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- Publisher Website: 10.1177/0962280220922258
- Scopus: eid_2-s2.0-85084862146
- PMID: 32394808
- WOS: WOS:000533974800001
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Article: Survival analysis with change-points in covariate effects
| Title | Survival analysis with change-points in covariate effects |
|---|---|
| Authors | |
| Keywords | Clinical trials change-points right-censored data likelihood ratio tests sequential analysis |
| Issue Date | 2020 |
| Publisher | Sage Publications Ltd. The Journal's web site is located at http://smm.sagepub.com |
| Citation | Statistical Methods in Medical Research, 2020, v. 29 n. 11, p. 3235-3248 How to Cite? |
| Abstract | We apply a maximal likelihood ratio test for the presence of multiple change-points in the covariate effects based on the Cox regression model. The covariate effect is assumed to change smoothly at one or more unknown change-points. The number of change-points is inferred by a sequential approach. Confidence intervals for the regression and changepoint parameters are constructed by a bootstrap method based on Bernstein polynomials conditionally on the number of change-points. The methods are assessed by simulations and are applied to two datasets. |
| Persistent Identifier | http://hdl.handle.net/10722/288160 |
| ISSN | 2023 Impact Factor: 1.6 2023 SCImago Journal Rankings: 1.235 |
| ISI Accession Number ID |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | LEE, CY | - |
| dc.contributor.author | Lam, KF | - |
| dc.date.accessioned | 2020-10-05T12:08:45Z | - |
| dc.date.available | 2020-10-05T12:08:45Z | - |
| dc.date.issued | 2020 | - |
| dc.identifier.citation | Statistical Methods in Medical Research, 2020, v. 29 n. 11, p. 3235-3248 | - |
| dc.identifier.issn | 0962-2802 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/288160 | - |
| dc.description.abstract | We apply a maximal likelihood ratio test for the presence of multiple change-points in the covariate effects based on the Cox regression model. The covariate effect is assumed to change smoothly at one or more unknown change-points. The number of change-points is inferred by a sequential approach. Confidence intervals for the regression and changepoint parameters are constructed by a bootstrap method based on Bernstein polynomials conditionally on the number of change-points. The methods are assessed by simulations and are applied to two datasets. | - |
| dc.language | eng | - |
| dc.publisher | Sage Publications Ltd. The Journal's web site is located at http://smm.sagepub.com | - |
| dc.relation.ispartof | Statistical Methods in Medical Research | - |
| dc.rights | Author(s), Contribution Title, Journal Title (Journal Volume Number and Issue Number) pp. xx-xx. Copyright © [year] (Copyright Holder). DOI: [DOI number]. | - |
| dc.subject | Clinical trials | - |
| dc.subject | change-points | - |
| dc.subject | right-censored data | - |
| dc.subject | likelihood ratio tests | - |
| dc.subject | sequential analysis | - |
| dc.title | Survival analysis with change-points in covariate effects | - |
| dc.type | Article | - |
| dc.identifier.email | Lam, KF: hrntlkf@hkucc.hku.hk | - |
| dc.identifier.authority | Lam, KF=rp00718 | - |
| dc.description.nature | link_to_subscribed_fulltext | - |
| dc.identifier.doi | 10.1177/0962280220922258 | - |
| dc.identifier.pmid | 32394808 | - |
| dc.identifier.scopus | eid_2-s2.0-85084862146 | - |
| dc.identifier.hkuros | 314785 | - |
| dc.identifier.volume | 29 | - |
| dc.identifier.issue | 11 | - |
| dc.identifier.spage | 3235 | - |
| dc.identifier.epage | 3248 | - |
| dc.identifier.eissn | 1477-0334 | - |
| dc.identifier.isi | WOS:000533974800001 | - |
| dc.publisher.place | United Kingdom | - |
| dc.identifier.issnl | 0962-2802 | - |