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Article: Characterizing Emerging Canine H3 Influenza Viruses

TitleCharacterizing Emerging Canine H3 Influenza Viruses
Authors
Editors
Editor(s):Lopez, CB
Keywordsairway epithelium cell
animal cell
animal experiment
animal model
antiviral susceptibility
Issue Date2020
PublisherPublic Library of Science. The Journal's web site is located at http://pathogens.plosjournals.org/perlserv/?request=index-html&issn=1553-7374
Citation
PLoS Pathogens, 2020, v. 16 n. 4, p. article no. e1008409 How to Cite?
AbstractThe continual emergence of novel influenza A strains from non-human hosts requires constant vigilance and the need for ongoing research to identify strains that may pose a human public health risk. Since 1999, canine H3 influenza A viruses (CIVs) have caused many thousands or millions of respiratory infections in dogs in the United States. While no human infections with CIVs have been reported to date, these viruses could pose a zoonotic risk. In these studies, the National Institutes of Allergy and Infectious Diseases (NIAID) Centers of Excellence for Influenza Research and Surveillance (CEIRS) network collaboratively demonstrated that CIVs replicated in some primary human cells and transmitted effectively in mammalian models. While people born after 1970 had little or no pre-existing humoral immunity against CIVs, the viruses were sensitive to existing antivirals and we identified a panel of H3 cross-reactive human monoclonal antibodies (hmAbs) that could have prophylactic and/or therapeutic value. Our data predict these CIVs posed a low risk to humans. Importantly, we showed that the CEIRS network could work together to provide basic research information important for characterizing emerging influenza viruses, although there were valuable lessons learned.
Persistent Identifierhttp://hdl.handle.net/10722/289244
ISSN
2020 Impact Factor: 6.823
2020 SCImago Journal Rankings: 3.719
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMartinez-Sobrido, L-
dc.contributor.authorBlanco-Lobo, P-
dc.contributor.authorRodriguez, L-
dc.contributor.authorFitzgerald, T-
dc.contributor.authorZhang, H-
dc.contributor.authorNguyen, P-
dc.contributor.authorAnderson, CS-
dc.contributor.authorHolden-Wiltse, J-
dc.contributor.authorBandyopadhyay, S-
dc.contributor.authorNogales, A-
dc.contributor.authorDeDiego, ML-
dc.contributor.authorWasik, BR-
dc.contributor.authorMiller, BL-
dc.contributor.authorHenry, C-
dc.contributor.authorWilson, PC-
dc.contributor.authorSangster, MY-
dc.contributor.authorTreanor, JJ-
dc.contributor.authorTopham, DJ-
dc.contributor.authorByrd-Leotis, L-
dc.contributor.authorSteinhauer, DA-
dc.contributor.authorCummings, RD-
dc.contributor.authorLuczo, JM-
dc.contributor.authorTompkins, SM-
dc.contributor.authorSakamoto, K-
dc.contributor.authorJones, CA-
dc.contributor.authorSteel, J-
dc.contributor.authorLowen, AC-
dc.contributor.authorDanzy, S-
dc.contributor.authorTao, H-
dc.contributor.authorFink, AL-
dc.contributor.authorKlein, SL-
dc.contributor.authorWohlgemuth, N-
dc.contributor.authorFenstermacher, KJ-
dc.contributor.authorel Najjar, F-
dc.contributor.authorPekosz, A-
dc.contributor.authorSauer, L-
dc.contributor.authorLewis, MK-
dc.contributor.authorShaw-Saliba, K-
dc.contributor.authorRothman, RE-
dc.contributor.authorLiu, ZY-
dc.contributor.authorChen, KF-
dc.contributor.authorParrish, CR-
dc.contributor.authorVoorhees, IEH-
dc.contributor.authorKawaoka, Y-
dc.contributor.authorNeumann, G-
dc.contributor.authorChiba, S-
dc.contributor.authorFan, S-
dc.contributor.authorHatta, M-
dc.contributor.authorKong, H-
dc.contributor.authorZhong, G-
dc.contributor.authorWang, G-
dc.contributor.authorUccellini, MB-
dc.contributor.authorGarcía-Sastre, A-
dc.contributor.authorPerez, DR-
