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Article: Application of Acupuncture to Attenuate Immune Responses and Oxidative Stress in Postoperative Cognitive Dysfunction: What Do We Know So Far?

TitleApplication of Acupuncture to Attenuate Immune Responses and Oxidative Stress in Postoperative Cognitive Dysfunction: What Do We Know So Far?
Authors
KeywordsCellular events
Clinical practices
Cognitive impairment
Immune response
Neurological disorders
Issue Date2020
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/oximed/
Citation
Oxidative Medicine and Cellular Longevity, 2020, v. 2020, p. article no. 9641904 How to Cite?
AbstractPostoperative cognitive dysfunction (POCD) is a common sequela following surgery and hospitalization. The prevention and management of POCD are important during clinical practice. POCD more commonly affects elderly patients who have undergone major surgery and can result in major decline in quality of life for both patients and their families. Acupuncture has been suggested as an effective intervention for many neurological disorders. In recent years, there are increasing interest in the use of acupuncture to prevent and treat POCD. In this review, we summarized the clinical and preclinical evidence of acupuncture on POCD using a narrative approach and discussed the potential mechanisms involved. The experimental details and findings of studies were summarized in tables and analyzed. Most of the clinical studies suggested that acupuncture before surgery could reduce the incidence of POCD and reduce the levels of systematic inflammatory markers. However, their reliability is limited by methodological flaws. Animal studies showed that acupuncture reduced cognitive impairment and the associated pathology after various types of surgery. It is possible that acupuncture modulates inflammation, oxidative stress, synaptic changes, and other cellular events to mitigate POCD. In conclusion, acupuncture is a potential intervention for POCD. More clinical studies with good research design are required to confirm its effectiveness. At the same time, findings from animal studies will help reveal the protective mechanisms, in which systematic inflammation is likely to play a major role.
Persistent Identifierhttp://hdl.handle.net/10722/290060
ISSN
2021 Impact Factor: 7.310
2023 SCImago Journal Rankings: 1.477
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHo, YS-
dc.contributor.authorZhao, FY-
dc.contributor.authorYeung, WF-
dc.contributor.authorWong, GTC-
dc.contributor.authorZhang, HQ-
dc.contributor.authorChang, RCC-
dc.date.accessioned2020-10-22T08:21:31Z-
dc.date.available2020-10-22T08:21:31Z-
dc.date.issued2020-
dc.identifier.citationOxidative Medicine and Cellular Longevity, 2020, v. 2020, p. article no. 9641904-
dc.identifier.issn1942-0900-
dc.identifier.urihttp://hdl.handle.net/10722/290060-
dc.description.abstractPostoperative cognitive dysfunction (POCD) is a common sequela following surgery and hospitalization. The prevention and management of POCD are important during clinical practice. POCD more commonly affects elderly patients who have undergone major surgery and can result in major decline in quality of life for both patients and their families. Acupuncture has been suggested as an effective intervention for many neurological disorders. In recent years, there are increasing interest in the use of acupuncture to prevent and treat POCD. In this review, we summarized the clinical and preclinical evidence of acupuncture on POCD using a narrative approach and discussed the potential mechanisms involved. The experimental details and findings of studies were summarized in tables and analyzed. Most of the clinical studies suggested that acupuncture before surgery could reduce the incidence of POCD and reduce the levels of systematic inflammatory markers. However, their reliability is limited by methodological flaws. Animal studies showed that acupuncture reduced cognitive impairment and the associated pathology after various types of surgery. It is possible that acupuncture modulates inflammation, oxidative stress, synaptic changes, and other cellular events to mitigate POCD. In conclusion, acupuncture is a potential intervention for POCD. More clinical studies with good research design are required to confirm its effectiveness. At the same time, findings from animal studies will help reveal the protective mechanisms, in which systematic inflammation is likely to play a major role.-
dc.languageeng-
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/oximed/-
dc.relation.ispartofOxidative Medicine and Cellular Longevity-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectCellular events-
dc.subjectClinical practices-
dc.subjectCognitive impairment-
dc.subjectImmune response-
dc.subjectNeurological disorders-
dc.titleApplication of Acupuncture to Attenuate Immune Responses and Oxidative Stress in Postoperative Cognitive Dysfunction: What Do We Know So Far?-
dc.typeArticle-
dc.identifier.emailWong, GTC: gordon@hku.hk-
dc.identifier.emailChang, RCC: rccchang@hku.hk-
dc.identifier.authorityWong, GTC=rp00523-
dc.identifier.authorityChang, RCC=rp00470-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2020/9641904-
dc.identifier.pmid32148660-
dc.identifier.pmcidPMC7044481-
dc.identifier.scopuseid_2-s2.0-85080860707-
dc.identifier.hkuros317252-
dc.identifier.volume2020-
dc.identifier.spagearticle no. 9641904-
dc.identifier.epagearticle no. 9641904-
dc.identifier.isiWOS:000593890300001-
dc.publisher.placeUnited States-
dc.identifier.issnl1942-0994-

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