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Article: Different genetic barriers for resistance to HA stem antibodies in influenza H3 and H1 viruses

TitleDifferent genetic barriers for resistance to HA stem antibodies in influenza H3 and H1 viruses
Authors
Keywordsantigen binding
binding affinity
Influenza A virus (H1N1)
Influenza A virus (H3N2)
nonhuman
Issue Date2020
PublisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org
Citation
Science, 2020, v. 368 n. 6497, p. 1335-1340 How to Cite?
AbstractThe discovery and characterization of broadly neutralizing human antibodies (bnAbs) to the highly conserved stem region of influenza hemagglutinin (HA) have contributed to considerations of a universal influenza vaccine. However, the potential for resistance to stem bnAbs also needs to be more thoroughly evaluated. Using deep mutational scanning, with a focus on epitope residues, we found that the genetic barrier to resistance to stem bnAbs is low for the H3 subtype but substantially higher for the H1 subtype owing to structural differences in the HA stem. Several strong resistance mutations in H3 can be observed in naturally circulating strains and do not reduce in vitro viral fitness and in vivo pathogenicity. This study highlights a potential challenge for development of a truly universal influenza vaccine.
Persistent Identifierhttp://hdl.handle.net/10722/290008
ISSN
2023 Impact Factor: 44.7
2023 SCImago Journal Rankings: 11.902
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWu, NC-
dc.contributor.authorThompson, AJ-
dc.contributor.authorLee, JM-
dc.contributor.authorSu, W-
dc.contributor.authorArlian, BM-
dc.contributor.authorXie, J-
dc.contributor.authorLerner, RA-
dc.contributor.authorYen, HL-
dc.contributor.authorBloom, JD-
dc.contributor.authorWilson, IA-
dc.date.accessioned2020-10-22T08:20:37Z-
dc.date.available2020-10-22T08:20:37Z-
dc.date.issued2020-
dc.identifier.citationScience, 2020, v. 368 n. 6497, p. 1335-1340-
dc.identifier.issn0036-8075-
dc.identifier.urihttp://hdl.handle.net/10722/290008-
dc.description.abstractThe discovery and characterization of broadly neutralizing human antibodies (bnAbs) to the highly conserved stem region of influenza hemagglutinin (HA) have contributed to considerations of a universal influenza vaccine. However, the potential for resistance to stem bnAbs also needs to be more thoroughly evaluated. Using deep mutational scanning, with a focus on epitope residues, we found that the genetic barrier to resistance to stem bnAbs is low for the H3 subtype but substantially higher for the H1 subtype owing to structural differences in the HA stem. Several strong resistance mutations in H3 can be observed in naturally circulating strains and do not reduce in vitro viral fitness and in vivo pathogenicity. This study highlights a potential challenge for development of a truly universal influenza vaccine.-
dc.languageeng-
dc.publisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org-
dc.relation.ispartofScience-
dc.rightsScience. Copyright © American Association for the Advancement of Science.-
dc.rightsThis is the author’s version of the work. It is posted here by permission of the AAAS for personal use, not for redistribution. The definitive version was published in [Science Journal Title] on [Volume number and date], DOI: [insert DOI number].-
dc.subjectantigen binding-
dc.subjectbinding affinity-
dc.subjectInfluenza A virus (H1N1)-
dc.subjectInfluenza A virus (H3N2)-
dc.subjectnonhuman-
dc.titleDifferent genetic barriers for resistance to HA stem antibodies in influenza H3 and H1 viruses-
dc.typeArticle-
dc.identifier.emailSu, W: suwen@hku.hk-
dc.identifier.emailYen, HL: hyen@hku.hk-
dc.identifier.authorityYen, HL=rp00304-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1126/science.aaz5143-
dc.identifier.pmid32554590-
dc.identifier.pmcidPMC7412937-
dc.identifier.scopuseid_2-s2.0-85086692904-
dc.identifier.hkuros316543-
dc.identifier.volume368-
dc.identifier.issue6497-
dc.identifier.spage1335-
dc.identifier.epage1340-
dc.identifier.isiWOS:000544017600041-
dc.publisher.placeUnited States-
dc.identifier.issnl0036-8075-

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