dc.contributor.authorFerreri, LM-
dc.contributor.authorHerfst, S-
dc.contributor.authorRichard, M-
dc.contributor.authorFouchier, R-
dc.contributor.authorBurke, D-
dc.contributor.authorPattinson, D-
dc.contributor.authorSmith, DJ-
dc.contributor.authorMeliopoulos, V-
dc.contributor.authorFreiden, P-
dc.contributor.authorLivingston, B-
dc.contributor.authorSharp, B-
dc.contributor.authorCherry, S-
dc.contributor.authorDib, JC-
dc.contributor.authorYang, G-
dc.contributor.authorRussell, CJ-
dc.contributor.authorBarman, S-
dc.contributor.authorWebby, RJ-
dc.contributor.authorKrauss, S-
dc.contributor.authorDanner, A-
dc.contributor.authorWoodard, K-
dc.contributor.authorPeiris, M-
dc.contributor.authorPerera, RAPM-
dc.contributor.authorChan, MCW-
dc.contributor.authorGovorkova, EA-
dc.contributor.authorMarathe, BM-
dc.contributor.authorPascua, PNQ-
dc.contributor.authorSmith, G-
dc.contributor.authorLi, YT-
dc.contributor.authorThomas, PG-
dc.contributor.authorSchultz-Cherry, S-
dc.contributor.editorLopez, CB-
dc.date.accessioned2020-10-22T08:09:55Z-
dc.date.available2020-10-22T08:09:55Z-
dc.date.issued2020-
dc.identifier.citationPLoS Pathogens, 2020, v. 16 n. 4, p. article no. e1008409-
dc.identifier.issn1553-7366-
dc.identifier.urihttp://hdl.handle.net/10722/289244-
dc.description.abstractThe continual emergence of novel influenza A strains from non-human hosts requires constant vigilance and the need for ongoing research to identify strains that may pose a human public health risk. Since 1999, canine H3 influenza A viruses (CIVs) have caused many thousands or millions of respiratory infections in dogs in the United States. While no human infections with CIVs have been reported to date, these viruses could pose a zoonotic risk. In these studies, the National Institutes of Allergy and Infectious Diseases (NIAID) Centers of Excellence for Influenza Research and Surveillance (CEIRS) network collaboratively demonstrated that CIVs replicated in some primary human cells and transmitted effectively in mammalian models. While people born after 1970 had little or no pre-existing humoral immunity against CIVs, the viruses were sensitive to existing antivirals and we identified a panel of H3 cross-reactive human monoclonal antibodies (hmAbs) that could have prophylactic and/or therapeutic value. Our data predict these CIVs posed a low risk to humans. Importantly, we showed that the CEIRS network could work together to provide basic research information important for characterizing emerging influenza viruses, although there were valuable lessons learned.-
dc.languageeng-
dc.publisherPublic Library of Science. The Journal's web site is located at http://pathogens.plosjournals.org/perlserv/?request=index-html&issn=1553-7374-
dc.relation.ispartofPLoS Pathogens-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectairway epithelium cell-
dc.subjectanimal cell-
dc.subjectanimal experiment-
dc.subjectanimal model-
dc.subjectantiviral susceptibility-
dc.titleCharacterizing Emerging Canine H3 Influenza Viruses-
dc.typeArticle-
dc.identifier.emailPeiris, M: malik@hkucc.hku.hk-
dc.identifier.emailPerera, RAPM: mahenp@hku.hk-
dc.identifier.emailChan, MCW: mchan@hku.hk-
dc.identifier.authorityPeiris, M=rp00410-
dc.identifier.authorityPerera, RAPM=rp02500-
dc.identifier.authorityChan, MCW=rp00420-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.ppat.1008409-
dc.identifier.pmid32287326-
dc.identifier.pmcidPMC7182277-
dc.identifier.scopuseid_2-s2.0-85084104244-
dc.identifier.hkuros317030-
dc.identifier.volume16-
dc.identifier.issue4-
dc.identifier.spagearticle no. e1008409-
dc.identifier.epagearticle no. e1008409-
dc.identifier.isiWOS:000531365400058-
dc.publisher.placeUnited States-
dc.identifier.issnl1553-7366-

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