File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Case of 'relapsing' COVID‐19 in a kidney transplant recipient

TitleCase of 'relapsing' COVID‐19 in a kidney transplant recipient
Authors
Keywordsacute kidney injury
COVID‐19
kidney transplantation
lopinavir‐ritonavir
SARS‐CoV‐2
Issue Date2020
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1440-1797
Citation
Nephrology, 2020, v. 25 n. 12, p. 933-936 How to Cite?
AbstractClinical outcomes of COVID‐19 vary considerably between patients. Little was known about the clinical course and optimal management of immunosuppressed patients infected with SARS‐CoV‐2. We report a kidney transplant recipient with COVID‐19 who presented with pneumonitis and acute kidney injury (AKI). She improved after reduction of immunosuppressive treatment and had two consecutive negative reverse transcription polymerase chain reaction (RT‐PCR) tests. Her respiratory tract samples turned positive again afterwards, and she was treated with lopinavir‐ritonavir. She had satisfactory virological and clinical response after a prolonged disease course. This case illustrates the risk of relapse or persisting shedding of SARS‐CoV‐2 in immunosuppressed patients, the important role of viral load monitoring in management, the challenges in balancing the risks of COVID‐19 progression and transplant rejection, and the pharmacokinetic interaction between immunosuppressive and antiviral medications.
Persistent Identifierhttp://hdl.handle.net/10722/289766
ISSN
2023 Impact Factor: 2.4
2023 SCImago Journal Rankings: 0.641
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMa, BM-
dc.contributor.authorHung, IFN-
dc.contributor.authorChan, GCW-
dc.contributor.authorTam, AR-
dc.contributor.authorChan, SSK-
dc.contributor.authorWong, BCK-
dc.contributor.authorFukuda, K-
dc.contributor.authorOhno, T-
dc.contributor.authorYuen, KY-
dc.contributor.authorChan, TM-
dc.date.accessioned2020-10-22T08:17:10Z-
dc.date.available2020-10-22T08:17:10Z-
dc.date.issued2020-
dc.identifier.citationNephrology, 2020, v. 25 n. 12, p. 933-936-
dc.identifier.issn1320-5358-
dc.identifier.urihttp://hdl.handle.net/10722/289766-
dc.description.abstractClinical outcomes of COVID‐19 vary considerably between patients. Little was known about the clinical course and optimal management of immunosuppressed patients infected with SARS‐CoV‐2. We report a kidney transplant recipient with COVID‐19 who presented with pneumonitis and acute kidney injury (AKI). She improved after reduction of immunosuppressive treatment and had two consecutive negative reverse transcription polymerase chain reaction (RT‐PCR) tests. Her respiratory tract samples turned positive again afterwards, and she was treated with lopinavir‐ritonavir. She had satisfactory virological and clinical response after a prolonged disease course. This case illustrates the risk of relapse or persisting shedding of SARS‐CoV‐2 in immunosuppressed patients, the important role of viral load monitoring in management, the challenges in balancing the risks of COVID‐19 progression and transplant rejection, and the pharmacokinetic interaction between immunosuppressive and antiviral medications.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1440-1797-
dc.relation.ispartofNephrology-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Postprint This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectacute kidney injury-
dc.subjectCOVID‐19-
dc.subjectkidney transplantation-
dc.subjectlopinavir‐ritonavir-
dc.subjectSARS‐CoV‐2-
dc.titleCase of 'relapsing' COVID‐19 in a kidney transplant recipient-
dc.typeArticle-
dc.identifier.emailHung, IFN: ivanhung@hkucc.hku.hk-
dc.identifier.emailChan, GCW: gcwchan1@hku.hk-
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hk-
dc.identifier.emailChan, TM: dtmchan@hkucc.hku.hk-
dc.identifier.authorityHung, IFN=rp00508-
dc.identifier.authorityYuen, KY=rp00366-
dc.identifier.authorityChan, TM=rp00394-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/nep.13786-
dc.identifier.pmid32951300-
dc.identifier.pmcidPMC7536982-
dc.identifier.scopuseid_2-s2.0-85091603854-
dc.identifier.hkuros315871-
dc.identifier.volume25-
dc.identifier.issue12-
dc.identifier.spage933-
dc.identifier.epage936-
dc.identifier.isiWOS:000573184700001-
dc.publisher.placeAustralia-
dc.identifier.issnl1320-5358-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats