File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Allergic Diseases and Immune-Mediated Food Disorders in Pediatric Acute-Onset Neuropsychiatric Syndrome

TitleAllergic Diseases and Immune-Mediated Food Disorders in Pediatric Acute-Onset Neuropsychiatric Syndrome
Authors
Keywordsallergies
celiac
elimination
food
immunologic
Issue Date2018
PublisherMary Ann Liebert, Inc. Publishers. The Journal's web site is located at https://home.liebertpub.com/publications/pediatric-allergy-immunology-and-pulmonology/48/
Citation
Pediatric Allergy, Immunology, and Pulmonology, 2018, v. 31 n. 3, p. 158-165 How to Cite?
AbstractBackground: The prevalence and impact of allergic and immune-mediated food disorders in pediatric acute-onset neuropsychiatric syndrome (PANS) are mostly unknown. Objective: We sought to explore the prevalence of atopic dermatitis (AD), asthma, allergic rhinitis (AR), IgE-mediated food allergies (FAs), and other immune-mediated food disorders requiring food avoidance in patients with PANS. In addition, to further understand the extent of food restriction in this population, we investigated the empiric use of dietary measures to improve PANS symptoms. Methods: Pediatric patients in a PANS Clinic and Research Program were given surveys regarding their caregiver burdens, allergic and food-related medical history, and whether food elimination resulted in perception of improvement of PANS symptoms. A review of health records was conducted to confirm that all responses in the survey were concordant with documentation of each patient's medical chart. Results: Sixty-nine (ages 4-20 years) of 80 subjects who fulfilled PANS criteria completed the surveys. Thirteen (18.8%) had AD, 11 (15.9%) asthma, 33 (47.8%) AR, 11 (15.9%) FA, 1 (1.4%) eosinophilic gastrointestinal disorders, 1 (1.4%) food protein-induced enterocolitis syndrome, 3 (4.3%) milk protein-induced proctocolitis syndrome, and 3 (4.3%) celiac disease. Thirty subjects (43.5%) avoided foods due to PANS; elimination of gluten and dairy was most common and was associated with perceived improvement of PANS symptoms (by parents). This perceived improvement was not confirmed with objective data. Conclusions: The prevalence of allergic and immune-mediated food disorders in PANS is similar to the general population as reported in the literature, with the exception of AR that appears to be more prevalent in our PANS cohort. More research will be required to establish whether diet or allergies influence PANS symptoms.
Persistent Identifierhttp://hdl.handle.net/10722/287966
ISSN
2023 Impact Factor: 1.1
2023 SCImago Journal Rankings: 0.342
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorS. Rosa, J-
dc.contributor.authorHernandez, JD-
dc.contributor.authorSherr, JA-
dc.contributor.authorSmith, BM-
dc.contributor.authorBrown, KD-
dc.contributor.authorFarhadian, B-
dc.contributor.authorMahony, T-
dc.contributor.authorMcGhee, SA-
dc.contributor.authorLewis, DB-
dc.contributor.authorThienemann, M-
dc.contributor.authorFrankovich, JD-
dc.date.accessioned2020-10-05T12:05:52Z-
dc.date.available2020-10-05T12:05:52Z-
dc.date.issued2018-
dc.identifier.citationPediatric Allergy, Immunology, and Pulmonology, 2018, v. 31 n. 3, p. 158-165-
dc.identifier.issn2151-321X-
dc.identifier.urihttp://hdl.handle.net/10722/287966-
dc.description.abstractBackground: The prevalence and impact of allergic and immune-mediated food disorders in pediatric acute-onset neuropsychiatric syndrome (PANS) are mostly unknown. Objective: We sought to explore the prevalence of atopic dermatitis (AD), asthma, allergic rhinitis (AR), IgE-mediated food allergies (FAs), and other immune-mediated food disorders requiring food avoidance in patients with PANS. In addition, to further understand the extent of food restriction in this population, we investigated the empiric use of dietary measures to improve PANS symptoms. Methods: Pediatric patients in a PANS Clinic and Research Program were given surveys regarding their caregiver burdens, allergic and food-related medical history, and whether food elimination resulted in perception of improvement of PANS symptoms. A review of health records was conducted to confirm that all responses in the survey were concordant with documentation of each patient's medical chart. Results: Sixty-nine (ages 4-20 years) of 80 subjects who fulfilled PANS criteria completed the surveys. Thirteen (18.8%) had AD, 11 (15.9%) asthma, 33 (47.8%) AR, 11 (15.9%) FA, 1 (1.4%) eosinophilic gastrointestinal disorders, 1 (1.4%) food protein-induced enterocolitis syndrome, 3 (4.3%) milk protein-induced proctocolitis syndrome, and 3 (4.3%) celiac disease. Thirty subjects (43.5%) avoided foods due to PANS; elimination of gluten and dairy was most common and was associated with perceived improvement of PANS symptoms (by parents). This perceived improvement was not confirmed with objective data. Conclusions: The prevalence of allergic and immune-mediated food disorders in PANS is similar to the general population as reported in the literature, with the exception of AR that appears to be more prevalent in our PANS cohort. More research will be required to establish whether diet or allergies influence PANS symptoms.-
dc.languageeng-
dc.publisherMary Ann Liebert, Inc. Publishers. The Journal's web site is located at https://home.liebertpub.com/publications/pediatric-allergy-immunology-and-pulmonology/48/-
dc.relation.ispartofPediatric Allergy, Immunology, and Pulmonology-
dc.rightsPediatric Allergy, Immunology, and Pulmonology. Copyright © Mary Ann Liebert, Inc. Publishers.-
dc.rightsFinal publication is available from Mary Ann Liebert, Inc., publishers http://dx.doi.org/[insert DOI]-
dc.subjectallergies-
dc.subjectceliac-
dc.subjectelimination-
dc.subjectfood-
dc.subjectimmunologic-
dc.titleAllergic Diseases and Immune-Mediated Food Disorders in Pediatric Acute-Onset Neuropsychiatric Syndrome-
dc.typeArticle-
dc.identifier.emailS. Rosa, J: jsrduque@hku.hk-
dc.identifier.authorityS. Rosa, J=rp02340-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1089/ped.2018.0888-
dc.identifier.pmid30283713-
dc.identifier.pmcidPMC6154445-
dc.identifier.scopuseid_2-s2.0-85053735860-
dc.identifier.hkuros315818-
dc.identifier.volume31-
dc.identifier.issue3-
dc.identifier.spage158-
dc.identifier.epage165-
dc.identifier.isiWOS:000445067100006-
dc.publisher.placeUnited States-
dc.identifier.issnl2151-321X-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats