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- Publisher Website: 10.1002/adbi.201900169
- Scopus: eid_2-s2.0-85076362307
- PMID: 32293123
- WOS: WOS:000506824900001
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Article: Unraveling Framework Nucleic Acid–Skin Cell Interactions with a Co‐Culture System
Title | Unraveling Framework Nucleic Acid–Skin Cell Interactions with a Co‐Culture System |
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Authors | |
Keywords | co‐culture system fibroblast framework nucleic acid keratinocyte transdermal drug delivery |
Issue Date | 2020 |
Publisher | Wiley - VCH Verlag GmbH & Co. KGaA. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2366-7478 |
Citation | Advanced Biosystems, 2020, v. 4 n. 1, p. article no. 1900169 How to Cite? |
Abstract | Framework nucleic acid (FNA) is an emerging drug carrier platform, with its biodegradability and uniform, tunable structures. Recently, its applicability in transdermal drug delivery has been demonstrated, extending the range of applications that are predominantly based on intravenous injection. However, FNA's interaction and impact toward the skin cells are yet to be elucidated. This study employs an optically clear keratinocyte/fibroblast co‐culture system to visualize the FNA–skin cell interactions. FNA's influence on these cells is evaluated through polymerase chain reaction analyses and metabolism assays. A size‐dependent interaction and cellular internalization on both keratinocytes and fibroblasts is observed, with no adverse effects on cell viability and functions. |
Persistent Identifier | http://hdl.handle.net/10722/289368 |
ISSN | 2022 Impact Factor: 4.1 2020 SCImago Journal Rankings: 1.153 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wiraja, C | - |
dc.contributor.author | Siantoputri, ME | - |
dc.contributor.author | LIU, S | - |
dc.contributor.author | Shum, HC | - |
dc.contributor.author | Xu, C | - |
dc.date.accessioned | 2020-10-22T08:11:39Z | - |
dc.date.available | 2020-10-22T08:11:39Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Advanced Biosystems, 2020, v. 4 n. 1, p. article no. 1900169 | - |
dc.identifier.issn | 2366-7478 | - |
dc.identifier.uri | http://hdl.handle.net/10722/289368 | - |
dc.description.abstract | Framework nucleic acid (FNA) is an emerging drug carrier platform, with its biodegradability and uniform, tunable structures. Recently, its applicability in transdermal drug delivery has been demonstrated, extending the range of applications that are predominantly based on intravenous injection. However, FNA's interaction and impact toward the skin cells are yet to be elucidated. This study employs an optically clear keratinocyte/fibroblast co‐culture system to visualize the FNA–skin cell interactions. FNA's influence on these cells is evaluated through polymerase chain reaction analyses and metabolism assays. A size‐dependent interaction and cellular internalization on both keratinocytes and fibroblasts is observed, with no adverse effects on cell viability and functions. | - |
dc.language | eng | - |
dc.publisher | Wiley - VCH Verlag GmbH & Co. KGaA. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2366-7478 | - |
dc.relation.ispartof | Advanced Biosystems | - |
dc.rights | This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | - |
dc.subject | co‐culture system | - |
dc.subject | fibroblast | - |
dc.subject | framework nucleic acid | - |
dc.subject | keratinocyte | - |
dc.subject | transdermal drug delivery | - |
dc.title | Unraveling Framework Nucleic Acid–Skin Cell Interactions with a Co‐Culture System | - |
dc.type | Article | - |
dc.identifier.email | Shum, HC: ashum@hku.hk | - |
dc.identifier.authority | Shum, HC=rp01439 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/adbi.201900169 | - |
dc.identifier.pmid | 32293123 | - |
dc.identifier.scopus | eid_2-s2.0-85076362307 | - |
dc.identifier.hkuros | 317475 | - |
dc.identifier.volume | 4 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | article no. 1900169 | - |
dc.identifier.epage | article no. 1900169 | - |
dc.identifier.isi | WOS:000506824900001 | - |
dc.publisher.place | Germany | - |
dc.identifier.issnl | 2366-7478 | - |