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Article: Inhibition of murine sarcoma virus-induced foci formation by cytidine analogues and other drugs chemotherapeutically effective in human malignancies
Title | Inhibition of murine sarcoma virus-induced foci formation by cytidine analogues and other drugs chemotherapeutically effective in human malignancies |
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Authors | |
Issue Date | 1979 |
Citation | Intervirology, 1979, v. 11, n. 5, p. 291-299 How to Cite? |
Abstract | The present report describes an in vitro culture system using the Kirsten murine sarcoma virus transformation focus assay to evaluate the antiviral activities of 12 commonly used chemotherapeutically effective drugs. Since these drugs are cytotoxic, the plating efficiencies of the cells treated were monitored simultaneously. Using this procedure, Adriamycin, Daunorubicin, Bleomycin, Camptothecin, Mithramycin, hydroxyurea, 5-fluorouracil, thioguanine, 9-β-D-arabinofuranosyladenine, 1-β-D-arabinofuranosylcytosine (ara-C), azacytidine and cyclocytidine were tested. Of all these compounds tested only the cytidine analogues - cyclocytidine, ara-C, and to a lesser extent, azacytidine - showed selective effect on inhibition of viral foci over cytotoxicity. Studies on the duration of exposure to ara-C indicated that an exposure time of 10-30 h produced the most pronounced effect on the inhibition of foci formation over that of cytotoxicity. |
Persistent Identifier | http://hdl.handle.net/10722/291371 |
ISSN | 2023 Impact Factor: 3.2 2023 SCImago Journal Rankings: 0.556 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wan, C. W. | - |
dc.contributor.author | Mak, T. W. | - |
dc.date.accessioned | 2020-11-17T14:54:13Z | - |
dc.date.available | 2020-11-17T14:54:13Z | - |
dc.date.issued | 1979 | - |
dc.identifier.citation | Intervirology, 1979, v. 11, n. 5, p. 291-299 | - |
dc.identifier.issn | 0300-5526 | - |
dc.identifier.uri | http://hdl.handle.net/10722/291371 | - |
dc.description.abstract | The present report describes an in vitro culture system using the Kirsten murine sarcoma virus transformation focus assay to evaluate the antiviral activities of 12 commonly used chemotherapeutically effective drugs. Since these drugs are cytotoxic, the plating efficiencies of the cells treated were monitored simultaneously. Using this procedure, Adriamycin, Daunorubicin, Bleomycin, Camptothecin, Mithramycin, hydroxyurea, 5-fluorouracil, thioguanine, 9-β-D-arabinofuranosyladenine, 1-β-D-arabinofuranosylcytosine (ara-C), azacytidine and cyclocytidine were tested. Of all these compounds tested only the cytidine analogues - cyclocytidine, ara-C, and to a lesser extent, azacytidine - showed selective effect on inhibition of viral foci over cytotoxicity. Studies on the duration of exposure to ara-C indicated that an exposure time of 10-30 h produced the most pronounced effect on the inhibition of foci formation over that of cytotoxicity. | - |
dc.language | eng | - |
dc.relation.ispartof | Intervirology | - |
dc.title | Inhibition of murine sarcoma virus-induced foci formation by cytidine analogues and other drugs chemotherapeutically effective in human malignancies | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1159/000149048 | - |
dc.identifier.pmid | 88425 | - |
dc.identifier.scopus | eid_2-s2.0-0018375048 | - |
dc.identifier.volume | 11 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 291 | - |
dc.identifier.epage | 299 | - |
dc.identifier.isi | WOS:A1979GS48700006 | - |
dc.identifier.issnl | 0300-5526 | - |