File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: EBV renders B cells susceptible to HIV-1 in humanized mice

TitleEBV renders B cells susceptible to HIV-1 in humanized mice
Authors
Issue Date2020
PublisherLife Science Alliance LLC. The Journal's web site is located at https://www.life-science-alliance.org/
Citation
Life Science Alliance, 2020, v. 3 n. 8, p. article no. e202000640 How to Cite?
AbstractHIV and EBV are human pathogens that cause a considerable burden to worldwide health. In combination, these viruses are linked to AIDS-associated lymphomas. We found that EBV, which transforms B cells, renders them susceptible to HIV-1 infection in a CXCR4 and CD4-dependent manner in vitro and that CXCR4-tropic HIV-1 integrates into the genome of these B cells with the same molecular profile as in autologous CD4+ T cells. In addition, we established a humanized mouse model to investigate the in vivo interactions of EBV and HIV-1 upon coinfection. The respective mice that reconstitute human immune system components upon transplantation with CD34+ human hematopoietic progenitor cells could recapitulate aspects of EBV and HIV immunobiology observed in dual-infected patients. Upon coinfection of humanized mice, EBV/HIV dual-infected B cells could be detected, but were susceptible to CD8+ T-cell–mediated immune control.
Persistent Identifierhttp://hdl.handle.net/10722/290627
ISSN
2023 Impact Factor: 3.3
2023 SCImago Journal Rankings: 1.907
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMcHugh, D-
dc.contributor.authorMyburgh, R-
dc.contributor.authorCaduff, N-
dc.contributor.authorSpohn, M-
dc.contributor.authorKok, YL-
dc.contributor.authorKeller, CW-
dc.contributor.authorMurer, A-
dc.contributor.authorChatterjee, B-
dc.contributor.authorRühl, J-
dc.contributor.authorEngelmann, C-
dc.contributor.authorChijioke, O-
dc.contributor.authorQuast, I-
dc.contributor.authorShilaih, M-
dc.contributor.authorStrouvelle, VP-
dc.contributor.authorNeumann, K-
dc.contributor.authorMenter, T-
dc.contributor.authorDirnhofer, S-
dc.contributor.authorLam, JKP-
dc.contributor.authorHui, KF-
dc.contributor.authorBredl, S-
dc.contributor.authorSchlaepfer, E-
dc.contributor.authorSorce, S-
dc.contributor.authorZbinden, A-
dc.contributor.authorCapaul, R-
dc.contributor.authorLünemann, JD-
dc.contributor.authorAguzzi, A-
dc.contributor.authorChiang, AKS-
dc.contributor.authorKempf, W-
dc.contributor.authorTrkola, A-
dc.contributor.authorMetzner, KJ-
dc.contributor.authorManz, MG-
dc.contributor.authorGrundhoff, A-
dc.contributor.authorSpeck, RF-
dc.contributor.authorMünz, C-
dc.date.accessioned2020-11-02T05:44:53Z-
dc.date.available2020-11-02T05:44:53Z-
dc.date.issued2020-
dc.identifier.citationLife Science Alliance, 2020, v. 3 n. 8, p. article no. e202000640-
dc.identifier.issn2575-1077-
dc.identifier.urihttp://hdl.handle.net/10722/290627-
dc.description.abstractHIV and EBV are human pathogens that cause a considerable burden to worldwide health. In combination, these viruses are linked to AIDS-associated lymphomas. We found that EBV, which transforms B cells, renders them susceptible to HIV-1 infection in a CXCR4 and CD4-dependent manner in vitro and that CXCR4-tropic HIV-1 integrates into the genome of these B cells with the same molecular profile as in autologous CD4+ T cells. In addition, we established a humanized mouse model to investigate the in vivo interactions of EBV and HIV-1 upon coinfection. The respective mice that reconstitute human immune system components upon transplantation with CD34+ human hematopoietic progenitor cells could recapitulate aspects of EBV and HIV immunobiology observed in dual-infected patients. Upon coinfection of humanized mice, EBV/HIV dual-infected B cells could be detected, but were susceptible to CD8+ T-cell–mediated immune control.-
dc.languageeng-
dc.publisherLife Science Alliance LLC. The Journal's web site is located at https://www.life-science-alliance.org/-
dc.relation.ispartofLife Science Alliance-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleEBV renders B cells susceptible to HIV-1 in humanized mice-
dc.typeArticle-
dc.identifier.emailChiang, AKS: chiangak@hku.hk-
dc.identifier.authorityChiang, AKS=rp00403-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.26508/lsa.202000640-
dc.identifier.pmid32576602-
dc.identifier.pmcidPMC7335381-
dc.identifier.scopuseid_2-s2.0-85087015158-
dc.identifier.hkuros317754-
dc.identifier.volume3-
dc.identifier.issue8-
dc.identifier.spagearticle no. e202000640-
dc.identifier.epagearticle no. e202000640-
dc.identifier.isiWOS:000564798900001-
dc.publisher.placeUnited States-
dc.identifier.issnl2575-1077-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats