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Article: Genetic characterization of Enterovirus 71 strains circulating in Vietnam in 2012

TitleGenetic characterization of Enterovirus 71 strains circulating in Vietnam in 2012
Authors
KeywordsOutbreak
Vietnam
Enterovirus 71
Phylogenetics
C4 subgenogroup
Issue Date2016
Citation
Virology, 2016, v. 495, p. 1-9 How to Cite?
Abstract© 2016 The Authors. Background: Enterovirus 71 subgenogroup C4 caused the largest outbreak of Hand, Foot and Mouth Disease (HFMD) in Vietnam during 2011-2012, resulting in over 200,000 hospitalisations and 207 fatalities. Methods: A total of 1917 samples with adequate volume for RT-PCR analysis were collected from patients hospitalised with HFMD throughout Vietnam and 637 were positive for EV71. VP1 gene (n=87) and complete genome (n=9) sequencing was performed. Maximum-likelihood phylogenetic analysis was performed to characterise the B5, C4 and C5 strains detected. Results: Sequence analyses revealed that the dominant subgenogroup associated with the 2012 outbreak was C4, with B5 and C5 strains representing a small proportion of these cases. Conclusions: Numerous countries in the region including Malaysia, Taiwan and China have a large influence on strain diversity in Vietnam and understanding the transmission of EV71 throughout Southeast Asia is vital to inform preventative public health measures and vaccine development efforts.
Persistent Identifierhttp://hdl.handle.net/10722/288701
ISSN
2023 Impact Factor: 2.8
2023 SCImago Journal Rankings: 0.838
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDonato, Celeste-
dc.contributor.authorHoi, Le Thi-
dc.contributor.authorHoa, Nguyen Thi-
dc.contributor.authorHoa, Tran Mai-
dc.contributor.authorVan Duyet, Le-
dc.contributor.authorDieu Ngan, Ta Thi-
dc.contributor.authorVan Kinh, Nguyen-
dc.contributor.authorVu Trung, Nguyen-
dc.contributor.authorVijaykrishna, Dhanasekaran-
dc.date.accessioned2020-10-12T08:05:39Z-
dc.date.available2020-10-12T08:05:39Z-
dc.date.issued2016-
dc.identifier.citationVirology, 2016, v. 495, p. 1-9-
dc.identifier.issn0042-6822-
dc.identifier.urihttp://hdl.handle.net/10722/288701-
dc.description.abstract© 2016 The Authors. Background: Enterovirus 71 subgenogroup C4 caused the largest outbreak of Hand, Foot and Mouth Disease (HFMD) in Vietnam during 2011-2012, resulting in over 200,000 hospitalisations and 207 fatalities. Methods: A total of 1917 samples with adequate volume for RT-PCR analysis were collected from patients hospitalised with HFMD throughout Vietnam and 637 were positive for EV71. VP1 gene (n=87) and complete genome (n=9) sequencing was performed. Maximum-likelihood phylogenetic analysis was performed to characterise the B5, C4 and C5 strains detected. Results: Sequence analyses revealed that the dominant subgenogroup associated with the 2012 outbreak was C4, with B5 and C5 strains representing a small proportion of these cases. Conclusions: Numerous countries in the region including Malaysia, Taiwan and China have a large influence on strain diversity in Vietnam and understanding the transmission of EV71 throughout Southeast Asia is vital to inform preventative public health measures and vaccine development efforts.-
dc.languageeng-
dc.relation.ispartofVirology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectOutbreak-
dc.subjectVietnam-
dc.subjectEnterovirus 71-
dc.subjectPhylogenetics-
dc.subjectC4 subgenogroup-
dc.titleGenetic characterization of Enterovirus 71 strains circulating in Vietnam in 2012-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.virol.2016.04.026-
dc.identifier.pmid27148893-
dc.identifier.scopuseid_2-s2.0-84966378367-
dc.identifier.volume495-
dc.identifier.spage1-
dc.identifier.epage9-
dc.identifier.eissn1096-0341-
dc.identifier.isiWOS:000378659900001-
dc.identifier.issnl0042-6822-

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