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- Publisher Website: 10.1089/brain.2016.0430
- Scopus: eid_2-s2.0-84987859185
- PMID: 27353747
- WOS: WOS:000448210700001
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Article: Children with Poor Reading Skills at the Word Level Show Reduced Fractional Anisotropy in White Matter Tracts of Both Hemispheres
Title | Children with Poor Reading Skills at the Word Level Show Reduced Fractional Anisotropy in White Matter Tracts of Both Hemispheres |
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Authors | De Moura, Luciana MonteiroCogo-Moreira, HugoDe Ávila, Clara Regina BrandãoPan, Pedro MarioGadelha, AryMoriyama, TaisDel Aquilla, Marco AntonioHoexter, MarceloSalum, Giovanni AbrahãoPicon, Felipe AlmeidaAnés, MauricioMercadante, Marcos TomanikLacerda, AciolyAmaro, EdsonMiguel, Euripedes ConstantinoRohde, Luis AugustoBressan, Rodrigo AffonsecaMcGuire, PhilipSato, João RicardoDe Jesus Mari, JairJackowski, Andrea Parolin |
Keywords | structural connectivity white matter tract-based spatial statistics poor readers diffusion tensor imaging |
Issue Date | 2016 |
Citation | Brain Connectivity, 2016, v. 6, n. 7, p. 519-523 How to Cite? |
Abstract | © Copyright 2016, Mary Ann Liebert, Inc. 2016. Diffusion tensor imaging (DTI) studies showed that microstructural alterations are correlated to reading skills. In this study, we aim to investigate white matter microstructure of a group of Portuguese speakers with poor reading level, using different parameters of DTI. To perform this analysis, we selected children ranging from 8 to 12 years of age, poor readers (n = 17) and good readers (n = 23), evaluated in the word-level ability based on a Latent Class Analysis (LCA) of Academic Performance Test (TDE). Poor readers exhibited significant fractional anisotropy (FA) reductions in many tracts of both hemispheres, but small and restricted clusters of increased radial diffusivity (RD) in the left hemisphere. Spatial coherence of fibers might be the main source of differences, as changes in FA were not similarly accompanied in terms of extension by changes in RD. Widespread structural alterations in the white matter could prevent good reading ability at word level, which is consistent with recent studies demonstrating the involvement of multiple cortical regions and white matter tracts in reading disabilities. |
Persistent Identifier | http://hdl.handle.net/10722/288719 |
ISSN | 2023 Impact Factor: 2.4 2023 SCImago Journal Rankings: 0.793 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | De Moura, Luciana Monteiro | - |
dc.contributor.author | Cogo-Moreira, Hugo | - |
dc.contributor.author | De Ávila, Clara Regina Brandão | - |
dc.contributor.author | Pan, Pedro Mario | - |
dc.contributor.author | Gadelha, Ary | - |
dc.contributor.author | Moriyama, Tais | - |
dc.contributor.author | Del Aquilla, Marco Antonio | - |
dc.contributor.author | Hoexter, Marcelo | - |
dc.contributor.author | Salum, Giovanni Abrahão | - |
dc.contributor.author | Picon, Felipe Almeida | - |
dc.contributor.author | Anés, Mauricio | - |
dc.contributor.author | Mercadante, Marcos Tomanik | - |
dc.contributor.author | Lacerda, Acioly | - |
dc.contributor.author | Amaro, Edson | - |
dc.contributor.author | Miguel, Euripedes Constantino | - |
dc.contributor.author | Rohde, Luis Augusto | - |
dc.contributor.author | Bressan, Rodrigo Affonseca | - |
dc.contributor.author | McGuire, Philip | - |
dc.contributor.author | Sato, João Ricardo | - |
dc.contributor.author | De Jesus Mari, Jair | - |
dc.contributor.author | Jackowski, Andrea Parolin | - |
dc.date.accessioned | 2020-10-12T08:05:41Z | - |
dc.date.available | 2020-10-12T08:05:41Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Brain Connectivity, 2016, v. 6, n. 7, p. 519-523 | - |
dc.identifier.issn | 2158-0014 | - |
dc.identifier.uri | http://hdl.handle.net/10722/288719 | - |
dc.description.abstract | © Copyright 2016, Mary Ann Liebert, Inc. 2016. Diffusion tensor imaging (DTI) studies showed that microstructural alterations are correlated to reading skills. In this study, we aim to investigate white matter microstructure of a group of Portuguese speakers with poor reading level, using different parameters of DTI. To perform this analysis, we selected children ranging from 8 to 12 years of age, poor readers (n = 17) and good readers (n = 23), evaluated in the word-level ability based on a Latent Class Analysis (LCA) of Academic Performance Test (TDE). Poor readers exhibited significant fractional anisotropy (FA) reductions in many tracts of both hemispheres, but small and restricted clusters of increased radial diffusivity (RD) in the left hemisphere. Spatial coherence of fibers might be the main source of differences, as changes in FA were not similarly accompanied in terms of extension by changes in RD. Widespread structural alterations in the white matter could prevent good reading ability at word level, which is consistent with recent studies demonstrating the involvement of multiple cortical regions and white matter tracts in reading disabilities. | - |
dc.language | eng | - |
dc.relation.ispartof | Brain Connectivity | - |
dc.subject | structural connectivity | - |
dc.subject | white matter | - |
dc.subject | tract-based spatial statistics | - |
dc.subject | poor readers | - |
dc.subject | diffusion tensor imaging | - |
dc.title | Children with Poor Reading Skills at the Word Level Show Reduced Fractional Anisotropy in White Matter Tracts of Both Hemispheres | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1089/brain.2016.0430 | - |
dc.identifier.pmid | 27353747 | - |
dc.identifier.scopus | eid_2-s2.0-84987859185 | - |
dc.identifier.volume | 6 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 519 | - |
dc.identifier.epage | 523 | - |
dc.identifier.eissn | 2158-0022 | - |
dc.identifier.isi | WOS:000448210700001 | - |
dc.identifier.issnl | 2158-0014 | - |