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- Publisher Website: 10.3389/fgene.2020.01008
- Scopus: eid_2-s2.0-85091202471
- PMID: 33088282
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Article: Identification of Cooperative Gene Regulation Among Transcription Factors, LncRNAs, and MicroRNAs in Diabetic Nephropathy Progression
Title | Identification of Cooperative Gene Regulation Among Transcription Factors, LncRNAs, and MicroRNAs in Diabetic Nephropathy Progression |
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Authors | |
Keywords | diabetic nephropathy long non-coding RNAs microRNAs regulatory interactions transcription factors |
Issue Date | 2020 |
Publisher | Frontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/genetics |
Citation | Frontiers in Genetics, 2020, v. 11, p. article no. 1008 How to Cite? |
Abstract | The pathogenesis of diabetic nephropathy (DN) is accompanied by alterations in biological function and signaling pathways regulated through complex molecular mechanisms. A number of regulatory factors, including transcription factors (TFs) and non-coding RNAs (ncRNAs, including lncRNAs and miRNAs), have been implicated in DN; however, it is unclear how the interactions among these regulatory factors contribute to the development of DN pathogenesis. In this study, we developed a network-based analysis to decipher interplays between TFs and ncRNAs regulating progression of DN by combining omics data with regulatory factor-target information. To accomplish this, we identified differential expression programs of mRNAs and miRNAs during early DN (EDN) and established DN. We then uncovered putative interactive connections among miRNA–mRNA, lncRNA–miRNA, and lncRNA–mRNA implicated in transcriptional control. This led to the identification of two lncRNAs (MALAT1 and NEAT1) and the three TFs (NF-κB, NFE2L2, and PPARG) that likely cooperate with a set of miRNAs to modulate EDN and DN target genes. The results highlight how crosstalk among TFs, lncRNAs, and miRNAs regulate the expression of genes both transcriptionally and post-transcriptionally, and our findings provide new insights into the molecular basis and pathogenesis of progressive DN. |
Persistent Identifier | http://hdl.handle.net/10722/291050 |
ISSN | 2023 Impact Factor: 2.8 2023 SCImago Journal Rankings: 0.853 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chen, L | - |
dc.contributor.author | Wu, B | - |
dc.contributor.author | Wang, S | - |
dc.contributor.author | Xiong, Y | - |
dc.contributor.author | Zhou, B | - |
dc.contributor.author | Cheng, X | - |
dc.contributor.author | Zhou, T | - |
dc.contributor.author | Luo, R | - |
dc.contributor.author | Lam, TW | - |
dc.contributor.author | Yan, B | - |
dc.contributor.author | Chen, J | - |
dc.date.accessioned | 2020-11-02T05:50:51Z | - |
dc.date.available | 2020-11-02T05:50:51Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Frontiers in Genetics, 2020, v. 11, p. article no. 1008 | - |
dc.identifier.issn | 1664-8021 | - |
dc.identifier.uri | http://hdl.handle.net/10722/291050 | - |
dc.description.abstract | The pathogenesis of diabetic nephropathy (DN) is accompanied by alterations in biological function and signaling pathways regulated through complex molecular mechanisms. A number of regulatory factors, including transcription factors (TFs) and non-coding RNAs (ncRNAs, including lncRNAs and miRNAs), have been implicated in DN; however, it is unclear how the interactions among these regulatory factors contribute to the development of DN pathogenesis. In this study, we developed a network-based analysis to decipher interplays between TFs and ncRNAs regulating progression of DN by combining omics data with regulatory factor-target information. To accomplish this, we identified differential expression programs of mRNAs and miRNAs during early DN (EDN) and established DN. We then uncovered putative interactive connections among miRNA–mRNA, lncRNA–miRNA, and lncRNA–mRNA implicated in transcriptional control. This led to the identification of two lncRNAs (MALAT1 and NEAT1) and the three TFs (NF-κB, NFE2L2, and PPARG) that likely cooperate with a set of miRNAs to modulate EDN and DN target genes. The results highlight how crosstalk among TFs, lncRNAs, and miRNAs regulate the expression of genes both transcriptionally and post-transcriptionally, and our findings provide new insights into the molecular basis and pathogenesis of progressive DN. | - |
dc.language | eng | - |
dc.publisher | Frontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/genetics | - |
dc.relation.ispartof | Frontiers in Genetics | - |
dc.rights | This Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | diabetic nephropathy | - |
dc.subject | long non-coding RNAs | - |
dc.subject | microRNAs | - |
dc.subject | regulatory interactions | - |
dc.subject | transcription factors | - |
dc.title | Identification of Cooperative Gene Regulation Among Transcription Factors, LncRNAs, and MicroRNAs in Diabetic Nephropathy Progression | - |
dc.type | Article | - |
dc.identifier.email | Luo, R: rbluo@cs.hku.hk | - |
dc.identifier.email | Lam, TW: twlam@cs.hku.hk | - |
dc.identifier.email | Yan, B: yanbin14@hku.hk | - |
dc.identifier.authority | Luo, R=rp02360 | - |
dc.identifier.authority | Lam, TW=rp00135 | - |
dc.identifier.authority | Yan, B=rp01940 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3389/fgene.2020.01008 | - |
dc.identifier.pmid | 33088282 | - |
dc.identifier.pmcid | PMC7490338 | - |
dc.identifier.scopus | eid_2-s2.0-85091202471 | - |
dc.identifier.hkuros | 318147 | - |
dc.identifier.volume | 11 | - |
dc.identifier.spage | article no. 1008 | - |
dc.identifier.epage | article no. 1008 | - |
dc.identifier.isi | WOS:000570621300001 | - |
dc.publisher.place | Switzerland | - |
dc.identifier.issnl | 1664-8021 | - |