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Article: In vitro fertilization add-ons for the endometrium: it doesn’t add-up

TitleIn vitro fertilization add-ons for the endometrium: it doesn’t add-up
Authors
KeywordsIVF add-on
treatment add-on
adjuvant
IVF adjunct
Issue Date2019
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/fertnstert
Citation
Fertility and Sterility, 2019, v. 112 n. 6, p. 987-993 How to Cite?
AbstractThe probability of live birth from an in vitro fertilization (IVF) cycle is modest. Many additional treatments (add-ons) are available which promise to improve the success of IVF. This review summarizes the current evidence for common IVF add-ons which are suggested to improve endometrial receptivity. Systematic reviews of randomized controlled trials and individual trials were included. Five add-ons were included: immune therapies, endometrial scratching, endometrial receptivity array, uterine artery vasodilation, and human chorionic gonadotropin instillation. The results suggest there is no robust evidence that these add-ons are effective or safe. Many IVF add-ons are costly, consuming precious resources which may be better spent on evidence-based treatments or further IVF. Large randomized controlled trials and appropriate safety assessment should be mandatory before the introduction of IVF add-ons into routine practice.
Persistent Identifierhttp://hdl.handle.net/10722/288204
ISSN
2023 Impact Factor: 6.6
2023 SCImago Journal Rankings: 1.858
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLensen, S-
dc.contributor.authorShreeve, N-
dc.contributor.authorBarnhart, KT-
dc.contributor.authorGibreel, A-
dc.contributor.authorNg, EHY-
dc.contributor.authorMoffett, A-
dc.date.accessioned2020-10-05T12:09:23Z-
dc.date.available2020-10-05T12:09:23Z-
dc.date.issued2019-
dc.identifier.citationFertility and Sterility, 2019, v. 112 n. 6, p. 987-993-
dc.identifier.issn0015-0282-
dc.identifier.urihttp://hdl.handle.net/10722/288204-
dc.description.abstractThe probability of live birth from an in vitro fertilization (IVF) cycle is modest. Many additional treatments (add-ons) are available which promise to improve the success of IVF. This review summarizes the current evidence for common IVF add-ons which are suggested to improve endometrial receptivity. Systematic reviews of randomized controlled trials and individual trials were included. Five add-ons were included: immune therapies, endometrial scratching, endometrial receptivity array, uterine artery vasodilation, and human chorionic gonadotropin instillation. The results suggest there is no robust evidence that these add-ons are effective or safe. Many IVF add-ons are costly, consuming precious resources which may be better spent on evidence-based treatments or further IVF. Large randomized controlled trials and appropriate safety assessment should be mandatory before the introduction of IVF add-ons into routine practice.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/fertnstert-
dc.relation.ispartofFertility and Sterility-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectIVF add-on-
dc.subjecttreatment add-on-
dc.subjectadjuvant-
dc.subjectIVF adjunct-
dc.titleIn vitro fertilization add-ons for the endometrium: it doesn’t add-up-
dc.typeArticle-
dc.identifier.emailNg, EHY: nghye@hku.hk-
dc.identifier.authorityNg, EHY=rp00426-
dc.description.naturepostprint-
dc.identifier.doi10.1016/j.fertnstert.2019.10.011-
dc.identifier.pmid31843098-
dc.identifier.scopuseid_2-s2.0-85076283570-
dc.identifier.hkuros314951-
dc.identifier.volume112-
dc.identifier.issue6-
dc.identifier.spage987-
dc.identifier.epage993-
dc.identifier.isiWOS:000502762700004-
dc.publisher.placeUnited States-
dc.identifier.issnl0015-0282-

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