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Article: Electrochemical characteristics of microelectrode designed for electrical stimulation

TitleElectrochemical characteristics of microelectrode designed for electrical stimulation
Authors
KeywordsMicroelectrode array
Parylene-C
Electrochemical characteristics
Issue Date2019
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedical-engineering-online.com
Citation
BioMedical Engineering OnLine, 2019, v. 18 n. 1, p. article no. 86 How to Cite?
AbstractBackground: Microelectrode arrays play an important role in prosthetic implants for neural signal recording or applying electrical pulses stimulation to target nerve system. Safety and long-term reliability are essential requirements for microelectrode arrays applied in electrical stimulation. In design and fabrication of the microelectrode array, soft materials are generally chosen to be the substrate for the aim of achieving better compliance with the surrounding tissue while maintaining minimal damage. By flexing of the array to the surface, the array is capable of keeping a more stable electrical contact resulting in a significantly improved signal detected. Methods: In this study, we design and fabricate a flexible microelectrode array with gold as the electrode material and parylene-C as the substrate. The fabrication process of the array is presented. The in vitro electrochemical characteristics of the microelectrode are investigated by electrochemical impedance spectroscopy and cyclic voltammetry in a three-electrode electrochemical cell containing phosphate-buffered saline. Charge injection capacity measurements are carried out by multichannel systems and the CSC of the microarray is calculated. Results: Electrochemical results showed that impedance decreased with frequency. The average impedance of the Au electrodes at 1 kHz was 36.54 ± 0.88 kΩ. The average phase angle at 1 kHz was − 73.52 ± 1.3°, and the CIC of the microelectrode was 22.3 µC/cm2. The results demonstrated that the microelectrode array performed as expected for neuronal signal recording or stimulation. Conclusions: With parylene-C as the substrate, the microarray has good flexibility. The electrochemical characteristics’ results show that the array has the ability to resist any corrosion on metal–electrolyte interface and has good biocompatibility. This low-cost, flexible parylene-based, gold microelectrode array shows potential for use in implant neurological signal acquisition or neurostimulation applications.
Persistent Identifierhttp://hdl.handle.net/10722/290620
ISSN
2018 Impact Factor: 2.013
2015 SCImago Journal Rankings: 0.531
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCUI, H-
dc.contributor.authorXIE, X-
dc.contributor.authorXU, S-
dc.contributor.authorCHAN, LLH-
dc.contributor.authorHu, Y-
dc.date.accessioned2020-11-02T05:44:47Z-
dc.date.available2020-11-02T05:44:47Z-
dc.date.issued2019-
dc.identifier.citationBioMedical Engineering OnLine, 2019, v. 18 n. 1, p. article no. 86-
dc.identifier.issn1475-925X-
dc.identifier.urihttp://hdl.handle.net/10722/290620-
dc.description.abstractBackground: Microelectrode arrays play an important role in prosthetic implants for neural signal recording or applying electrical pulses stimulation to target nerve system. Safety and long-term reliability are essential requirements for microelectrode arrays applied in electrical stimulation. In design and fabrication of the microelectrode array, soft materials are generally chosen to be the substrate for the aim of achieving better compliance with the surrounding tissue while maintaining minimal damage. By flexing of the array to the surface, the array is capable of keeping a more stable electrical contact resulting in a significantly improved signal detected. Methods: In this study, we design and fabricate a flexible microelectrode array with gold as the electrode material and parylene-C as the substrate. The fabrication process of the array is presented. The in vitro electrochemical characteristics of the microelectrode are investigated by electrochemical impedance spectroscopy and cyclic voltammetry in a three-electrode electrochemical cell containing phosphate-buffered saline. Charge injection capacity measurements are carried out by multichannel systems and the CSC of the microarray is calculated. Results: Electrochemical results showed that impedance decreased with frequency. The average impedance of the Au electrodes at 1 kHz was 36.54 ± 0.88 kΩ. The average phase angle at 1 kHz was − 73.52 ± 1.3°, and the CIC of the microelectrode was 22.3 µC/cm2. The results demonstrated that the microelectrode array performed as expected for neuronal signal recording or stimulation. Conclusions: With parylene-C as the substrate, the microarray has good flexibility. The electrochemical characteristics’ results show that the array has the ability to resist any corrosion on metal–electrolyte interface and has good biocompatibility. This low-cost, flexible parylene-based, gold microelectrode array shows potential for use in implant neurological signal acquisition or neurostimulation applications.-
dc.languageeng-
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedical-engineering-online.com-
dc.relation.ispartofBioMedical Engineering OnLine-
dc.rightsBioMedical Engineering OnLine. Copyright © BioMed Central Ltd.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectMicroelectrode array-
dc.subjectParylene-C-
dc.subjectElectrochemical characteristics-
dc.titleElectrochemical characteristics of microelectrode designed for electrical stimulation-
dc.typeArticle-
dc.identifier.emailHu, Y: yhud@hku.hk-
dc.identifier.authorityHu, Y=rp00432-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/s12938-019-0704-8-
dc.identifier.pmid31370902-
dc.identifier.pmcidPMC6676582-
dc.identifier.scopuseid_2-s2.0-85071037982-
dc.identifier.hkuros317845-
dc.identifier.volume18-
dc.identifier.issue1-
dc.identifier.spagearticle no. 86-
dc.identifier.epagearticle no. 86-
dc.identifier.isiWOS:000478573500001-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl1475-925X-

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