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Article: Local and systemic treatment for HER2-positive breast cancer with brain metastases: a comprehensive review
Title | Local and systemic treatment for HER2-positive breast cancer with brain metastases: a comprehensive review |
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Authors | |
Keywords | HER2+ breast cancer HER2-targeted therapy metastatic brain tumours radiotherapy tyrosine kinase inhibitor |
Issue Date | 2020 |
Publisher | SAGE Publications (UK and US): Open Access Titles. The Journal's web site is located at https://journals.sagepub.com/home/tama |
Citation | Therapeutic Advances in Medical Oncology, 2020, v. 12, p. 1-14 How to Cite? |
Abstract | The management of human epidermal growth factor receptor (HER2)-positive breast cancer has improved over the past decade. However, despite improvements in systemic control, a substantial proportion of patients with advanced HER2-positive breast cancer suffer from central nervous system metastases and even intracranial progression after aggressive local treatment. There is paucity of data and no consensus on the systemic therapies for patients with intracranial progression. This review discusses both local and systemic treatments for HER2-positive breast cancer with brain metastases with a special focus on the response of central nervous system metastases. A recommended practical treatment algorithm to guide physicians in selecting the most appropriate anti-HER2 therapy for their patients is suggested. |
Persistent Identifier | http://hdl.handle.net/10722/290888 |
ISSN | 2023 Impact Factor: 4.3 2023 SCImago Journal Rankings: 1.529 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chan, WL | - |
dc.contributor.author | Lam, TC | - |
dc.contributor.author | Lam, KO | - |
dc.contributor.author | Luk, MY | - |
dc.contributor.author | Ngan, RKC | - |
dc.contributor.author | Kwong, D | - |
dc.date.accessioned | 2020-11-02T05:48:31Z | - |
dc.date.available | 2020-11-02T05:48:31Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Therapeutic Advances in Medical Oncology, 2020, v. 12, p. 1-14 | - |
dc.identifier.issn | 1758-8340 | - |
dc.identifier.uri | http://hdl.handle.net/10722/290888 | - |
dc.description.abstract | The management of human epidermal growth factor receptor (HER2)-positive breast cancer has improved over the past decade. However, despite improvements in systemic control, a substantial proportion of patients with advanced HER2-positive breast cancer suffer from central nervous system metastases and even intracranial progression after aggressive local treatment. There is paucity of data and no consensus on the systemic therapies for patients with intracranial progression. This review discusses both local and systemic treatments for HER2-positive breast cancer with brain metastases with a special focus on the response of central nervous system metastases. A recommended practical treatment algorithm to guide physicians in selecting the most appropriate anti-HER2 therapy for their patients is suggested. | - |
dc.language | eng | - |
dc.publisher | SAGE Publications (UK and US): Open Access Titles. The Journal's web site is located at https://journals.sagepub.com/home/tama | - |
dc.relation.ispartof | Therapeutic Advances in Medical Oncology | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | HER2+ breast cancer | - |
dc.subject | HER2-targeted therapy | - |
dc.subject | metastatic brain tumours | - |
dc.subject | radiotherapy | - |
dc.subject | tyrosine kinase inhibitor | - |
dc.title | Local and systemic treatment for HER2-positive breast cancer with brain metastases: a comprehensive review | - |
dc.type | Article | - |
dc.identifier.email | Chan, WL: winglok@hku.hk | - |
dc.identifier.email | Lam, TC: lamtc03@hku.hk | - |
dc.identifier.email | Lam, KO: lamkaon@hku.hk | - |
dc.identifier.email | Ngan, RKC: rkcngan@hku.hk | - |
dc.identifier.email | Kwong, D: dlwkwong@hku.hk | - |
dc.identifier.authority | Chan, WL=rp02541 | - |
dc.identifier.authority | Lam, TC=rp02128 | - |
dc.identifier.authority | Lam, KO=rp01501 | - |
dc.identifier.authority | Ngan, RKC=rp02371 | - |
dc.identifier.authority | Kwong, D=rp00414 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1177/1758835920953729 | - |
dc.identifier.scopus | eid_2-s2.0-85090976353 | - |
dc.identifier.hkuros | 317868 | - |
dc.identifier.hkuros | 314686 | - |
dc.identifier.hkuros | 314846 | - |
dc.identifier.hkuros | 314866 | - |
dc.identifier.volume | 12 | - |
dc.identifier.spage | 1 | - |
dc.identifier.epage | 14 | - |
dc.identifier.isi | WOS:000570708300001 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 1758-8340 | - |