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Conference Paper: Bariatric surgery and risks of renal diseases, cardiovascular diseases and mortality among patients with type 2 diabetes mellitus
Title | Bariatric surgery and risks of renal diseases, cardiovascular diseases and mortality among patients with type 2 diabetes mellitus |
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Authors | |
Issue Date | 2020 |
Publisher | Oxford University Press. The Journal's web site is located at http://ndt.oxfordjournals.org/ |
Citation | 57th European Renal Association and European Dialysis and Transplant Association (ERA-EDTA) Congress, 6-9 June 2020. 57th ERA-EDTA Congress Abstracts in Nephrology Dialysis Transplantation, 2020, v. 35 n. Suppl. 3, p. iii1363, abstract no. P1039 How to Cite? |
Abstract | Background and Aims: To measure and compare the risks of end-stage renal diseases (ESRD), cardiovascular diseases (CVD), all-cause mortality between obese type 2 diabetes mellitus (T2DM) patients with and without bariatric surgery.
Method: A retrospective population-based cohort of 1,690 obese T2DM patients who were free of ESRD and CVD were assembled based on 2006-2017 Hospital Authority database. One-to-five propensity-score matching was used to balance baseline covariates between patients in bariatric surgery and control groups. Incidence rates (IR) of stage 4/5 chronic renal diseases, ESRD, CVD and all-cause mortality events for two groups were calculated. Hazard ratios (HR) for stage 4/5 chronic renal diseases, ESRD, CVD events were assessed using Cox proportional hazard models. Changes in estimated glomerular filtration rate (eGFR), and urine albumin-creatinine ratio (UACR) were measured up to 60 months.
Results: Over a mean follow-up period of 34 months with 863 person-years, cumulative incidences of mortality, stage 4/5 chronic kidney diseases, ESRD and CVD for surgical patients were 0, 0.050, 0.017, and 0.036, respectively. Surgical patients had reduced IR of all-cause mortality, stage 4/5 chronic kidney diseases, ESRD and CVD (IR=0, 1.784, 0.587 and 1.321 per 100 person-years, respectively) than control patients (IR=1.954, 2.028, 0.914 and 2.814 per 100 person-years, respectively). Surgery group had a significant reduction in risk of CVD events (HR=0.464, P=0.015), and no occurrence of mortality events. However, the IR of stage 4/5 chronic kidney diseases and ESRD of the two groups were not significantly different. Surgical patients had significantly higher eGFR within 12 months, and had significantly lower until 48 months.
Conclusion: Among obese T2DM patients, bariatric surgery lowered the risk of CVD and mortality, and was beneficial towards the kidney outcomes of eGFR up to 36 months. |
Persistent Identifier | http://hdl.handle.net/10722/288391 |
ISSN | 2023 Impact Factor: 4.8 2023 SCImago Journal Rankings: 1.414 |
DC Field | Value | Language |
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dc.contributor.author | Wong, CKH | - |
dc.contributor.author | Wu, T | - |
dc.contributor.author | Wong, SKH | - |
dc.contributor.author | Law, TT | - |
dc.contributor.author | Grieve, E | - |
dc.contributor.author | Wu, O | - |
dc.contributor.author | Lam, CLK | - |
dc.date.accessioned | 2020-10-05T12:12:11Z | - |
dc.date.available | 2020-10-05T12:12:11Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | 57th European Renal Association and European Dialysis and Transplant Association (ERA-EDTA) Congress, 6-9 June 2020. 57th ERA-EDTA Congress Abstracts in Nephrology Dialysis Transplantation, 2020, v. 35 n. Suppl. 3, p. iii1363, abstract no. P1039 | - |
dc.identifier.issn | 0931-0509 | - |
dc.identifier.uri | http://hdl.handle.net/10722/288391 | - |
dc.description.abstract | Background and Aims: To measure and compare the risks of end-stage renal diseases (ESRD), cardiovascular diseases (CVD), all-cause mortality between obese type 2 diabetes mellitus (T2DM) patients with and without bariatric surgery. Method: A retrospective population-based cohort of 1,690 obese T2DM patients who were free of ESRD and CVD were assembled based on 2006-2017 Hospital Authority database. One-to-five propensity-score matching was used to balance baseline covariates between patients in bariatric surgery and control groups. Incidence rates (IR) of stage 4/5 chronic renal diseases, ESRD, CVD and all-cause mortality events for two groups were calculated. Hazard ratios (HR) for stage 4/5 chronic renal diseases, ESRD, CVD events were assessed using Cox proportional hazard models. Changes in estimated glomerular filtration rate (eGFR), and urine albumin-creatinine ratio (UACR) were measured up to 60 months. Results: Over a mean follow-up period of 34 months with 863 person-years, cumulative incidences of mortality, stage 4/5 chronic kidney diseases, ESRD and CVD for surgical patients were 0, 0.050, 0.017, and 0.036, respectively. Surgical patients had reduced IR of all-cause mortality, stage 4/5 chronic kidney diseases, ESRD and CVD (IR=0, 1.784, 0.587 and 1.321 per 100 person-years, respectively) than control patients (IR=1.954, 2.028, 0.914 and 2.814 per 100 person-years, respectively). Surgery group had a significant reduction in risk of CVD events (HR=0.464, P=0.015), and no occurrence of mortality events. However, the IR of stage 4/5 chronic kidney diseases and ESRD of the two groups were not significantly different. Surgical patients had significantly higher eGFR within 12 months, and had significantly lower until 48 months. Conclusion: Among obese T2DM patients, bariatric surgery lowered the risk of CVD and mortality, and was beneficial towards the kidney outcomes of eGFR up to 36 months. | - |
dc.language | eng | - |
dc.publisher | Oxford University Press. The Journal's web site is located at http://ndt.oxfordjournals.org/ | - |
dc.relation.ispartof | Nephrology Dialysis Transplantation | - |
dc.relation.ispartof | 57th ERA-EDTA Congress, 2020 | - |
dc.title | Bariatric surgery and risks of renal diseases, cardiovascular diseases and mortality among patients with type 2 diabetes mellitus | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Wong, CKH: carlosho@hku.hk | - |
dc.identifier.email | Lam, CLK: clklam@hku.hk | - |
dc.identifier.authority | Wong, CKH=rp01931 | - |
dc.identifier.authority | Lam, CLK=rp00350 | - |
dc.description.nature | abstract | - |
dc.identifier.doi | 10.1093/ndt/gfaa142.P1039 | - |
dc.identifier.hkuros | 314633 | - |
dc.identifier.volume | 35 | - |
dc.identifier.issue | Suppl. 3 | - |
dc.identifier.spage | iii1363, abstract no. P1039 | - |
dc.identifier.epage | iii1363, abstract no. P1039 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0931-0509 | - |