File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.15252/embj.201899727
- Scopus: eid_2-s2.0-85064513446
- PMID: 30979776
- WOS: WOS:000467961400004
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: YY1 regulates skeletal muscle regeneration through controlling metabolic reprogramming of satellite cells
Title | YY1 regulates skeletal muscle regeneration through controlling metabolic reprogramming of satellite cells |
---|---|
Authors | |
Keywords | Hif1α metabolic reprogramming muscle satellite cell skeletal muscle regeneration YY1 |
Issue Date | 2019 |
Publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/emboj/index.html |
Citation | The EMBO Journal, 2019, v. 38 n. 10, p. article no. e99727 How to Cite? |
Abstract | Skeletal muscle satellite cells (SCs) are adult muscle stem cells responsible for muscle regeneration after acute or chronic injuries. The lineage progression of quiescent SC toward activation, proliferation, and differentiation during the regeneration is orchestrated by cascades of transcription factors (TFs). Here, we elucidate the function of TF Yin Yang1 (YY1) in muscle regeneration. Muscle‐specific deletion of YY1 in embryonic muscle progenitors leads to severe deformity of diaphragm muscle formation, thus neonatal death. Inducible deletion of YY1 in SC almost completely blocks the acute damage‐induced muscle repair and exacerbates the chronic injury‐induced dystrophic phenotype. Examination of SC revealed that YY1 loss results in cell‐autonomous defect in activation and proliferation. Mechanistic search revealed that YY1 binds and represses mitochondrial gene expression. Simultaneously, it also stabilizes Hif1α protein and activates Hif1α‐mediated glycolytic genes to facilitate a metabolic reprogramming toward glycolysis which is needed for SC proliferation. Altogether, our findings have identified YY1 as a key regulator of SC metabolic reprogramming through its dual roles in modulating both mitochondrial and glycolytic pathways. |
Persistent Identifier | http://hdl.handle.net/10722/289846 |
ISSN | 2023 Impact Factor: 9.4 2023 SCImago Journal Rankings: 5.489 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chen, F | - |
dc.contributor.author | Zhou, J | - |
dc.contributor.author | Li, Y | - |
dc.contributor.author | Zhao, Y | - |
dc.contributor.author | Yuan, J | - |
dc.contributor.author | Cao, Y | - |
dc.contributor.author | Wang, L | - |
dc.contributor.author | Zhang, Z | - |
dc.contributor.author | Zhang, B | - |
dc.contributor.author | Wang, CC | - |
dc.contributor.author | Cheung, TH | - |
dc.contributor.author | Wu, Z | - |
dc.contributor.author | Wong, CCL | - |
dc.contributor.author | Sun, H | - |
dc.contributor.author | Wang, H | - |
dc.date.accessioned | 2020-10-22T08:18:18Z | - |
dc.date.available | 2020-10-22T08:18:18Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | The EMBO Journal, 2019, v. 38 n. 10, p. article no. e99727 | - |
dc.identifier.issn | 0261-4189 | - |
dc.identifier.uri | http://hdl.handle.net/10722/289846 | - |
dc.description.abstract | Skeletal muscle satellite cells (SCs) are adult muscle stem cells responsible for muscle regeneration after acute or chronic injuries. The lineage progression of quiescent SC toward activation, proliferation, and differentiation during the regeneration is orchestrated by cascades of transcription factors (TFs). Here, we elucidate the function of TF Yin Yang1 (YY1) in muscle regeneration. Muscle‐specific deletion of YY1 in embryonic muscle progenitors leads to severe deformity of diaphragm muscle formation, thus neonatal death. Inducible deletion of YY1 in SC almost completely blocks the acute damage‐induced muscle repair and exacerbates the chronic injury‐induced dystrophic phenotype. Examination of SC revealed that YY1 loss results in cell‐autonomous defect in activation and proliferation. Mechanistic search revealed that YY1 binds and represses mitochondrial gene expression. Simultaneously, it also stabilizes Hif1α protein and activates Hif1α‐mediated glycolytic genes to facilitate a metabolic reprogramming toward glycolysis which is needed for SC proliferation. Altogether, our findings have identified YY1 as a key regulator of SC metabolic reprogramming through its dual roles in modulating both mitochondrial and glycolytic pathways. | - |
dc.language | eng | - |
dc.publisher | Nature Publishing Group. The Journal's web site is located at http://www.nature.com/emboj/index.html | - |
dc.relation.ispartof | The EMBO Journal | - |
dc.rights | This is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: https://doi.org/[insert DOI] | - |
dc.subject | Hif1α | - |
dc.subject | metabolic reprogramming | - |
dc.subject | muscle satellite cell | - |
dc.subject | skeletal muscle regeneration | - |
dc.subject | YY1 | - |
dc.title | YY1 regulates skeletal muscle regeneration through controlling metabolic reprogramming of satellite cells | - |
dc.type | Article | - |
dc.identifier.email | Wong, CCL: carmencl@pathology.hku.hk | - |
dc.identifier.authority | Wong, CCL=rp01602 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.15252/embj.201899727 | - |
dc.identifier.pmid | 30979776 | - |
dc.identifier.pmcid | PMC6518041 | - |
dc.identifier.scopus | eid_2-s2.0-85064513446 | - |
dc.identifier.hkuros | 316588 | - |
dc.identifier.volume | 38 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | article no. e99727 | - |
dc.identifier.epage | article no. e99727 | - |
dc.identifier.isi | WOS:000467961400004 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0261-4189 | - |