File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1152/ajpregu.00012.2017
- Scopus: eid_2-s2.0-85020215636
- PMID: 28381454
- WOS: WOS:000404379200005
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Erythropoiesis with endurance training: Dynamics and mechanisms
Title | Erythropoiesis with endurance training: Dynamics and mechanisms |
---|---|
Authors | |
Keywords | Erythropoietin Exercise training Plasma volume Red blood cell volume |
Issue Date | 2017 |
Citation | American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 2017, v. 312, n. 6, p. R894-R902 How to Cite? |
Abstract | © 2017 the American Physiological Society. The purpose of the present study was to characterize the progression of red blood cell volume (RBCV) expansion and potential volumetric and endocrine regulators of erythropoiesis during endurance training (ET). Nine healthy, untrained volunteers (age = 27 ± 4 yr) underwent supervised ET consisting of 3–4 × 60 min cycle ergometry sessions per week for 8 wk. Plasma volume (PV), RBCV, and overnight fasting hematological markers were determined before and at weeks 2, 4, and 8 of ET. In addition, plasma erythropoietin (EPO), cortisol, copeptin, and proatrial natriuretic peptide concentrations were measured during a 3-h morning period at baseline and postexercise at weeks 1 and 8. PV increased from baseline (2,405 ± 335 ml) at weeks 2, 4, and 8 (+374 ± 194, +505 ± 156, and +341 ± 160 ml, respectively, P 0.001). Increases in RBCV from baseline (1,737 ± 442 ml) were manifested at week 4 (+109 ± 114 ml, P = 0.030) and week 8 (+205 ± 109 ml, P = 0.001). Overnight fasting plasma EPO concentration increased from baseline (11.3 ± 4.8 mIU/ml) at week 2 (+2.5 ± 2.8 mIU·ml-1, P = 0.027) and returned to baseline concentration at weeks 4 and 8. Higher 3-h-postexercise EPO concentration was observed at week 1 (11.6 mIU/ml) compared with week 8 (8.4 ± 3.9 mIU/ml, P = 0.009) and baseline (9.0 ± 4.2 mIU/ml, P 0.019). Linear relationships between EPO concentration and hematocrit (β-56.2, P 0.001) and cortisol (β = 0.037, P 0.001) were detected throughout the ET intervention. In conclusion, ET leads to mild, transient increases in circulating EPO concentration, concurring with early PV expansion and lowered hematocrit, preceding gradual RBCV enhancement. |
Persistent Identifier | http://hdl.handle.net/10722/288858 |
ISSN | 2023 Impact Factor: 2.2 2023 SCImago Journal Rankings: 0.904 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Montero, David | - |
dc.contributor.author | Breenfeldt-Andersen, Andreas | - |
dc.contributor.author | Oberholzer, Laura | - |
dc.contributor.author | Haider, Thomas | - |
dc.contributor.author | Goetze, Jens P. | - |
dc.contributor.author | Meinild-Lundby, Anne Kristine | - |
dc.contributor.author | Lundby, Carsten | - |
dc.date.accessioned | 2020-10-12T08:06:03Z | - |
dc.date.available | 2020-10-12T08:06:03Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 2017, v. 312, n. 6, p. R894-R902 | - |
dc.identifier.issn | 0363-6119 | - |
dc.identifier.uri | http://hdl.handle.net/10722/288858 | - |
dc.description.abstract | © 2017 the American Physiological Society. The purpose of the present study was to characterize the progression of red blood cell volume (RBCV) expansion and potential volumetric and endocrine regulators of erythropoiesis during endurance training (ET). Nine healthy, untrained volunteers (age = 27 ± 4 yr) underwent supervised ET consisting of 3–4 × 60 min cycle ergometry sessions per week for 8 wk. Plasma volume (PV), RBCV, and overnight fasting hematological markers were determined before and at weeks 2, 4, and 8 of ET. In addition, plasma erythropoietin (EPO), cortisol, copeptin, and proatrial natriuretic peptide concentrations were measured during a 3-h morning period at baseline and postexercise at weeks 1 and 8. PV increased from baseline (2,405 ± 335 ml) at weeks 2, 4, and 8 (+374 ± 194, +505 ± 156, and +341 ± 160 ml, respectively, P 0.001). Increases in RBCV from baseline (1,737 ± 442 ml) were manifested at week 4 (+109 ± 114 ml, P = 0.030) and week 8 (+205 ± 109 ml, P = 0.001). Overnight fasting plasma EPO concentration increased from baseline (11.3 ± 4.8 mIU/ml) at week 2 (+2.5 ± 2.8 mIU·ml-1, P = 0.027) and returned to baseline concentration at weeks 4 and 8. Higher 3-h-postexercise EPO concentration was observed at week 1 (11.6 mIU/ml) compared with week 8 (8.4 ± 3.9 mIU/ml, P = 0.009) and baseline (9.0 ± 4.2 mIU/ml, P 0.019). Linear relationships between EPO concentration and hematocrit (β-56.2, P 0.001) and cortisol (β = 0.037, P 0.001) were detected throughout the ET intervention. In conclusion, ET leads to mild, transient increases in circulating EPO concentration, concurring with early PV expansion and lowered hematocrit, preceding gradual RBCV enhancement. | - |
dc.language | eng | - |
dc.relation.ispartof | American Journal of Physiology - Regulatory Integrative and Comparative Physiology | - |
dc.subject | Erythropoietin | - |
dc.subject | Exercise training | - |
dc.subject | Plasma volume | - |
dc.subject | Red blood cell volume | - |
dc.title | Erythropoiesis with endurance training: Dynamics and mechanisms | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1152/ajpregu.00012.2017 | - |
dc.identifier.pmid | 28381454 | - |
dc.identifier.scopus | eid_2-s2.0-85020215636 | - |
dc.identifier.volume | 312 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | R894 | - |
dc.identifier.epage | R902 | - |
dc.identifier.eissn | 1522-1490 | - |
dc.identifier.isi | WOS:000404379200005 | - |
dc.identifier.issnl | 0363-6119 | - |