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- Publisher Website: 10.1016/j.bioactmat.2020.08.025
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- PMID: 32995676
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Article: Stepwise 3D-spatio-temporal magnesium cationic niche: Nanocomposite scaffold mediated microenvironment for modulating intramembranous ossification
Title | Stepwise 3D-spatio-temporal magnesium cationic niche: Nanocomposite scaffold mediated microenvironment for modulating intramembranous ossification |
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Authors | |
Keywords | Nanocomposite Magnesium ion Microenvironment 3D scaffold Bone tissue regeneration |
Issue Date | 2021 |
Publisher | Ke Ai Publishing Communications Ltd. The Journal's web site is located at http://www.sciencedirect.com/science/journal/2452199X |
Citation | Bioactive Materials, 2021, v. 6 n. 2, p. 503-519 How to Cite? |
Abstract | The fate of cells and subsequent bone regeneration is highly correlated with temporospatial coordination of chemical, biological, or physical cues within a local tissue microenvironment. Deeper understanding of how mammalian cells react to local tissue microenvironment is paramount important when designing next generation of biomaterials for tissue engineering. This study aims to investigate that the regulation of magnesium cationic (Mg2+) tissue microenvironment is able to convince early-stage bone regeneration and its mechanism undergoes intramembranous ossification. It was discovered that moderate Mg2+ content niche (~4.11 mM) led to superior bone regeneration, while Mg2+-free and strong Mg2+ content (~16.44 mM) discouraged cell adhesion, proliferation and osteogenic differentiation, thereby bone formation was rarely found. When magnesium ions diffused into free Mg zone from concentrated zone in late time point, new bone formation on free Mg zone became significant through intramembranous ossification. This study successfully demonstrates that magnesium cationic microenvironment serves as an effective biochemical cue and is able to modulate the process of bony tissue regeneration. The knowledge of how a Mg2+ cationic microenvironment intertwines with cells and subsequent bone formation gained from this study may provide a new insight to develop the next generation of tissue-repairing biomaterials. |
Persistent Identifier | http://hdl.handle.net/10722/290622 |
ISSN | 2023 Impact Factor: 18.0 2023 SCImago Journal Rankings: 3.466 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Shen, J | - |
dc.contributor.author | CHEN, B | - |
dc.contributor.author | Zhai, X | - |
dc.contributor.author | Qiao, W | - |
dc.contributor.author | Wu, S | - |
dc.contributor.author | Liu, X | - |
dc.contributor.author | Zhao, Y | - |
dc.contributor.author | Ruan, C | - |
dc.contributor.author | Pan, H | - |
dc.contributor.author | Chu, P | - |
dc.contributor.author | Cheung, KMC | - |
dc.contributor.author | Yeung, KWK | - |
dc.date.accessioned | 2020-11-02T05:44:49Z | - |
dc.date.available | 2020-11-02T05:44:49Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Bioactive Materials, 2021, v. 6 n. 2, p. 503-519 | - |
dc.identifier.issn | 2452-199X | - |
dc.identifier.uri | http://hdl.handle.net/10722/290622 | - |
dc.description.abstract | The fate of cells and subsequent bone regeneration is highly correlated with temporospatial coordination of chemical, biological, or physical cues within a local tissue microenvironment. Deeper understanding of how mammalian cells react to local tissue microenvironment is paramount important when designing next generation of biomaterials for tissue engineering. This study aims to investigate that the regulation of magnesium cationic (Mg2+) tissue microenvironment is able to convince early-stage bone regeneration and its mechanism undergoes intramembranous ossification. It was discovered that moderate Mg2+ content niche (~4.11 mM) led to superior bone regeneration, while Mg2+-free and strong Mg2+ content (~16.44 mM) discouraged cell adhesion, proliferation and osteogenic differentiation, thereby bone formation was rarely found. When magnesium ions diffused into free Mg zone from concentrated zone in late time point, new bone formation on free Mg zone became significant through intramembranous ossification. This study successfully demonstrates that magnesium cationic microenvironment serves as an effective biochemical cue and is able to modulate the process of bony tissue regeneration. The knowledge of how a Mg2+ cationic microenvironment intertwines with cells and subsequent bone formation gained from this study may provide a new insight to develop the next generation of tissue-repairing biomaterials. | - |
dc.language | eng | - |
dc.publisher | Ke Ai Publishing Communications Ltd. The Journal's web site is located at http://www.sciencedirect.com/science/journal/2452199X | - |
dc.relation.ispartof | Bioactive Materials | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Nanocomposite | - |
dc.subject | Magnesium ion | - |
dc.subject | Microenvironment | - |
dc.subject | 3D scaffold | - |
dc.subject | Bone tissue regeneration | - |
dc.title | Stepwise 3D-spatio-temporal magnesium cationic niche: Nanocomposite scaffold mediated microenvironment for modulating intramembranous ossification | - |
dc.type | Article | - |
dc.identifier.email | Shen, J: jieshen@hku.hk | - |
dc.identifier.email | Qiao, W: drqiao@hku.hk | - |
dc.identifier.email | Cheung, KMC: cheungmc@hku.hk | - |
dc.identifier.email | Yeung, KWK: wkkyeung@hku.hk | - |
dc.identifier.authority | Cheung, KMC=rp00387 | - |
dc.identifier.authority | Yeung, KWK=rp00309 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1016/j.bioactmat.2020.08.025 | - |
dc.identifier.pmid | 32995676 | - |
dc.identifier.pmcid | PMC7492774 | - |
dc.identifier.scopus | eid_2-s2.0-85090562707 | - |
dc.identifier.hkuros | 318183 | - |
dc.identifier.volume | 6 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 503 | - |
dc.identifier.epage | 519 | - |
dc.identifier.isi | WOS:000595346000016 | - |
dc.publisher.place | China | - |
dc.identifier.issnl | 2452-199X | - |