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- Publisher Website: 10.1155/2019/1271492
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- PMID: 31662968
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Article: Effect of Periapical Diseases in Development of MRONJ in Immunocompromised Mouse Model
Title | Effect of Periapical Diseases in Development of MRONJ in Immunocompromised Mouse Model |
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Authors | |
Keywords | alveolar bone loss animal cell animal experiment animal model animal tissue |
Issue Date | 2019 |
Publisher | Hindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jbb/index.html |
Citation | BioMed Research International, 2019, v. 2019, p. article no. 1271492 How to Cite? |
Abstract | Objectives. This study aimed to assess the effect of zoledronic acid on an immunocompromised mice model with periapical disease. Materials and Methods. Thirty C57BL/6N mice were randomly divided into three groups (N = 10). All animals were subjected to bilateral ovariectomy (OVX) and then treated with saline (Veh), zoledronic acid (ZA), or concomitant zoledronic acid and dexamethasone (ZA/Dx) for 12 weeks. Eight weeks after starting drug administration, pulpal exposure was conducted on the lower left first molar. Four weeks after pulpal exposure, all mice were sacrificed and the mandibles were collected for radiological and histological examinations. Results. Microcomputed tomography (μ-CT) examination showed significantly reduced periapical bone resorption in the ZA/Dx group and decreased periodontal bone resorption in both ZA and ZA/Dx groups. Higher bone mineral density (BMD) and strengthened microstructure were found in ZA and ZA/Dx groups. More empty lacunae were found in ZA and ZA/Dx groups. Conclusions. Apical periodontitis aggravates MRONJ under immunocompromised circumstances. Concurrent use of ZA and steroids inhibits alveolar bone resorption but increases the risk of developing MRONJ. |
Persistent Identifier | http://hdl.handle.net/10722/289646 |
ISSN | 2023 Impact Factor: 2.6 2023 SCImago Journal Rankings: 0.656 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Rao, NJ | - |
dc.contributor.author | Yu, RQ | - |
dc.contributor.author | Wang, JY | - |
dc.contributor.author | Helm, A | - |
dc.contributor.author | Zheng, LW | - |
dc.date.accessioned | 2020-10-22T08:15:29Z | - |
dc.date.available | 2020-10-22T08:15:29Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | BioMed Research International, 2019, v. 2019, p. article no. 1271492 | - |
dc.identifier.issn | 2314-6133 | - |
dc.identifier.uri | http://hdl.handle.net/10722/289646 | - |
dc.description.abstract | Objectives. This study aimed to assess the effect of zoledronic acid on an immunocompromised mice model with periapical disease. Materials and Methods. Thirty C57BL/6N mice were randomly divided into three groups (N = 10). All animals were subjected to bilateral ovariectomy (OVX) and then treated with saline (Veh), zoledronic acid (ZA), or concomitant zoledronic acid and dexamethasone (ZA/Dx) for 12 weeks. Eight weeks after starting drug administration, pulpal exposure was conducted on the lower left first molar. Four weeks after pulpal exposure, all mice were sacrificed and the mandibles were collected for radiological and histological examinations. Results. Microcomputed tomography (μ-CT) examination showed significantly reduced periapical bone resorption in the ZA/Dx group and decreased periodontal bone resorption in both ZA and ZA/Dx groups. Higher bone mineral density (BMD) and strengthened microstructure were found in ZA and ZA/Dx groups. More empty lacunae were found in ZA and ZA/Dx groups. Conclusions. Apical periodontitis aggravates MRONJ under immunocompromised circumstances. Concurrent use of ZA and steroids inhibits alveolar bone resorption but increases the risk of developing MRONJ. | - |
dc.language | eng | - |
dc.publisher | Hindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jbb/index.html | - |
dc.relation.ispartof | BioMed Research International | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | alveolar bone loss | - |
dc.subject | animal cell | - |
dc.subject | animal experiment | - |
dc.subject | animal model | - |
dc.subject | animal tissue | - |
dc.title | Effect of Periapical Diseases in Development of MRONJ in Immunocompromised Mouse Model | - |
dc.type | Article | - |
dc.identifier.email | Zheng, LW: lwzheng@hkucc.hku.hk | - |
dc.identifier.authority | Zheng, LW=rp01411 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1155/2019/1271492 | - |
dc.identifier.pmid | 31662968 | - |
dc.identifier.pmcid | PMC6778953 | - |
dc.identifier.scopus | eid_2-s2.0-85073164438 | - |
dc.identifier.hkuros | 317150 | - |
dc.identifier.volume | 2019 | - |
dc.identifier.spage | article no. 1271492 | - |
dc.identifier.epage | article no. 1271492 | - |
dc.identifier.isi | WOS:000492942300002 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 2314-6133 | - |