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Article: Children with Poor Reading Skills at the Word Level Show Reduced Fractional Anisotropy in White Matter Tracts of Both Hemispheres

TitleChildren with Poor Reading Skills at the Word Level Show Reduced Fractional Anisotropy in White Matter Tracts of Both Hemispheres
Authors
Keywordsstructural connectivity
white matter
tract-based spatial statistics
poor readers
diffusion tensor imaging
Issue Date2016
Citation
Brain Connectivity, 2016, v. 6, n. 7, p. 519-523 How to Cite?
Abstract© Copyright 2016, Mary Ann Liebert, Inc. 2016. Diffusion tensor imaging (DTI) studies showed that microstructural alterations are correlated to reading skills. In this study, we aim to investigate white matter microstructure of a group of Portuguese speakers with poor reading level, using different parameters of DTI. To perform this analysis, we selected children ranging from 8 to 12 years of age, poor readers (n = 17) and good readers (n = 23), evaluated in the word-level ability based on a Latent Class Analysis (LCA) of Academic Performance Test (TDE). Poor readers exhibited significant fractional anisotropy (FA) reductions in many tracts of both hemispheres, but small and restricted clusters of increased radial diffusivity (RD) in the left hemisphere. Spatial coherence of fibers might be the main source of differences, as changes in FA were not similarly accompanied in terms of extension by changes in RD. Widespread structural alterations in the white matter could prevent good reading ability at word level, which is consistent with recent studies demonstrating the involvement of multiple cortical regions and white matter tracts in reading disabilities.
Persistent Identifierhttp://hdl.handle.net/10722/288719
ISSN
2023 Impact Factor: 2.4
2023 SCImago Journal Rankings: 0.793
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDe Moura, Luciana Monteiro-
dc.contributor.authorCogo-Moreira, Hugo-
dc.contributor.authorDe Ávila, Clara Regina Brandão-
dc.contributor.authorPan, Pedro Mario-
dc.contributor.authorGadelha, Ary-
dc.contributor.authorMoriyama, Tais-
dc.contributor.authorDel Aquilla, Marco Antonio-
dc.contributor.authorHoexter, Marcelo-
dc.contributor.authorSalum, Giovanni Abrahão-
dc.contributor.authorPicon, Felipe Almeida-
dc.contributor.authorAnés, Mauricio-
dc.contributor.authorMercadante, Marcos Tomanik-
dc.contributor.authorLacerda, Acioly-
dc.contributor.authorAmaro, Edson-
dc.contributor.authorMiguel, Euripedes Constantino-
dc.contributor.authorRohde, Luis Augusto-
dc.contributor.authorBressan, Rodrigo Affonseca-
dc.contributor.authorMcGuire, Philip-
dc.contributor.authorSato, João Ricardo-
dc.contributor.authorDe Jesus Mari, Jair-
dc.contributor.authorJackowski, Andrea Parolin-
dc.date.accessioned2020-10-12T08:05:41Z-
dc.date.available2020-10-12T08:05:41Z-
dc.date.issued2016-
dc.identifier.citationBrain Connectivity, 2016, v. 6, n. 7, p. 519-523-
dc.identifier.issn2158-0014-
dc.identifier.urihttp://hdl.handle.net/10722/288719-
dc.description.abstract© Copyright 2016, Mary Ann Liebert, Inc. 2016. Diffusion tensor imaging (DTI) studies showed that microstructural alterations are correlated to reading skills. In this study, we aim to investigate white matter microstructure of a group of Portuguese speakers with poor reading level, using different parameters of DTI. To perform this analysis, we selected children ranging from 8 to 12 years of age, poor readers (n = 17) and good readers (n = 23), evaluated in the word-level ability based on a Latent Class Analysis (LCA) of Academic Performance Test (TDE). Poor readers exhibited significant fractional anisotropy (FA) reductions in many tracts of both hemispheres, but small and restricted clusters of increased radial diffusivity (RD) in the left hemisphere. Spatial coherence of fibers might be the main source of differences, as changes in FA were not similarly accompanied in terms of extension by changes in RD. Widespread structural alterations in the white matter could prevent good reading ability at word level, which is consistent with recent studies demonstrating the involvement of multiple cortical regions and white matter tracts in reading disabilities.-
dc.languageeng-
dc.relation.ispartofBrain Connectivity-
dc.subjectstructural connectivity-
dc.subjectwhite matter-
dc.subjecttract-based spatial statistics-
dc.subjectpoor readers-
dc.subjectdiffusion tensor imaging-
dc.titleChildren with Poor Reading Skills at the Word Level Show Reduced Fractional Anisotropy in White Matter Tracts of Both Hemispheres-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1089/brain.2016.0430-
dc.identifier.pmid27353747-
dc.identifier.scopuseid_2-s2.0-84987859185-
dc.identifier.volume6-
dc.identifier.issue7-
dc.identifier.spage519-
dc.identifier.epage523-
dc.identifier.eissn2158-0022-
dc.identifier.isiWOS:000448210700001-
dc.identifier.issnl2158-0014-

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