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- Publisher Website: 10.1038/s41467-018-06473-x
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- PMID: 30301893
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Article: Meta-analysis of effects of exclusive breastfeeding on infant gut microbiota across populations
Title | Meta-analysis of effects of exclusive breastfeeding on infant gut microbiota across populations |
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Authors | |
Keywords | biodiversity breast feeding diarrhea dysbiosis female |
Issue Date | 2018 |
Publisher | Nature Research (part of Springer Nature): Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html |
Citation | Nature Communications, 2018, v. 9 n. 1, p. article no. 4169 How to Cite? |
Abstract | Previous studies on the differences in gut microbiota between exclusively breastfed (EBF) and non-EBF infants have provided highly variable results. Here we perform a meta-analysis of seven microbiome studies (1825 stool samples from 684 infants) to compare the gut microbiota of non-EBF and EBF infants across populations. In the first 6 months of life, gut bacterial diversity, microbiota age, relative abundances of Bacteroidetes and Firmicutes, and predicted microbial pathways related to carbohydrate metabolism are consistently higher in non-EBF than in EBF infants, whereas relative abundances of pathways related to lipid metabolism, vitamin metabolism, and detoxification are lower. Variation in predicted microbial pathways associated with non-EBF infants is larger among infants born by Caesarian section than among those vaginally delivered. Longer duration of exclusive breastfeeding is associated with reduced diarrhea-related gut microbiota dysbiosis. Furthermore, differences in gut microbiota between EBF and non-EBF infants persist after 6 months of age. Our findings elucidate some mechanisms of short and long-term benefits of exclusive breastfeeding across different populations. |
Persistent Identifier | http://hdl.handle.net/10722/290014 |
ISSN | 2023 Impact Factor: 14.7 2023 SCImago Journal Rankings: 4.887 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ho, NT | - |
dc.contributor.author | Li, F | - |
dc.contributor.author | Lee-Sarwar, KA | - |
dc.contributor.author | Tun, HM | - |
dc.contributor.author | Brown, BP | - |
dc.contributor.author | Pannaraj, PS | - |
dc.contributor.author | Bender, JM | - |
dc.contributor.author | Azad, MB | - |
dc.contributor.author | Thompson, AL | - |
dc.contributor.author | Weiss, ST | - |
dc.contributor.author | Azcarate-Peril, MA | - |
dc.contributor.author | Litonjua, AA | - |
dc.contributor.author | Kozyrskyj, AL | - |
dc.contributor.author | Jaspan, HB | - |
dc.contributor.author | Aldrovandi, GM | - |
dc.contributor.author | Kuhn, L | - |
dc.date.accessioned | 2020-10-22T08:20:43Z | - |
dc.date.available | 2020-10-22T08:20:43Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Nature Communications, 2018, v. 9 n. 1, p. article no. 4169 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/10722/290014 | - |
dc.description.abstract | Previous studies on the differences in gut microbiota between exclusively breastfed (EBF) and non-EBF infants have provided highly variable results. Here we perform a meta-analysis of seven microbiome studies (1825 stool samples from 684 infants) to compare the gut microbiota of non-EBF and EBF infants across populations. In the first 6 months of life, gut bacterial diversity, microbiota age, relative abundances of Bacteroidetes and Firmicutes, and predicted microbial pathways related to carbohydrate metabolism are consistently higher in non-EBF than in EBF infants, whereas relative abundances of pathways related to lipid metabolism, vitamin metabolism, and detoxification are lower. Variation in predicted microbial pathways associated with non-EBF infants is larger among infants born by Caesarian section than among those vaginally delivered. Longer duration of exclusive breastfeeding is associated with reduced diarrhea-related gut microbiota dysbiosis. Furthermore, differences in gut microbiota between EBF and non-EBF infants persist after 6 months of age. Our findings elucidate some mechanisms of short and long-term benefits of exclusive breastfeeding across different populations. | - |
dc.language | eng | - |
dc.publisher | Nature Research (part of Springer Nature): Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html | - |
dc.relation.ispartof | Nature Communications | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | biodiversity | - |
dc.subject | breast feeding | - |
dc.subject | diarrhea | - |
dc.subject | dysbiosis | - |
dc.subject | female | - |
dc.title | Meta-analysis of effects of exclusive breastfeeding on infant gut microbiota across populations | - |
dc.type | Article | - |
dc.identifier.email | Tun, HM: heinmtun@hku.hk | - |
dc.identifier.authority | Tun, HM=rp02389 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1038/s41467-018-06473-x | - |
dc.identifier.pmid | 30301893 | - |
dc.identifier.pmcid | PMC6177445 | - |
dc.identifier.scopus | eid_2-s2.0-85054559204 | - |
dc.identifier.hkuros | 316825 | - |
dc.identifier.volume | 9 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | article no. 4169 | - |
dc.identifier.epage | article no. 4169 | - |
dc.identifier.isi | WOS:000446800200007 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 2041-1723 | - |