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- Publisher Website: 10.1139/apnm-2018-0195
- Scopus: eid_2-s2.0-85057067186
- PMID: 29920224
- WOS: WOS:000451404100017
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Article: Increased capillary density in skeletal muscle is not associated with impaired insulin sensitivity induced by bed rest in healthy young men
Title | Increased capillary density in skeletal muscle is not associated with impaired insulin sensitivity induced by bed rest in healthy young men |
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Authors | |
Keywords | Insulin resistance Glucose tolerance Bed rest Skeletal muscle capillarization |
Issue Date | 2018 |
Citation | Applied Physiology, Nutrition and Metabolism, 2018, v. 43, n. 12, p. 1334-1340 How to Cite? |
Abstract | © 2018, Canadian Science Publishing. All rights reserved. Physical inactivity alters glucose homeostasis in skeletal muscle, potentially developing into overt metabolic disease. The present study sought to investigate the role of skeletal muscle capillarization in glucose tolerance and insulin sensitivity (IS) using a classic human model of physical inactivity. Thirteen healthy males (age = 23 ± 2 years) underwent 4 days of full-time supervised and diet-controlled bed rest. Oral glucose tolerance test, indices of IS (quantitative insulin sensitivity check index (QUICKI), Matsuda index), as well as skeletal muscle biopsies with measurement of fiber type distribution, fiber cross-sectional area (FCSA), capillary-to-fiber ratio (C/F ratio), and capillary density (CD) were assessed prior to and after bed rest. Body weight and composition were unaltered by bed rest. Fasting glucose/insulin ratio (G 0 /I 0 ratio) (−25%, P = 0.016), QUICKI (−7%, P = 0.023), and Matsuda index (−24%, P = 0.003) diminished with bed rest. Skeletal muscle FCSA decreased (−737.4 ± 763.2 μm −2 (−12%), P = 0.005) while C/F ratio was preserved, resulting in augmented CD (+93.9 ± 91.5 capillaries·mm −2 (+37%), P = 0.003) with bed rest. No association was detected between changes in skeletal muscle variables and metabolic outcomes. Independently of bed rest-induced effects, a positive linear relationship was detected between C/F ratio and G 0 /I 0 ratio (β = 17.09, P = 0.021). In conclusion, impaired glucose homeostasis with bed rest is not prevented nor associated with enhanced skeletal muscle capillarization in healthy individuals. |
Persistent Identifier | http://hdl.handle.net/10722/288762 |
ISSN | 2023 Impact Factor: 2.4 2023 SCImago Journal Rankings: 1.010 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Montero, David | - |
dc.contributor.author | Oberholzer, Laura | - |
dc.contributor.author | Haider, Thomas | - |
dc.contributor.author | Breenfeldt-Andersen, Andreas | - |
dc.contributor.author | Dandanell, Sune | - |
dc.contributor.author | Meinild-Lundby, Anne Kristine | - |
dc.contributor.author | Maconochie, Hannah | - |
dc.contributor.author | Lundby, Carsten | - |
dc.date.accessioned | 2020-10-12T08:05:48Z | - |
dc.date.available | 2020-10-12T08:05:48Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Applied Physiology, Nutrition and Metabolism, 2018, v. 43, n. 12, p. 1334-1340 | - |
dc.identifier.issn | 1715-5312 | - |
dc.identifier.uri | http://hdl.handle.net/10722/288762 | - |
dc.description.abstract | © 2018, Canadian Science Publishing. All rights reserved. Physical inactivity alters glucose homeostasis in skeletal muscle, potentially developing into overt metabolic disease. The present study sought to investigate the role of skeletal muscle capillarization in glucose tolerance and insulin sensitivity (IS) using a classic human model of physical inactivity. Thirteen healthy males (age = 23 ± 2 years) underwent 4 days of full-time supervised and diet-controlled bed rest. Oral glucose tolerance test, indices of IS (quantitative insulin sensitivity check index (QUICKI), Matsuda index), as well as skeletal muscle biopsies with measurement of fiber type distribution, fiber cross-sectional area (FCSA), capillary-to-fiber ratio (C/F ratio), and capillary density (CD) were assessed prior to and after bed rest. Body weight and composition were unaltered by bed rest. Fasting glucose/insulin ratio (G 0 /I 0 ratio) (−25%, P = 0.016), QUICKI (−7%, P = 0.023), and Matsuda index (−24%, P = 0.003) diminished with bed rest. Skeletal muscle FCSA decreased (−737.4 ± 763.2 μm −2 (−12%), P = 0.005) while C/F ratio was preserved, resulting in augmented CD (+93.9 ± 91.5 capillaries·mm −2 (+37%), P = 0.003) with bed rest. No association was detected between changes in skeletal muscle variables and metabolic outcomes. Independently of bed rest-induced effects, a positive linear relationship was detected between C/F ratio and G 0 /I 0 ratio (β = 17.09, P = 0.021). In conclusion, impaired glucose homeostasis with bed rest is not prevented nor associated with enhanced skeletal muscle capillarization in healthy individuals. | - |
dc.language | eng | - |
dc.relation.ispartof | Applied Physiology, Nutrition and Metabolism | - |
dc.subject | Insulin resistance | - |
dc.subject | Glucose tolerance | - |
dc.subject | Bed rest | - |
dc.subject | Skeletal muscle capillarization | - |
dc.title | Increased capillary density in skeletal muscle is not associated with impaired insulin sensitivity induced by bed rest in healthy young men | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1139/apnm-2018-0195 | - |
dc.identifier.pmid | 29920224 | - |
dc.identifier.scopus | eid_2-s2.0-85057067186 | - |
dc.identifier.volume | 43 | - |
dc.identifier.issue | 12 | - |
dc.identifier.spage | 1334 | - |
dc.identifier.epage | 1340 | - |
dc.identifier.eissn | 1715-5320 | - |
dc.identifier.isi | WOS:000451404100017 | - |
dc.identifier.issnl | 1715-5312 | - |