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- Publisher Website: 10.1016/j.vetmic.2014.09.017
- Scopus: eid_2-s2.0-84909950683
- PMID: 25301283
- WOS: WOS:000345180500029
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Article: Identification and molecular characterization of novel and divergent HoBi-like pestiviruses from naturally infected cattle in India
Title | Identification and molecular characterization of novel and divergent HoBi-like pestiviruses from naturally infected cattle in India |
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Authors | |
Keywords | 5'-UTR Antigenic characterization HoBi-like virus Phylogenetic analysis N pro Cattle |
Issue Date | 2014 |
Citation | Veterinary Microbiology, 2014, v. 174, n. 1-2, p. 239-246 How to Cite? |
Abstract | © 2014 Elsevier B.V. HoBi-like pestiviruses have been sporadically reported from naturally infected cattle in South America, Asia and Europe. While the closely related bovine viral diarrhoea virus 1 (BVDV-1) and BVDV-2 have been reported from cattle in India, the prevalence and diversity of HoBi-like viruses have not yet been studied. Here we report the genetic diversity and molecular characteristics of HoBi-like viruses, through systematic surveillance in cattle (n=1049) from 21 dairy farms across India during 2012-2013. On the basis of real-time RT-PCR, virus isolation and nucleotide sequencing results, of the 20 pestivirus positive cattle, HoBi-like viruses were identified in 19 cattle from four farms in three states and BVDV-1b in one cattle. Phylogenetic analysis of 5'-UTR and Npro region identified the circulation of two lineages of HoBi-like viruses in India, that were distinct to those circulating globally, highlighting the independent evolution of at least three lineages of HoBi-like viruses globally. Antigenic differences were also evident between the two Indian lineages. In addition to revealing that HoBi-like virus may be more widespread in Indian cattle than previously reported, this study shows greater genetic divergence of HoBi-like viruses indicating a need for continued pestivirus surveillance in cattle. |
Persistent Identifier | http://hdl.handle.net/10722/288638 |
ISSN | 2021 Impact Factor: 3.246 2020 SCImago Journal Rankings: 1.155 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Mishra, N. | - |
dc.contributor.author | Rajukumar, K. | - |
dc.contributor.author | Pateriya, A. | - |
dc.contributor.author | Kumar, M. | - |
dc.contributor.author | Dubey, P. | - |
dc.contributor.author | Behera, S. P. | - |
dc.contributor.author | Verma, A. | - |
dc.contributor.author | Bhardwaj, P. | - |
dc.contributor.author | Kulkarni, D. D. | - |
dc.contributor.author | Vijaykrishna, D. | - |
dc.contributor.author | Reddy, N. D. | - |
dc.date.accessioned | 2020-10-12T08:05:28Z | - |
dc.date.available | 2020-10-12T08:05:28Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Veterinary Microbiology, 2014, v. 174, n. 1-2, p. 239-246 | - |
dc.identifier.issn | 0378-1135 | - |
dc.identifier.uri | http://hdl.handle.net/10722/288638 | - |
dc.description.abstract | © 2014 Elsevier B.V. HoBi-like pestiviruses have been sporadically reported from naturally infected cattle in South America, Asia and Europe. While the closely related bovine viral diarrhoea virus 1 (BVDV-1) and BVDV-2 have been reported from cattle in India, the prevalence and diversity of HoBi-like viruses have not yet been studied. Here we report the genetic diversity and molecular characteristics of HoBi-like viruses, through systematic surveillance in cattle (n=1049) from 21 dairy farms across India during 2012-2013. On the basis of real-time RT-PCR, virus isolation and nucleotide sequencing results, of the 20 pestivirus positive cattle, HoBi-like viruses were identified in 19 cattle from four farms in three states and BVDV-1b in one cattle. Phylogenetic analysis of 5'-UTR and Npro region identified the circulation of two lineages of HoBi-like viruses in India, that were distinct to those circulating globally, highlighting the independent evolution of at least three lineages of HoBi-like viruses globally. Antigenic differences were also evident between the two Indian lineages. In addition to revealing that HoBi-like virus may be more widespread in Indian cattle than previously reported, this study shows greater genetic divergence of HoBi-like viruses indicating a need for continued pestivirus surveillance in cattle. | - |
dc.language | eng | - |
dc.relation.ispartof | Veterinary Microbiology | - |
dc.subject | 5'-UTR | - |
dc.subject | Antigenic characterization | - |
dc.subject | HoBi-like virus | - |
dc.subject | Phylogenetic analysis | - |
dc.subject | N pro | - |
dc.subject | Cattle | - |
dc.title | Identification and molecular characterization of novel and divergent HoBi-like pestiviruses from naturally infected cattle in India | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.vetmic.2014.09.017 | - |
dc.identifier.pmid | 25301283 | - |
dc.identifier.scopus | eid_2-s2.0-84909950683 | - |
dc.identifier.volume | 174 | - |
dc.identifier.issue | 1-2 | - |
dc.identifier.spage | 239 | - |
dc.identifier.epage | 246 | - |
dc.identifier.eissn | 1873-2542 | - |
dc.identifier.isi | WOS:000345180500029 | - |
dc.identifier.issnl | 0378-1135 | - |