File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Local and systemic treatment for HER2-positive breast cancer with brain metastases: a comprehensive review

TitleLocal and systemic treatment for HER2-positive breast cancer with brain metastases: a comprehensive review
Authors
Chan, WLLam, TCLam, KOLuk, MYNgan, RKCKwong, D
KeywordsHER2+ breast cancer
HER2-targeted therapy
metastatic brain tumours
radiotherapy
tyrosine kinase inhibitor
Issue Date2020
PublisherSAGE Publications (UK and US): Open Access Titles. The Journal's web site is located at https://journals.sagepub.com/home/tama
Citation
Therapeutic Advances in Medical Oncology, 2020, v. 12, p. 1-14 How to Cite?
DOI: http://dx.doi.org/10.1177/1758835920953729
AbstractThe management of human epidermal growth factor receptor (HER2)-positive breast cancer has improved over the past decade. However, despite improvements in systemic control, a substantial proportion of patients with advanced HER2-positive breast cancer suffer from central nervous system metastases and even intracranial progression after aggressive local treatment. There is paucity of data and no consensus on the systemic therapies for patients with intracranial progression. This review discusses both local and systemic treatments for HER2-positive breast cancer with brain metastases with a special focus on the response of central nervous system metastases. A recommended practical treatment algorithm to guide physicians in selecting the most appropriate anti-HER2 therapy for their patients is suggested.
Persistent Identifierhttp://hdl.handle.net/10722/290888
ISSN
1758-8340
2023 Impact Factor: 4.3
2023 SCImago Journal Rankings: 1.529
ISI Accession Number ID
WOS:000570708300001

 

DC FieldValueLanguage
dc.contributor.authorChan, WL-
dc.contributor.authorLam, TC-
dc.contributor.authorLam, KO-
dc.contributor.authorLuk, MY-
dc.contributor.authorNgan, RKC-
dc.contributor.authorKwong, D-
dc.date.accessioned2020-11-02T05:48:31Z-
dc.date.available2020-11-02T05:48:31Z-
dc.date.issued2020-
dc.identifier.citationTherapeutic Advances in Medical Oncology, 2020, v. 12, p. 1-14-
dc.identifier.issn1758-8340-
dc.identifier.urihttp://hdl.handle.net/10722/290888-
dc.description.abstractThe management of human epidermal growth factor receptor (HER2)-positive breast cancer has improved over the past decade. However, despite improvements in systemic control, a substantial proportion of patients with advanced HER2-positive breast cancer suffer from central nervous system metastases and even intracranial progression after aggressive local treatment. There is paucity of data and no consensus on the systemic therapies for patients with intracranial progression. This review discusses both local and systemic treatments for HER2-positive breast cancer with brain metastases with a special focus on the response of central nervous system metastases. A recommended practical treatment algorithm to guide physicians in selecting the most appropriate anti-HER2 therapy for their patients is suggested.-
dc.languageeng-
dc.publisherSAGE Publications (UK and US): Open Access Titles. The Journal's web site is located at https://journals.sagepub.com/home/tama-
dc.relation.ispartofTherapeutic Advances in Medical Oncology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectHER2+ breast cancer-
dc.subjectHER2-targeted therapy-
dc.subjectmetastatic brain tumours-
dc.subjectradiotherapy-
dc.subjecttyrosine kinase inhibitor-
dc.titleLocal and systemic treatment for HER2-positive breast cancer with brain metastases: a comprehensive review-
dc.typeArticle-
dc.identifier.emailChan, WL: winglok@hku.hk-
dc.identifier.emailLam, TC: lamtc03@hku.hk-
dc.identifier.emailLam, KO: lamkaon@hku.hk-
dc.identifier.emailNgan, RKC: rkcngan@hku.hk-
dc.identifier.emailKwong, D: dlwkwong@hku.hk-
dc.identifier.authorityChan, WL=rp02541-
dc.identifier.authorityLam, TC=rp02128-
dc.identifier.authorityLam, KO=rp01501-
dc.identifier.authorityNgan, RKC=rp02371-
dc.identifier.authorityKwong, D=rp00414-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1177/1758835920953729-
dc.identifier.scopuseid_2-s2.0-85090976353-
dc.identifier.hkuros317868-
dc.identifier.hkuros314686-
dc.identifier.hkuros314846-
dc.identifier.hkuros314866-
dc.identifier.volume12-
dc.identifier.spage1-
dc.identifier.epage14-
dc.identifier.isiWOS:000570708300001-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl1758-8340-

Export via OAI-PMH Interface in XML Formats

OR

Export to Other Non-XML Formats