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Conference Paper: A Multi-Centre Clinical Trial of CNS Germ Cell Tumours in Hong Kong

TitleA Multi-Centre Clinical Trial of CNS Germ Cell Tumours in Hong Kong
Authors
Keywordsmagnetic resonance imaging
radiation therapy
basal ganglia
biopsy
chemotherapy regimen
Issue Date2018
PublisherOxford University Press. The Journal's web site is located at http://neuro-oncology.dukejournals.org
Citation
The 18th International Symposium on Pediatric Neuro-Oncology (ISPNO 2018) , Denver, Colorado, USA, 30 June – 3 July 2018. Abstracts in Neuro-Oncology, 2018, v. 20 n. Suppl. 2, p. i86, article no. GERM-16 How to Cite?
AbstractMETHOD: This clinical trial started from January 2008 and ended in June 2014. Patients who were suspected to have germinoma received a biopsy, followed by chemotherapy with carboplatin (600 mg per m2 on day 1) and etoposide (150 mg per m2 per day, day 1 to 3), alternating with ifosfamide (1.8 mg per m2 per day and etoposide 150 mg per m2 per day, day 1 to 5). They were assessed with MRI every 2 cycles. A total of 4 cycles of chemotherapy were given, followed by radiotherapy. The dose and volume of radiotherapy depend on the response and site of involvement. Patients with non-germinomatous germ cell tumours received operation to remove the tumour (if possible), chemotherapy as above for 6 cycles, reassessed by MRI once in two cycles, and cranio-spinal radiotherapy. The patients may need a second look operation if necessary. RESULTS: The data were reviewed on 31 May 2017. There were 45 patients, male to female ratio: 2.8:1, median age: 12.5 years of age (0.4 to 18.7). The pathology were germinoma (n=24) and non-germinomatous germ cell tumours (n=21). The locations of the tumours were suprasellar/sellar(n=13), pineal gland (n=20), suprasellar & pineal gland (n=7) and basal ganglia (n=4) and left frontal lobe (n=1). Five patients had metastatic diseases at presentation. Two patient had relapses. The median follow-up time was 6.75 years (2.43 to 9.54). PFS and OS at 5 years were 95.5% and 100% respectively. CONCLUSION: With a multidisciplinary approach, a satisfactory outcome is achieved.
Persistent Identifierhttp://hdl.handle.net/10722/287804
ISSN
2020 Impact Factor: 12.3
2015 SCImago Journal Rankings: 3.196

 

DC FieldValueLanguage
dc.contributor.authorShing, MMK-
dc.contributor.authorChan, GCF-
dc.contributor.authorLuk, CW-
dc.contributor.authorKu, DTL-
dc.contributor.authorLiu, APY-
dc.contributor.authorLing, SC-
dc.date.accessioned2020-10-05T12:03:32Z-
dc.date.available2020-10-05T12:03:32Z-
dc.date.issued2018-
dc.identifier.citationThe 18th International Symposium on Pediatric Neuro-Oncology (ISPNO 2018) , Denver, Colorado, USA, 30 June – 3 July 2018. Abstracts in Neuro-Oncology, 2018, v. 20 n. Suppl. 2, p. i86, article no. GERM-16-
dc.identifier.issn1522-8517-
dc.identifier.urihttp://hdl.handle.net/10722/287804-
dc.description.abstractMETHOD: This clinical trial started from January 2008 and ended in June 2014. Patients who were suspected to have germinoma received a biopsy, followed by chemotherapy with carboplatin (600 mg per m2 on day 1) and etoposide (150 mg per m2 per day, day 1 to 3), alternating with ifosfamide (1.8 mg per m2 per day and etoposide 150 mg per m2 per day, day 1 to 5). They were assessed with MRI every 2 cycles. A total of 4 cycles of chemotherapy were given, followed by radiotherapy. The dose and volume of radiotherapy depend on the response and site of involvement. Patients with non-germinomatous germ cell tumours received operation to remove the tumour (if possible), chemotherapy as above for 6 cycles, reassessed by MRI once in two cycles, and cranio-spinal radiotherapy. The patients may need a second look operation if necessary. RESULTS: The data were reviewed on 31 May 2017. There were 45 patients, male to female ratio: 2.8:1, median age: 12.5 years of age (0.4 to 18.7). The pathology were germinoma (n=24) and non-germinomatous germ cell tumours (n=21). The locations of the tumours were suprasellar/sellar(n=13), pineal gland (n=20), suprasellar & pineal gland (n=7) and basal ganglia (n=4) and left frontal lobe (n=1). Five patients had metastatic diseases at presentation. Two patient had relapses. The median follow-up time was 6.75 years (2.43 to 9.54). PFS and OS at 5 years were 95.5% and 100% respectively. CONCLUSION: With a multidisciplinary approach, a satisfactory outcome is achieved.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://neuro-oncology.dukejournals.org-
dc.relation.ispartofNeuro-Oncology-
dc.relation.ispartofThe 18th International Symposium on Pediatric Neuro-Oncology (ISPNO 2018)-
dc.subjectmagnetic resonance imaging-
dc.subjectradiation therapy-
dc.subjectbasal ganglia-
dc.subjectbiopsy-
dc.subjectchemotherapy regimen-
dc.titleA Multi-Centre Clinical Trial of CNS Germ Cell Tumours in Hong Kong-
dc.typeConference_Paper-
dc.identifier.emailChan, GCF: gcfchan@hku.hk-
dc.identifier.emailLiu, APY: apyliu@hku.hk-
dc.identifier.authorityChan, GCF=rp00431-
dc.identifier.authorityLiu, APY=rp01357-
dc.description.natureabstract-
dc.identifier.doi10.1093/neuonc/noy059.263-
dc.identifier.hkuros315022-
dc.identifier.volume20-
dc.identifier.issueSuppl. 2-
dc.identifier.spagei86-
dc.identifier.epagei86-
dc.publisher.placeUnited States-
dc.identifier.issnl1522-8517-

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