File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Infection of dogs with SARS-CoV-2

TitleInfection of dogs with SARS-CoV-2
Authors
Issue Date2020
PublisherNature Research (part of Springer Nature). The Journal's web site is located at http://www.nature.com/nature
Citation
Nature, 2020, v. 586, p. 776-778 How to Cite?
AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first detected in Wuhan in December 2019 and caused coronavirus disease 2019 (COVID-19)1,2. In 2003, the closely related SARS-CoV had been detected in domestic cats and a dog3. However, little is known about the susceptibility of domestic pet mammals to SARS-CoV-2. Here, using PCR with reverse transcription, serology, sequencing the viral genome and virus isolation, we show that 2 out of 15 dogs from households with confirmed human cases of COVID-19 in Hong Kong were found to be infected with SARS-CoV-2. SARS-CoV-2 RNA was detected in five nasal swabs collected over a 13-day period from a 17-year-old neutered male Pomeranian. A 2.5-year-old male German shepherd was positive for SARS-CoV-2 RNA on two occasions and virus was isolated from nasal and oral swabs. Antibody responses were detected in both dogs using plaque-reduction-neutralization assays. Viral genetic sequences of viruses from the two dogs were identical to the virus detected in the respective human cases. The dogs remained asymptomatic during quarantine. The evidence suggests that these are instances of human-to-animal transmission of SARS-CoV-2. It is unclear whether infected dogs can transmit the virus to other animals or back to humans.
Persistent Identifierhttp://hdl.handle.net/10722/290815
ISSN
2020 Impact Factor: 49.962
2020 SCImago Journal Rankings: 15.993
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSit, THC-
dc.contributor.authorBrackman, CJ-
dc.contributor.authorIp, SM-
dc.contributor.authorTam, KWS-
dc.contributor.authorLaw, PYT-
dc.contributor.authorTo, EMW-
dc.contributor.authorYu, VYT-
dc.contributor.authorSims, LD-
dc.contributor.authorTsang, DNC-
dc.contributor.authorChu, DKW-
dc.contributor.authorPerera, RAPM-
dc.contributor.authorPoon, LLM-
dc.contributor.authorPeiris, M-
dc.date.accessioned2020-11-02T05:47:31Z-
dc.date.available2020-11-02T05:47:31Z-
dc.date.issued2020-
dc.identifier.citationNature, 2020, v. 586, p. 776-778-
dc.identifier.issn0028-0836-
dc.identifier.urihttp://hdl.handle.net/10722/290815-
dc.description.abstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first detected in Wuhan in December 2019 and caused coronavirus disease 2019 (COVID-19)1,2. In 2003, the closely related SARS-CoV had been detected in domestic cats and a dog3. However, little is known about the susceptibility of domestic pet mammals to SARS-CoV-2. Here, using PCR with reverse transcription, serology, sequencing the viral genome and virus isolation, we show that 2 out of 15 dogs from households with confirmed human cases of COVID-19 in Hong Kong were found to be infected with SARS-CoV-2. SARS-CoV-2 RNA was detected in five nasal swabs collected over a 13-day period from a 17-year-old neutered male Pomeranian. A 2.5-year-old male German shepherd was positive for SARS-CoV-2 RNA on two occasions and virus was isolated from nasal and oral swabs. Antibody responses were detected in both dogs using plaque-reduction-neutralization assays. Viral genetic sequences of viruses from the two dogs were identical to the virus detected in the respective human cases. The dogs remained asymptomatic during quarantine. The evidence suggests that these are instances of human-to-animal transmission of SARS-CoV-2. It is unclear whether infected dogs can transmit the virus to other animals or back to humans.-
dc.languageeng-
dc.publisherNature Research (part of Springer Nature). The Journal's web site is located at http://www.nature.com/nature-
dc.relation.ispartofNature-
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: https://doi.org/[insert DOI]-
dc.titleInfection of dogs with SARS-CoV-2-
dc.typeArticle-
dc.identifier.emailChu, DKW: dkwchu@hku.hk-
dc.identifier.emailPerera, RAPM: mahenp@hku.hk-
dc.identifier.emailPoon, LLM: llmpoon@hkucc.hku.hk-
dc.identifier.emailPeiris, M: malik@hkucc.hku.hk-
dc.identifier.authorityChu, DKW=rp02512-
dc.identifier.authorityPerera, RAPM=rp02500-
dc.identifier.authorityPoon, LLM=rp00484-
dc.identifier.authorityPeiris, M=rp00410-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1038/s41586-020-2334-5-
dc.identifier.pmid32408337-
dc.identifier.pmcidPMC7606701-
dc.identifier.scopuseid_2-s2.0-85084602001-
dc.identifier.hkuros317758-
dc.identifier.volume586-
dc.identifier.spage776-
dc.identifier.epage778-
dc.identifier.isiWOS:000554511200001-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl0028-0836-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats