File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1111/apha.12827
- Scopus: eid_2-s2.0-85006355710
- PMID: 27888580
- WOS: WOS:000401539300008
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Biology of VO2 max: looking under the physiology lamp
Title | Biology of VO<inf>2</inf>max: looking under the physiology lamp |
---|---|
Authors | |
Keywords | genetics mitochondria red blood cell volume exercise non-responders performance |
Issue Date | 2017 |
Citation | Acta Physiologica, 2017, v. 220, n. 2, p. 218-228 How to Cite? |
Abstract | © 2016 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd In this review, we argue that several key features of maximal oxygen uptake (VO2max) should underpin discussions about the biological and reductionist determinants of its interindividual variability: (i) training-induced increases in VO2max are largely facilitated by expansion of red blood cell volume and an associated improvement in stroke volume, which also adapts independent of changes in red blood cell volume. These general concepts are also informed by cross-sectional studies in athletes that have very high values for VO2max. Therefore, (ii) variations in VO2max improvements with exercise training are also likely related to variations in these physiological determinants. (iii) All previously untrained individuals will respond to endurance exercise training in terms of improvements in VO2max provided the stimulus exceeds a certain volume and/or intensity. Thus, genetic analysis and/or reductionist studies performed to understand or predict such variations might focus specifically on DNA variants or other molecular phenomena of relevance to these physiological pathways. |
Persistent Identifier | http://hdl.handle.net/10722/288729 |
ISSN | 2023 Impact Factor: 5.6 2023 SCImago Journal Rankings: 1.433 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lundby, C. | - |
dc.contributor.author | Montero, D. | - |
dc.contributor.author | Joyner, M. | - |
dc.date.accessioned | 2020-10-12T08:05:43Z | - |
dc.date.available | 2020-10-12T08:05:43Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Acta Physiologica, 2017, v. 220, n. 2, p. 218-228 | - |
dc.identifier.issn | 1748-1708 | - |
dc.identifier.uri | http://hdl.handle.net/10722/288729 | - |
dc.description.abstract | © 2016 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd In this review, we argue that several key features of maximal oxygen uptake (VO2max) should underpin discussions about the biological and reductionist determinants of its interindividual variability: (i) training-induced increases in VO2max are largely facilitated by expansion of red blood cell volume and an associated improvement in stroke volume, which also adapts independent of changes in red blood cell volume. These general concepts are also informed by cross-sectional studies in athletes that have very high values for VO2max. Therefore, (ii) variations in VO2max improvements with exercise training are also likely related to variations in these physiological determinants. (iii) All previously untrained individuals will respond to endurance exercise training in terms of improvements in VO2max provided the stimulus exceeds a certain volume and/or intensity. Thus, genetic analysis and/or reductionist studies performed to understand or predict such variations might focus specifically on DNA variants or other molecular phenomena of relevance to these physiological pathways. | - |
dc.language | eng | - |
dc.relation.ispartof | Acta Physiologica | - |
dc.subject | genetics | - |
dc.subject | mitochondria | - |
dc.subject | red blood cell volume | - |
dc.subject | exercise | - |
dc.subject | non-responders | - |
dc.subject | performance | - |
dc.title | Biology of VO<inf>2</inf>max: looking under the physiology lamp | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/apha.12827 | - |
dc.identifier.pmid | 27888580 | - |
dc.identifier.scopus | eid_2-s2.0-85006355710 | - |
dc.identifier.volume | 220 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 218 | - |
dc.identifier.epage | 228 | - |
dc.identifier.eissn | 1748-1716 | - |
dc.identifier.isi | WOS:000401539300008 | - |
dc.identifier.issnl | 1748-1708 | - |