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Article: Effects of adjunctive probiotic L. reuteri lozenges on S/RSD outcomes at molar sites with deep pockets

TitleEffects of adjunctive probiotic L. reuteri lozenges on S/RSD outcomes at molar sites with deep pockets
Authors
KeywordsL. reuteri
molar
non‐surgical periodontal therapy
periodontitis
probiotics
Issue Date2020
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-051X
Citation
Journal of Clinical Periodontology, 2020, v. 47 n. 9, p. 1098-1107 How to Cite?
AbstractAim: To evaluate effects of probiotic Lactobacillus reuteri (L. reuteri) lozenges as an S/RSD adjunct on site‐level changes at molars with deep pockets. Materials and methods: 447 molar sites with pockets ≥ 5 mm from a previous randomized clinical trial of adjunctive L. reuteri lozenges for 28 days were analyzed. Multilevel mixed‐effect models (MLM) were constructed to analyze site‐level outcomes “change in CAL” and “pocket closure” (residual PPD < 5 mm) in placebo and probiotic groups at 90 and 180 days. Possible patient‐, tooth‐, and site‐level predictors were analyzed as fixed‐effects. Results: Estimated change in CAL in probiotic (90 day: 0.87 mm, 180 day: 0.68 mm) was greater than placebo treated molar sites (90 day: 0.73 mm, 180 day: 0.66 mm) and the relative risk (RR) of pocket closure in the probiotic group (90 day: 1.7, 180 day: 1.6) was higher as compared to placebo. Furcation involvement and BOP at site predicted significantly worse treatment outcomes. Conclusion: As compared to S/RSD with placebo, a 28‐day course of adjunctive probiotic L. reuteri lozenges improved CAL change at molar sites with ≥ 5 mm deep pockets and conferred a higher probability of shallow residual pocket depth. Presence of furcation‐involvement and bleeding on probing worsened treatment outcomes.
Persistent Identifierhttp://hdl.handle.net/10722/288009
ISSN
2023 Impact Factor: 5.8
2023 SCImago Journal Rankings: 2.249
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPelekos, G-
dc.contributor.authorAcharya, A-
dc.contributor.authorEiji, N-
dc.contributor.authorHong, G-
dc.contributor.authorLeung, WK-
dc.contributor.authorMcGrath, C-
dc.date.accessioned2020-10-05T12:06:31Z-
dc.date.available2020-10-05T12:06:31Z-
dc.date.issued2020-
dc.identifier.citationJournal of Clinical Periodontology, 2020, v. 47 n. 9, p. 1098-1107-
dc.identifier.issn0303-6979-
dc.identifier.urihttp://hdl.handle.net/10722/288009-
dc.description.abstractAim: To evaluate effects of probiotic Lactobacillus reuteri (L. reuteri) lozenges as an S/RSD adjunct on site‐level changes at molars with deep pockets. Materials and methods: 447 molar sites with pockets ≥ 5 mm from a previous randomized clinical trial of adjunctive L. reuteri lozenges for 28 days were analyzed. Multilevel mixed‐effect models (MLM) were constructed to analyze site‐level outcomes “change in CAL” and “pocket closure” (residual PPD < 5 mm) in placebo and probiotic groups at 90 and 180 days. Possible patient‐, tooth‐, and site‐level predictors were analyzed as fixed‐effects. Results: Estimated change in CAL in probiotic (90 day: 0.87 mm, 180 day: 0.68 mm) was greater than placebo treated molar sites (90 day: 0.73 mm, 180 day: 0.66 mm) and the relative risk (RR) of pocket closure in the probiotic group (90 day: 1.7, 180 day: 1.6) was higher as compared to placebo. Furcation involvement and BOP at site predicted significantly worse treatment outcomes. Conclusion: As compared to S/RSD with placebo, a 28‐day course of adjunctive probiotic L. reuteri lozenges improved CAL change at molar sites with ≥ 5 mm deep pockets and conferred a higher probability of shallow residual pocket depth. Presence of furcation‐involvement and bleeding on probing worsened treatment outcomes.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-051X-
dc.relation.ispartofJournal of Clinical Periodontology-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Postprint This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectL. reuteri-
dc.subjectmolar-
dc.subjectnon‐surgical periodontal therapy-
dc.subjectperiodontitis-
dc.subjectprobiotics-
dc.titleEffects of adjunctive probiotic L. reuteri lozenges on S/RSD outcomes at molar sites with deep pockets-
dc.typeArticle-
dc.identifier.emailPelekos, G: george74@hku.hk-
dc.identifier.emailAcharya, A: aneesha@hku.hk-
dc.identifier.emailLeung, WK: ewkleung@hkucc.hku.hk-
dc.identifier.emailMcGrath, C: mcgrathc@hkucc.hku.hk-
dc.identifier.authorityPelekos, G=rp01894-
dc.identifier.authorityLeung, WK=rp00019-
dc.identifier.authorityMcGrath, C=rp00037-
dc.description.naturelink_to_subscribed_fulltext-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/jcpe.13329-
dc.identifier.pmid32511775-
dc.identifier.scopuseid_2-s2.0-85087297020-
dc.identifier.hkuros314630-
dc.identifier.volume47-
dc.identifier.issue9-
dc.identifier.spage1098-
dc.identifier.epage1107-
dc.identifier.isiWOS:000543922500001-
dc.publisher.placeUnited States-
dc.identifier.issnl0303-6979-

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