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Article: Fecal microbiota transplantation confers beneficial metabolic effects of diet and exercise on diet-induced obese mice

TitleFecal microbiota transplantation confers beneficial metabolic effects of diet and exercise on diet-induced obese mice
Authors
KeywordsFecal Microbiota Transplantation (FMT)
Odoribacter
Food Efficacy
Intraperitoneal Glucose Tolerance Test (IPGTT)
LDA) Effect Size (LEfSe)
Issue Date2018
PublisherNature Research (part of Springer Nature): Fully open access journals. The Journal's web site is located at http://www.nature.com/srep/index.html
Citation
Scientific Reports, 2018, v. 8, p. article no. 15625 How to Cite?
AbstractDiet and exercise are conventional methods for controlling body weight and are linked to alterations in gut microbiota. However, the associations of diet, exercise, and gut microbiota in the control of obesity remain largely unknown. In the present study, using 16S rRNA amplicon sequencing and fecal microbiota transplantation (FMT), normal fat diet (NFD), exercise and their combination resulted in improved metabolic profiles in comparison to sedentary lifestyle with high fat diet (HFD). Moreover, diet exerted more influence than exercise in shaping the gut microbiota. HFD-fed mice receiving FMT from NFD-exercised donors not only showed remarkably reduced food efficacy, but also mitigated metabolic profiles (p < 0.05). The transmissible beneficial effects of FMT were associated with bacterial genera Helicobacter, Odoribacter and AF12 and overrepresentation of oxidative phosphorylation and glycolysis genes. Our findings demonstrate that the beneficial effects of diet and exercise are transmissible via FMT, suggesting a potential therapeutic treatment for obesity.
Persistent Identifierhttp://hdl.handle.net/10722/290938
ISSN
2023 Impact Factor: 3.8
2023 SCImago Journal Rankings: 0.900
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLai, ZL-
dc.contributor.authorTseng, CH-
dc.contributor.authorHo, HJ-
dc.contributor.authorCheung, CKY-
dc.contributor.authorLin, JY-
dc.contributor.authorChen, YJ-
dc.contributor.authorCheng, FC-
dc.contributor.authorHsu, YC-
dc.contributor.authorLin, JT-
dc.contributor.authorEl-Omar, EM-
dc.contributor.authorWu, CY-
dc.date.accessioned2020-11-02T05:49:14Z-
dc.date.available2020-11-02T05:49:14Z-
dc.date.issued2018-
dc.identifier.citationScientific Reports, 2018, v. 8, p. article no. 15625-
dc.identifier.issn2045-2322-
dc.identifier.urihttp://hdl.handle.net/10722/290938-
dc.description.abstractDiet and exercise are conventional methods for controlling body weight and are linked to alterations in gut microbiota. However, the associations of diet, exercise, and gut microbiota in the control of obesity remain largely unknown. In the present study, using 16S rRNA amplicon sequencing and fecal microbiota transplantation (FMT), normal fat diet (NFD), exercise and their combination resulted in improved metabolic profiles in comparison to sedentary lifestyle with high fat diet (HFD). Moreover, diet exerted more influence than exercise in shaping the gut microbiota. HFD-fed mice receiving FMT from NFD-exercised donors not only showed remarkably reduced food efficacy, but also mitigated metabolic profiles (p < 0.05). The transmissible beneficial effects of FMT were associated with bacterial genera Helicobacter, Odoribacter and AF12 and overrepresentation of oxidative phosphorylation and glycolysis genes. Our findings demonstrate that the beneficial effects of diet and exercise are transmissible via FMT, suggesting a potential therapeutic treatment for obesity.-
dc.languageeng-
dc.publisherNature Research (part of Springer Nature): Fully open access journals. The Journal's web site is located at http://www.nature.com/srep/index.html-
dc.relation.ispartofScientific Reports-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectFecal Microbiota Transplantation (FMT)-
dc.subjectOdoribacter-
dc.subjectFood Efficacy-
dc.subjectIntraperitoneal Glucose Tolerance Test (IPGTT)-
dc.subjectLDA) Effect Size (LEfSe)-
dc.titleFecal microbiota transplantation confers beneficial metabolic effects of diet and exercise on diet-induced obese mice-
dc.typeArticle-
dc.identifier.emailCheung, CKY: ckyc@hku.hk-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/s41598-018-33893-y-
dc.identifier.pmid30353027-
dc.identifier.pmcidPMC6199268-
dc.identifier.scopuseid_2-s2.0-85055604213-
dc.identifier.hkuros318312-
dc.identifier.volume8-
dc.identifier.spagearticle no. 15625-
dc.identifier.epagearticle no. 15625-
dc.identifier.isiWOS:000448049400022-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl2045-2322-

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