File Download
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.7554/eLife.58567
- Scopus: eid_2-s2.0-85090077149
- PMID: 32838838
- WOS: WOS:000563793400001
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Investigating pleiotropic effects of statins on ischemic heart disease in the UK Biobank using Mendelian randomisation
Title | Investigating pleiotropic effects of statins on ischemic heart disease in the UK Biobank using Mendelian randomisation |
---|---|
Authors | |
Keywords | Mendelian Randomization Analysis Instrumental Variable Estimate Causal Effect |
Issue Date | 2020 |
Publisher | eLife Sciences Publications Ltd. The Journal's web site is located at http://elifesciences.org/ |
Citation | eLife, 2020, v. 9, p. article no. e58567 How to Cite? |
Abstract | We examined whether specifically statins, of the major lipid modifiers (statins, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors and ezetimibe) have pleiotropic effects on ischemic heart disease (IHD) via testosterone in men or women. As a validation, we similarly assessed whether a drug that unexpectedly likely increases IHD also operates via testosterone. Using previously published genetic instruments we conducted a sex-specific univariable and multivariable Mendelian randomization study in the UK Biobank, including 179918 men with 25410 IHD cases and 212080 women with 12511 IHD cases. Of these three lipid modifiers, only genetically mimicking the effects of statins in men affected testosterone, which partly mediated effects on IHD. Correspondingly, genetically mimicking effects of anakinra on testosterone and IHD presented a reverse pattern to that for statins. These insights may facilitate the development of new interventions for cardiovascular diseases as well as highlighting the importance of sex-specific explanations, investigations, prevention and treatment. |
Persistent Identifier | http://hdl.handle.net/10722/287940 |
ISSN | 2023 Impact Factor: 6.4 2023 SCImago Journal Rankings: 3.932 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Schooling, CM | - |
dc.contributor.author | Zhao, JV | - |
dc.contributor.author | Au Yeung, SL | - |
dc.contributor.author | Leung, GM | - |
dc.date.accessioned | 2020-10-05T12:05:28Z | - |
dc.date.available | 2020-10-05T12:05:28Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | eLife, 2020, v. 9, p. article no. e58567 | - |
dc.identifier.issn | 2050-084X | - |
dc.identifier.uri | http://hdl.handle.net/10722/287940 | - |
dc.description.abstract | We examined whether specifically statins, of the major lipid modifiers (statins, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors and ezetimibe) have pleiotropic effects on ischemic heart disease (IHD) via testosterone in men or women. As a validation, we similarly assessed whether a drug that unexpectedly likely increases IHD also operates via testosterone. Using previously published genetic instruments we conducted a sex-specific univariable and multivariable Mendelian randomization study in the UK Biobank, including 179918 men with 25410 IHD cases and 212080 women with 12511 IHD cases. Of these three lipid modifiers, only genetically mimicking the effects of statins in men affected testosterone, which partly mediated effects on IHD. Correspondingly, genetically mimicking effects of anakinra on testosterone and IHD presented a reverse pattern to that for statins. These insights may facilitate the development of new interventions for cardiovascular diseases as well as highlighting the importance of sex-specific explanations, investigations, prevention and treatment. | - |
dc.language | eng | - |
dc.publisher | eLife Sciences Publications Ltd. The Journal's web site is located at http://elifesciences.org/ | - |
dc.relation.ispartof | eLife | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Mendelian Randomization Analysis | - |
dc.subject | Instrumental Variable Estimate | - |
dc.subject | Causal Effect | - |
dc.title | Investigating pleiotropic effects of statins on ischemic heart disease in the UK Biobank using Mendelian randomisation | - |
dc.type | Article | - |
dc.identifier.email | Schooling, CM: cms1@hkucc.hku.hk | - |
dc.identifier.email | Zhao, JV: janezhao@hku.hk | - |
dc.identifier.email | Au Yeung, SL: ayslryan@hku.hk | - |
dc.identifier.email | Leung, GM: gmleung@hku.hk | - |
dc.identifier.authority | Schooling, CM=rp00504 | - |
dc.identifier.authority | Zhao, JV=rp02336 | - |
dc.identifier.authority | Au Yeung, SL=rp02224 | - |
dc.identifier.authority | Leung, GM=rp00460 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.7554/eLife.58567 | - |
dc.identifier.pmid | 32838838 | - |
dc.identifier.pmcid | PMC7449694 | - |
dc.identifier.scopus | eid_2-s2.0-85090077149 | - |
dc.identifier.hkuros | 315524 | - |
dc.identifier.volume | 9 | - |
dc.identifier.spage | article no. e58567 | - |
dc.identifier.epage | article no. e58567 | - |
dc.identifier.isi | WOS:000563793400001 | - |
dc.publisher.place | Cambridge, UK | - |
dc.identifier.issnl | 2050-084X | - |