File Download
Links for fulltext
(May Require Subscription)
- Scopus: eid_2-s2.0-85075512298
- PMID: 31761764
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: DNA sequence patterns in human major histocompatibility complex region in southern Chinese
Title | DNA sequence patterns in human major histocompatibility complex region in southern Chinese |
---|---|
Authors | |
Issue Date | 2019 |
Publisher | Hong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/ |
Citation | Hong Kong Medical Journal, 2019, v. 25 n. 5, suppl. 7, p. 13-16 How to Cite? |
Abstract | 1. We developed a programme, quantLD, for genome-wide comparisons of linkage disequilibrium difference between two populations and applied the methods to the major histocompatibility complex region in 1000 Genomes Project phase 3 data. Results suggested that linkage disequilibrium difference exists across populations.
2. We also developed a programme PyHLA for HLA alleles association analysis and applied to a set of 246 APOE ε4 allele negative Alzheimer disease cases and 172 normal controls. HLA-DRB1*07:01 and HLA-C*03 were inversely associated with Alzheimer disease, whereas HLA-DQB1*03:01 and DRB1*09:21 were associated with Alzheimer disease. |
Persistent Identifier | http://hdl.handle.net/10722/289583 |
ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 0.261 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, YQ | - |
dc.contributor.author | Sham, PS | - |
dc.contributor.author | Yip, SP | - |
dc.contributor.author | Fan, YH | - |
dc.contributor.author | Bao, SY | - |
dc.date.accessioned | 2020-10-22T08:14:40Z | - |
dc.date.available | 2020-10-22T08:14:40Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Hong Kong Medical Journal, 2019, v. 25 n. 5, suppl. 7, p. 13-16 | - |
dc.identifier.issn | 1024-2708 | - |
dc.identifier.uri | http://hdl.handle.net/10722/289583 | - |
dc.description.abstract | 1. We developed a programme, quantLD, for genome-wide comparisons of linkage disequilibrium difference between two populations and applied the methods to the major histocompatibility complex region in 1000 Genomes Project phase 3 data. Results suggested that linkage disequilibrium difference exists across populations. 2. We also developed a programme PyHLA for HLA alleles association analysis and applied to a set of 246 APOE ε4 allele negative Alzheimer disease cases and 172 normal controls. HLA-DRB1*07:01 and HLA-C*03 were inversely associated with Alzheimer disease, whereas HLA-DQB1*03:01 and DRB1*09:21 were associated with Alzheimer disease. | - |
dc.language | eng | - |
dc.publisher | Hong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/ | - |
dc.relation.ispartof | Hong Kong Medical Journal | - |
dc.title | DNA sequence patterns in human major histocompatibility complex region in southern Chinese | - |
dc.type | Article | - |
dc.identifier.email | Song, YQ: songy@hku.hk | - |
dc.identifier.email | Sham, PS: pcsham@hku.hk | - |
dc.identifier.authority | Song, YQ=rp00488 | - |
dc.identifier.authority | Sham, PS=rp00459 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.pmid | 31761764 | - |
dc.identifier.scopus | eid_2-s2.0-85075512298 | - |
dc.identifier.hkuros | 316018 | - |
dc.identifier.volume | 25 | - |
dc.identifier.issue | 5, suppl. 7 | - |
dc.identifier.spage | 13 | - |
dc.identifier.epage | 16 | - |
dc.publisher.place | Hong Kong | - |