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Article: Effects of dietary and physical activity interventions on generic and cancer-specific health related quality of life, anxiety and depression in colorectal cancer survivors: a randomized controlled trial

TitleEffects of dietary and physical activity interventions on generic and cancer-specific health related quality of life, anxiety and depression in colorectal cancer survivors: a randomized controlled trial
Authors
KeywordsHealth-related quality of life
Anxiety
Depression
Colorectal cancer
Cancer survivorship
Issue Date2020
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.com/journal/11764
Citation
Journal of Cancer Survivorship, 2020, v. 14, p. 424-433 How to Cite?
AbstractPurpose: To assess the effects of dietary and physical activity (PA) interventions on generic and cancer-specific quality of life (QoL), anxiety, and depression levels among adult Chinese colorectal cancer (CRC) survivors. Methods: Two-hundred twenty-three adult CRC survivors within 1 year of completion of primary cancer treatment were randomized to receive dietary, PA or combined intervention, or usual care for a 12 monthduration, under a 2 (diet vs usual care) × 2 (PA vs usual care) factorial design. Generic and cancer-specific QoL was assessed using a Chinese version 12-Item Short Form Health Survey (SF-12) and the Functional Assessment of Cancer Therapy-Colorectal (FACT-C) scale, respectively. Anxiety and depression was assessed using the Hospital Anxiety and Depression Scale at baseline, 6, 12, 18, and 24 months. Linear mixed models were used for examining the intervention effects. Results: Participants receiving dietary intervention experienced a significant improvement in the generic measure of QoL (SF-6D utility scores, mean difference 0.042, 95%CI 0.03 to 0.081) at 12 months, the cancer-specific QoL scores (mean difference 3.09, 95%CI 0.13 to 6.04), and levels of depression (P = 0.015) at both 12 and 24 months follow-up. Participants receiving PA intervention only demonstrated a significant improvement in SF-6D utility index (mean difference 0.039, 95%CI 0.002 to 0.077) and physical functioning (mean difference 2.85, 95%CI 1.00 to 4.70) at 6 months. Conclusions: Dietary intervention improved the generic and cancer-specific QoL and depression in CRC survivors. Trial registration: The study was prospectively registered on 17 October 2012 at ClinicalTrials.gov (NCT01708824). Implications for Cancer Survivors: CRC survivors can benefit from dietary interventions in alleviating depression and improving overall health-related QoL.
Persistent Identifierhttp://hdl.handle.net/10722/288383
ISSN
2023 Impact Factor: 3.1
2023 SCImago Journal Rankings: 1.201
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHo, M-
dc.contributor.authorHo, JWC-
dc.contributor.authorFong, DYT-
dc.contributor.authorLee, CF-
dc.contributor.authorMacfarlane, DJ-
dc.contributor.authorCerin, E-
dc.contributor.authorLee, AM-
dc.contributor.authorLeung, S-
dc.contributor.authorChan, WYY-
dc.contributor.authorLeung, IPF-
dc.contributor.authorLam, SHS-
dc.contributor.authorCHU, N-
dc.contributor.authorTaylor, AJ-
dc.contributor.authorCheng, KK-
dc.date.accessioned2020-10-05T12:12:04Z-
dc.date.available2020-10-05T12:12:04Z-
dc.date.issued2020-
dc.identifier.citationJournal of Cancer Survivorship, 2020, v. 14, p. 424-433-
dc.identifier.issn1932-2259-
dc.identifier.urihttp://hdl.handle.net/10722/288383-
dc.description.abstractPurpose: To assess the effects of dietary and physical activity (PA) interventions on generic and cancer-specific quality of life (QoL), anxiety, and depression levels among adult Chinese colorectal cancer (CRC) survivors. Methods: Two-hundred twenty-three adult CRC survivors within 1 year of completion of primary cancer treatment were randomized to receive dietary, PA or combined intervention, or usual care for a 12 monthduration, under a 2 (diet vs usual care) × 2 (PA vs usual care) factorial design. Generic and cancer-specific QoL was assessed using a Chinese version 12-Item Short Form Health Survey (SF-12) and the Functional Assessment of Cancer Therapy-Colorectal (FACT-C) scale, respectively. Anxiety and depression was assessed using the Hospital Anxiety and Depression Scale at baseline, 6, 12, 18, and 24 months. Linear mixed models were used for examining the intervention effects. Results: Participants receiving dietary intervention experienced a significant improvement in the generic measure of QoL (SF-6D utility scores, mean difference 0.042, 95%CI 0.03 to 0.081) at 12 months, the cancer-specific QoL scores (mean difference 3.09, 95%CI 0.13 to 6.04), and levels of depression (P = 0.015) at both 12 and 24 months follow-up. Participants receiving PA intervention only demonstrated a significant improvement in SF-6D utility index (mean difference 0.039, 95%CI 0.002 to 0.077) and physical functioning (mean difference 2.85, 95%CI 1.00 to 4.70) at 6 months. Conclusions: Dietary intervention improved the generic and cancer-specific QoL and depression in CRC survivors. Trial registration: The study was prospectively registered on 17 October 2012 at ClinicalTrials.gov (NCT01708824). Implications for Cancer Survivors: CRC survivors can benefit from dietary interventions in alleviating depression and improving overall health-related QoL.-
dc.languageeng-
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.com/journal/11764-
dc.relation.ispartofJournal of Cancer Survivorship-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectHealth-related quality of life-
dc.subjectAnxiety-
dc.subjectDepression-
dc.subjectColorectal cancer-
dc.subjectCancer survivorship-
dc.titleEffects of dietary and physical activity interventions on generic and cancer-specific health related quality of life, anxiety and depression in colorectal cancer survivors: a randomized controlled trial-
dc.typeArticle-
dc.identifier.emailHo, M: mandyho1@hku.hk-
dc.identifier.emailHo, JWC: judyho@hkucc.hku.hk-
dc.identifier.emailFong, DYT: dytfong@hku.hk-
dc.identifier.emailCerin, E: ecerin@hku.hk-
dc.identifier.emailLee, AM: amlee@hku.hk-
dc.identifier.authorityHo, M=rp02226-
dc.identifier.authorityFong, DYT=rp00253-
dc.identifier.authorityLee, CF=rp02103-
dc.identifier.authorityMacfarlane, DJ=rp00934-
dc.identifier.authorityCerin, E=rp00890-
dc.identifier.authorityLee, AM=rp00483-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1007/s11764-020-00864-0-
dc.identifier.pmid32072434-
dc.identifier.pmcidPMC7360640-
dc.identifier.scopuseid_2-s2.0-85079784022-
dc.identifier.hkuros315615-
dc.identifier.volume14-
dc.identifier.spage424-
dc.identifier.epage433-
dc.identifier.isiWOS:000516319900001-
dc.publisher.placeUnited States-
dc.identifier.issnl1932-2259-

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