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- Publisher Website: 10.1111/jan.14557
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- PMID: 33009836
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Article: The relative risk of developing type 2 diabetes among individuals with prediabetes compared with individuals with normoglycaemia: Meta‐analysis and meta‐regression
Title | The relative risk of developing type 2 diabetes among individuals with prediabetes compared with individuals with normoglycaemia: Meta‐analysis and meta‐regression 糖尿病前期个体与正常血糖个体相比患2型糖尿病的相对风险:荟萃分析和荟萃回归 |
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Authors | |
Keywords | diabetes mellitus meta-analysis meta-regression prediabetes relative risk |
Issue Date | 2020 |
Publisher | Wiley-Blackwell Publishing Ltd. The Journal's web site is located at http://www.journalofadvancednursing.com/ |
Citation | Journal of Advanced Nursing, 2020, v. 76 n. 12, p. 3329-3345 How to Cite? |
Abstract | Aims:
To assess the overall relative risk of diabetes in individuals with prediabetes based on updated diagnostic criteria, as compared with individuals with normoglycaemia; and to identify the study characteristics associated with the heterogeneity between studies.
Design:
Meta‐analysis, meta‐regression.
Data sources:
PubMed, CINAHL, British Nursing Index. Search time frame: December 1998–December 2018.
Review Methods:
The pooled relative risk of developing diabetes among individuals with prediabetes compared with those with normoglycaemia was calculated under a random effects model. Studies reported the natural progression from prediabetes to diabetes were included in this review. Sources of study heterogeneity were examined by a meta‐regression.
Results:
Fifty‐nine eligible studies were systematically identified. The pooled relative risk for diabetes among individuals with prediabetes as compared with normoglycaemia was 5.88 (95% CI: 5.02‐6.89). The annualized incidence rate (per 1,000 person‐year) for diabetes among individuals with prediabetes defined by different criteria varied from 2.20–212.15, with high heterogeneity between studies (I2 = 96.64%, Q test: p < .001). In the multivariable meta‐regression analysis, Asian population significantly increased RR compare to Caucasians. Besides, people with ‘elevated glycated haemoglobin A1c or impaired fasting glucose’ had highest relative risk compare to people with other types of prediabetes.
Conclusion:
Individuals with prediabetes had higher risk of developing diabetes than those with normoglycaemia. Races and diagnostic criteria of prediabetes were associated with the magnitude of the estimated risk.
Impact:
Prediabetes is a precursor of diabetes. To screen people with prediabetes as early as possible, practitioners could consider haemoglobin A1c test as an alternative to fasting plasma glucose test. Nurses should educate people especially Asians with prediabetes for the prevention of progression to diabetes. |
Persistent Identifier | http://hdl.handle.net/10722/289901 |
ISSN | 2023 Impact Factor: 3.8 2023 SCImago Journal Rankings: 1.218 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | XU, X | - |
dc.contributor.author | Leung, AYM | - |
dc.contributor.author | Smith, R | - |
dc.contributor.author | Wong, JYH | - |
dc.contributor.author | Chau, PH | - |
dc.contributor.author | Fong, DYT | - |
dc.date.accessioned | 2020-10-22T08:19:05Z | - |
dc.date.available | 2020-10-22T08:19:05Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Journal of Advanced Nursing, 2020, v. 76 n. 12, p. 3329-3345 | - |
dc.identifier.issn | 0309-2402 | - |
dc.identifier.uri | http://hdl.handle.net/10722/289901 | - |
dc.description.abstract | Aims: To assess the overall relative risk of diabetes in individuals with prediabetes based on updated diagnostic criteria, as compared with individuals with normoglycaemia; and to identify the study characteristics associated with the heterogeneity between studies. Design: Meta‐analysis, meta‐regression. Data sources: PubMed, CINAHL, British Nursing Index. Search time frame: December 1998–December 2018. Review Methods: The pooled relative risk of developing diabetes among individuals with prediabetes compared with those with normoglycaemia was calculated under a random effects model. Studies reported the natural progression from prediabetes to diabetes were included in this review. Sources of study heterogeneity were examined by a meta‐regression. Results: Fifty‐nine eligible studies were systematically identified. The pooled relative risk for diabetes among individuals with prediabetes as compared with normoglycaemia was 5.88 (95% CI: 5.02‐6.89). The annualized incidence rate (per 1,000 person‐year) for diabetes among individuals with prediabetes defined by different criteria varied from 2.20–212.15, with high heterogeneity between studies (I2 = 96.64%, Q test: p < .001). In the multivariable meta‐regression analysis, Asian population significantly increased RR compare to Caucasians. Besides, people with ‘elevated glycated haemoglobin A1c or impaired fasting glucose’ had highest relative risk compare to people with other types of prediabetes. Conclusion: Individuals with prediabetes had higher risk of developing diabetes than those with normoglycaemia. Races and diagnostic criteria of prediabetes were associated with the magnitude of the estimated risk. Impact: Prediabetes is a precursor of diabetes. To screen people with prediabetes as early as possible, practitioners could consider haemoglobin A1c test as an alternative to fasting plasma glucose test. Nurses should educate people especially Asians with prediabetes for the prevention of progression to diabetes. | - |
dc.language | eng | - |
dc.publisher | Wiley-Blackwell Publishing Ltd. The Journal's web site is located at http://www.journalofadvancednursing.com/ | - |
dc.relation.ispartof | Journal of Advanced Nursing | - |
dc.rights | Preprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Postprint This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | - |
dc.subject | diabetes mellitus | - |
dc.subject | meta-analysis | - |
dc.subject | meta-regression | - |
dc.subject | prediabetes | - |
dc.subject | relative risk | - |
dc.title | The relative risk of developing type 2 diabetes among individuals with prediabetes compared with individuals with normoglycaemia: Meta‐analysis and meta‐regression | - |
dc.title | 糖尿病前期个体与正常血糖个体相比患2型糖尿病的相对风险:荟萃分析和荟萃回归 | - |
dc.type | Article | - |
dc.identifier.email | Smith, R: robsmith@hku.hk | - |
dc.identifier.email | Wong, JYH: janetyh@hku.hk | - |
dc.identifier.email | Chau, PH: phpchau@hku.hk | - |
dc.identifier.email | Fong, DYT: dytfong@hku.hk | - |
dc.identifier.authority | Wong, JYH=rp01561 | - |
dc.identifier.authority | Chau, PH=rp00574 | - |
dc.identifier.authority | Fong, DYT=rp00253 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/jan.14557 | - |
dc.identifier.pmid | 33009836 | - |
dc.identifier.scopus | eid_2-s2.0-85091828761 | - |
dc.identifier.hkuros | 315968 | - |
dc.identifier.volume | 76 | - |
dc.identifier.issue | 12 | - |
dc.identifier.spage | 3329 | - |
dc.identifier.epage | 3345 | - |
dc.identifier.isi | WOS:000574627800001 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0309-2402 | - |