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- Publisher Website: 10.1038/s41467-020-18592-5
- Scopus: eid_2-s2.0-85091408424
- PMID: 32968048
- WOS: WOS:000573746700008
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Article: REM sleep promotes experience-dependent dendritic spine elimination in the mouse cortex
Title | REM sleep promotes experience-dependent dendritic spine elimination in the mouse cortex |
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Authors | |
Keywords | animal cell animal experiment animal tissue association cortex auditory stimulation |
Issue Date | 2020 |
Publisher | Nature Research (part of Springer Nature): Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html |
Citation | Nature Communications, 2020, v. 11, p. article no. 4819 How to Cite? |
Abstract | In many parts of the nervous system, experience-dependent refinement of neuronal circuits predominantly involves synapse elimination. The role of sleep in this process remains unknown. We investigated the role of sleep in experience-dependent dendritic spine elimination of layer 5 pyramidal neurons in the visual (V1) and frontal association cortex (FrA) of 1-month-old mice. We found that monocular deprivation (MD) or auditory-cued fear conditioning (FC) caused rapid spine elimination in V1 or FrA, respectively. MD- or FC-induced spine elimination was significantly reduced after total sleep or REM sleep deprivation. Total sleep or REM sleep deprivation also prevented MD- and FC-induced reduction of neuronal activity in response to visual or conditioned auditory stimuli. Furthermore, dendritic calcium spikes increased substantially during REM sleep, and the blockade of these calcium spikes prevented MD- and FC-induced spine elimination. These findings reveal an important role of REM sleep in experience-dependent synapse elimination and neuronal activity reduction. |
Persistent Identifier | http://hdl.handle.net/10722/288397 |
ISSN | 2023 Impact Factor: 14.7 2023 SCImago Journal Rankings: 4.887 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zhou, Y | - |
dc.contributor.author | Lai, SWC | - |
dc.contributor.author | Bai, Y | - |
dc.contributor.author | Li, W | - |
dc.contributor.author | Yang, G | - |
dc.contributor.author | Frank, M.G. | - |
dc.contributor.author | Gan, W.-B. | - |
dc.date.accessioned | 2020-10-05T12:12:17Z | - |
dc.date.available | 2020-10-05T12:12:17Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Nature Communications, 2020, v. 11, p. article no. 4819 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/10722/288397 | - |
dc.description.abstract | In many parts of the nervous system, experience-dependent refinement of neuronal circuits predominantly involves synapse elimination. The role of sleep in this process remains unknown. We investigated the role of sleep in experience-dependent dendritic spine elimination of layer 5 pyramidal neurons in the visual (V1) and frontal association cortex (FrA) of 1-month-old mice. We found that monocular deprivation (MD) or auditory-cued fear conditioning (FC) caused rapid spine elimination in V1 or FrA, respectively. MD- or FC-induced spine elimination was significantly reduced after total sleep or REM sleep deprivation. Total sleep or REM sleep deprivation also prevented MD- and FC-induced reduction of neuronal activity in response to visual or conditioned auditory stimuli. Furthermore, dendritic calcium spikes increased substantially during REM sleep, and the blockade of these calcium spikes prevented MD- and FC-induced spine elimination. These findings reveal an important role of REM sleep in experience-dependent synapse elimination and neuronal activity reduction. | - |
dc.language | eng | - |
dc.publisher | Nature Research (part of Springer Nature): Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html | - |
dc.relation.ispartof | Nature Communications | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | animal cell | - |
dc.subject | animal experiment | - |
dc.subject | animal tissue | - |
dc.subject | association cortex | - |
dc.subject | auditory stimulation | - |
dc.title | REM sleep promotes experience-dependent dendritic spine elimination in the mouse cortex | - |
dc.type | Article | - |
dc.identifier.email | Lai, SWC: coraswl@hku.hk | - |
dc.identifier.authority | Lai, SWC=rp01895 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1038/s41467-020-18592-5 | - |
dc.identifier.pmid | 32968048 | - |
dc.identifier.pmcid | PMC7511313 | - |
dc.identifier.scopus | eid_2-s2.0-85091408424 | - |
dc.identifier.hkuros | 315265 | - |
dc.identifier.volume | 11 | - |
dc.identifier.spage | article no. 4819 | - |
dc.identifier.epage | article no. 4819 | - |
dc.identifier.isi | WOS:000573746700008 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 2041-1723 | - |